Clinical Problems Associated With Aging Process
Clinical Problems Associated With Aging Process
Clinical Problems Associated With Aging Process
Currently, the CDC recommends routine vaccination against influenza, pneumococcus and
shingles as they are prevalent in this age group.
Treatment of Common Diseases -
Hypertension
Hypertension –Blood pressure targets remain controversial. protective benefits versus the risk of
treatment-related adverse events must be considered in individual patients based on their
comorbidities.
For older patients with minimal comorbidity, no postural hypotension, and low risk of falls and volume
depletion, the benefit/risk ratio favors lower targets for systolic blood pressure (<130 mmHg measured
by a hand sphygmomanometer).
However, for those with diabetes, heart failure, history of stroke, postural hypotension, careful
treatment of blood pressure with higher systolic targets (< 150 mmHg) is probably a safer approach.
Treatment of Common Diseases –
Diabetes
The prevalence of diabetes in the older adult population is now over 25% and expected to increase
due to adverse lifestyle changes and an increased incidence of obesity.
Older diabetic patients are at significant risk of hypoglycemia because of potential medication
errors, progressive decline in renal function, and inconsistent oral intake among other reasons.
Hypoglycemic episodes are associated with progressive cognitive decline in older adults, especially
those with existing cognitive impairment.
On the other hand, uncontrolled diabetes is associated with an increased risk of all-cause
dementia.
The goals of treating diabetes in the geriatric population should be tailored to the patient’s
functional and medical status, social support, personal goals, perception of risk, and life
expectancy.
Osteoarthritis
Osteoarthritis - The approach to the management of symptomatic OA in the geriatric population
differs from the approach in younger patients because of the risks of toxicity of nonsteroidal
anti-inflammatory drugs (NSAIDs) in older patients. Nonpharmacologic interventions should be
the first line of treatment.
Many older patients respond well to a variety of non-pharmacologic interventions, including
stretching, strengthening, timely and appropriate use of heat and ice, massage, swimming and
whirlpool therapy, bracing, acupuncture, and therapeutic electrical stimulation.
Surgical interventions, including replacement of major joints, have improved over the last
several years, and even older patients with multi-morbidity may experience improved function
and quality of life.
Cancer
More than half of new cases of cancer and mortality associated with it occur after the age of 65.
Older adults generally experience decreases in functional status after receiving chemotherapy.
Most of this negative effect appears to be related to comorbidity and baseline functional status,
rather than due to age alone.
Lack of social support has been associated with poor outcomes after radiation and
chemotherapy, especially in older women.
Other important issues in cancer treatment planning include availability of transportation for
treatments, economic and insurance status, the patient’s ability to follow treatment plans, and
family and social support available during therapy, when adverse effects and functional decline
may occur.
Geriatric Syndromes
and Conditions
C O G N I T I V E I M PA I R M E N T
U R I N A RY I N C O N T I N E N C E
N E G L E C T A N D A B U S E O F T H E E L D E R LY
Cognitive Impairment – Delirium and
Dementia
Delirium occurs in up to 40% of hospitalized older patients, and is associated with increased morbidity, need for
institutional care, and mortality in this population. While most episodes of delirium clear within a few days if the
underlying cause(s) are identified and treated, delirium may persist for weeks, and in a few cases for months, after an
acute hospitalization. No non-pharmacological or pharmacological intervention has been shown to prevent progression
to dementia.
The prevalence of dementia increases with age; by age 85 between 30 and 40% have a dementia syndrome.
Alzheimer’s disease and vascular dementia, which often occur together based on pathologic studies, account for most
dementias in older people.
Dementia with Lewy bodies accounts for up to 25% of dementia, and is characterized by Parkinsonian features early in
the disease (as opposed to dementia in Parkinson’s disease, which generally occurs years after the onset of
Parkinson’s), personality changes, alterations in alertness and attention, and visual hallucinations that can cause
paranoia.
Most dementia syndromes are slowly progressive over several years; however, dementia is a terminal illness among
patients who do not succumb to other comorbidities, and results in devastating loss of cognition and function in the
later stages.
Principle of Dementia
Management
There are four basic approaches to the
pharmacological treatment of dementia:
(1) avoid drugs that can worsen cognitive function,
mainly those with strong anticholinergic activity;
(2) agents that enhance cognition and function;
(3) drug treatment of coexisting depression, which
is common throughout the course of dementia; and
(4) pharmacological treatment of complications
such as paranoia, delusions, psychosis, and
behavioral symptoms such as agitation (verbal and
physical).
Urinary Incontinence
Urinary incontinence is curable or controllable in many geriatric patients, especially those who have
adequate mobility and mental functioning.
Even when it is not curable, incontinence can be managed in a manner that keeps people
comfortable, makes life easier for caregivers, and minimizes the costs of caring for the condition and
its complications.
Approximately one in three women and 15 to 20% of men aged >65 years have some degree of
urinary incontinence.
It can be followed by:
Isolation
Depression
Skin lesions
Nocturia
Elder Abuse and Neglect
Elder abuse is physical or psychologic mistreatment, neglect, or financial exploitation of older adults.
Common types of elder abuse include physical abuse, psychologic abuse, neglect, and financial abuse. Each type may
be intentional or unintentional. Poly-victimization (co-occurrence of multiple forms of abuse) is common. The
perpetrators are often adult children but may be other family members or paid or informal caregivers.
Physical abuse is use of force resulting in physical or psychologic injury or discomfort. It includes striking, shoving,
shaking, beating, restraining, forceful feeding, and unwarranted administration of drugs.
Psychologic abuse is use of words, acts, or other means to cause emotional stress or anguish. It includes issuing
threats (eg, of institutionalization), insults, and harsh commands, as well as remaining silent and ignoring the person.
It also includes infantilization (a patronizing form of ageism in which the perpetrator treats the older person as a
child), which encourages the older person to become dependent on the perpetrator.
Neglect is the failure or refusal to provide food, medicine, personal care, or other necessities; it also includes
abandonment. Neglect that results in physical or psychologic harm is considered abuse.
Financial abuse is exploitation of or inattention to a person’s possessions or funds. It includes swindling, pressuring a
person to distribute assets, and managing a person’s money irresponsibly.
Symptoms and signs of elder abuse may
erroneously be attributed to a chronic disorder.
However, the following clinical situations are
particularly suggestive of abuse: