Therapeutic Drug Monitoring (TDM) : Buddhini Nayanathara Bpharm (Uor)
Therapeutic Drug Monitoring (TDM) : Buddhini Nayanathara Bpharm (Uor)
Therapeutic Drug Monitoring (TDM) : Buddhini Nayanathara Bpharm (Uor)
(TDM)
Buddhini Nayanathara
BPharm(UOR)
Objectives
• Then we can identify whether that concentrations are within the safe
area or not (according to the therapeutic window of particular drug)
• Then we can adjust the dose according to that (on safe area)
THERAPEUTIC RANGE
MEC
TIME
• Antiepileptics
Ex. Phenytoin, Valporic acid, etc.
• Antiarrythmics
Ex. Digitalis, Lignocaine, etc.
• Antibiotics
Ex. Gentamycin, Amikacin, Tobramycin
• Antineoplastics
Ex. Methotrexate
• Antimanics
Ex. Lithium
• Bronchodilators
Ex. Theophylline
• Immunosuppressives
Ex. Cyclosporine
Indications for TDM
1. Drugs with a low therapeutic window:- will allow dose alterations to produce
optimal therapeutic effect or to avoid toxic effects. Ex: Lithium, phenytoin, and
digoxin
For that,
5mg/L No bronchodilation