Plasma Expanders
Plasma Expanders
Plasma Expanders
Disadvantages:
• Costly as compared to dextran
HUMAN ALBUMIN
INTERACTION:
• Binds with penicillin and insulin so cannot be used
with these drugs.
HYDROXYETHYLSTARCH
• Starch is destroyed by amylase but hydroxyethyl derivatives
are resistant to enzyme amylase.
• Hydroxyethylstarch is a complex mixture and formed by
ethoxylation of amylopectin.
• Its advantages over dextran are that its duration is longer,
does not cause allergic reaction and does not interfere with
coagulation and no chances of renal failure.
• 6 % solution is used
• It adverse effects are vomiting, fever, itching and
anaphylactoid reaction manifested as urticaria,
bronchospasm etc.
• It accelerates sedimentation of red blood cells and thus,
additionally may used for isolation of granulocytes.
Important questions
Name few plasma expanders