Lecture 42 - IDA & Iron Overload
Lecture 42 - IDA & Iron Overload
Lecture 42 - IDA & Iron Overload
Non-heme iron:
Vegetables
Fe+3
Iron absorption:
duodenum,
jejunum
The
distribution
of iron in
tissue
The Iron Cycle
Receptor-mediated transferrin endocytosis
Transferrin Receptor
Absorption of Iron
– Duodenum, jejunum
Absorption of Iron
• Blood smear
• Iron studies for iron deficiency
• Bone marrow iron stores
Iron deficiency anemia is a
microcytic hypochromic anemia
• Iron deficiency
• Sideroblastic anemia
• Thalassemia trait
• Lead poisoning
• Anemia of chronic disease
Management of IDA
• Treat underlying cause
• Replacement therapy
ferrous sulfate or gluconate
IDA
Normal
Hemosiderosis
Hemochromatosis
• is a genetic disease in which
the body accumulates excess
amounts of iron
• Serious and sometimes fatal
health problems may result
from the excess iron that
accumulates in the body
• arthritis, cirrhosis of the
liver, diabetes, heart failure,
and liver cancer
F e r r it in
R educed N o rm a l In c re a s e d
I r o n d e f ic ie n c y H B e le c t r o p h o r e s is A n e m ia o f C h r o n ic D is e a s e B o n e m a rro w
R in g e d s id e r o b la s ts
Hypochromia
Microcytic