CEREBELLUM

CEREBELLUM
DR MINU LIZ ABRAHAM

NEURAL CIRCUITS AND NEURONAL ACTIVITY IN
CEREBELLUM
 Deep cerebellar nuclei receive excitatory inputs via

Climbing fibers, Mossy fibers
 Deep cerebellar nuclei sends excitatory impulses to

Brainstem and thalamus .
 However Purkinje cells output is inhibitory to Deep

cerebellar nuclei
 Neuronal activity in cerebellar cortex plays a important role

in modulating excitatory signals
A. Deep cerebellar –Thalamus – Cerebral cortex – Spinal

cord
NEURONAL ACTIVITY OF INTRINSIC CEREBELLAR CIRCUIT
 Excitatory input from climbing fibers or mossy fibers sets up following activity
in the cerebellar circuit
A. FEEDFORWARD INHIBITION OF PURKINJE CELLS
B. FEEDFORWARD INHIBITION OF GRANULE CELLS
C. FEEDBACK INHIBITION OF GRANULE CELLS

MOSSY FIBRES
FEEDFORWARD STIMULATE
GRANULE CELLS
STIMULATE
INHIBITION OF STIMULATE PURKINJE CELL ( This excitation short lasting )
MOSSY FIBERS GRANULE CELLS
PURKINJE CELLS STIMULATE

STIMULATE
GRANULE CELL ALSO EXCITES BASKET
CELLS
PURKINJE CELLS BASKET CELLS

BASKET CELLS INHIBIT PURKINJE CELL
INHIBIT
• Basket cells and Purkinje cell excited by same
excitatory input- FEED FORWARD
MOSSY FIBRES
STIMULATE
FEEDFORWARD INHIBITION OF GRANULEGRANULE CELLS ( This excitation short
CELLS
lasting )
STIMULATE
MOSSY FIBERS GRANULE CELLS

MOSSY FIBRES also EXCITES GOLGI
CELLS
STIMULATE
INHIBIT
GOLGI CELLS GOLGI CELLS INHIBIT GRANULE CELL
• Since Granule cell and golgi cell are excited by

same excitatory input ( mossy fibres ) , this
arrangement is called feedforward inhibition
GRANULE CELL AXONS - PARALLEL FIBRES
FEEDBACK INHIBITION OF GRANULE
CELLS
STIMULATE
GOLGI CELL
GRANULE CELLS INHIBIT
GRANULE CELLS
STIMULATE
INHIBIT
• The excitation of granule cell is
GOLGI CELLS
extinguished by negative feedback ,
this arrangement is called feedback
inhibition of granule cells
CONNECTIONS OF
CEREBELLUM
 Cerebellum receives afferents and

sends efferents through 3 cerebellar
peduncles
I. Inferior cerebellar peduncle
II. Middle cerebellar peduncle
III. Superior cerebellar peduncle

AFFERENT FIBRES EFFERENT FIBERS
INFERIOR POSTERIOR SPINOCEREBELLAR CEREBELLOVESTIBULAR

TRACT TRACT
CEREBELLAR
PEDUNCLE RETICULOCEREBELLAR TRACT CEREBELLORETICULAR
TRACT
OLIVOCEREBELLAR TRACT
CEREBELLO- OLIVARY
VESTIBULOCEREBELLAR TRACT TRACT
CUNEOCEREBELLAR TRACT
AFFERENT FIBRES EFFERENT FIBERS
MIDDLE CEREBELLAR CORTICO PONTINE – COMMISSURAL

PEDUNCLE CEREBELLAR FIBERS FIBERS
SUPERIOR CEREBELLAR ANTERIOR DENTATORUBRAL

PEDUNCLE SPINOCEREBELLAR TRACT FIBRE
RUBROCEREBELLAR TRACT DENTATO RUBRO

THALAMOCORTICAL
TRACT
TECTOCEREBELLAR TRACT
CEREBELLO
RETICULAR TRACT
AFFERENT CONNECTIONS
I. FROM CEREBRAL CORTEX
 Cortico – ponto - cerebellar tract : Arises in Motor cortex and ends in pontine nuclei.
From pontine nuclei the pontocerebellar fibers cross to opposite side through middle
cerebellar peduncle. This tract conveys information to spinocerebellum from cerebral
cortex.
II. FROM SPINAL CORD
 Ventral spinocerebellar tract : Conveys Proprioceptive impulses from different parts of

body of opposite side
 Dorsal spinocerebellar tract : Conveys Proprioceptive impulses from different parts of

III. FROM CUNEATE NUCLEUS
 Cuneo-cerebellar tract : Conveys Proprioceptive impulses from head , neck and upper limb
IV. FROM VESTIBULAR APPARATUS

 Vestibulocerebellar fibers :Information regarding position and movement of head
V. FROM RED NUCLEUS AND TECTUM
 Rubrocerebellar and Tectocerebellar tracts : Carries visual impulses from superior colliculi and
auditory impulses from inferior colliculi
VI. FROM INFERIOR OLIVARY NUCLEI
 Olivocerebellar tract : Arises from olivary nucleus and enters the cerebellum via inferior cerebellar
peduncle to innervate all parts of cerebellar cortex and deep cerebellar nuclei via climbing fibers.
 Conveys proprioceptive impulses from different parts of body

[ CEREBELLAR EFFERENT FIBERS ]
 Purkinje cell axons pass to deep cerebellar nuclei
 Influence on these nuclei – INHIBITORY [ Release of GABA ]

NUCLEUS AFFERENT FIBRES FROM EFFERENT FIBERS TO
DENTATE NEOCEREBELLUM I. RED NUCEUS

II. VL NUCLEUS OF THALAMUS
These fibres finally get projected to motor

cortex
( Dentato- Rubro- thalamocortical fibres )
FASTIGIAL VESTIBULOCEREBELLUM I. VESTIBULAR NUCLEUS

( Fastigial vestibular pathway )
II. RETICULAR FORMATION
( Fastigial reticular pathway )

NUCLEUS AFFERENT FIBRES EFFERENT FIBERS TO
FROM
EMBOLIFORM SPINOCEREBELLUM RED NUCLEUS ( Emboliform rubral pathway )
GLOBOSUS SPINOCEREBELLUM RED NUCLEUS ( Globosus rubral pathway )

RETICULAR FORMATION

CEREBELLUM - Class 2

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DR MINU LIZ ABRAHAM

 Deep cerebellar nuclei receive excitatory inputs via

 Deep cerebellar nuclei sends excitatory impulses to

 However Purkinje cells output is inhibitory to Deep

 Neuronal activity in cerebellar cortex plays a important role

A. Deep cerebellar –Thalamus – Cerebral cortex – Spinal

A. FEEDFORWARD INHIBITION OF PURKINJE CELLS

B. FEEDFORWARD INHIBITION OF GRANULE CELLS

C. FEEDBACK INHIBITION OF GRANULE CELLS

PURKINJE CELLS STIMULATE

PURKINJE CELLS BASKET CELLS

MOSSY FIBERS GRANULE CELLS

GOLGI CELLS GOLGI CELLS INHIBIT GRANULE CELL

• Since Granule cell and golgi cell are excited by

GRANULE CELLS INHIBIT

 Cerebellum receives afferents and

I. Inferior cerebellar peduncle

II. Middle cerebellar peduncle

III. Superior cerebellar peduncle

INFERIOR POSTERIOR SPINOCEREBELLAR CEREBELLOVESTIBULAR

MIDDLE CEREBELLAR CORTICO PONTINE – COMMISSURAL

SUPERIOR CEREBELLAR ANTERIOR DENTATORUBRAL

RUBROCEREBELLAR TRACT DENTATO RUBRO

II. FROM SPINAL CORD

 Ventral spinocerebellar tract : Conveys Proprioceptive impulses from different parts of

 Dorsal spinocerebellar tract : Conveys Proprioceptive impulses from different parts of

IV. FROM VESTIBULAR APPARATUS

V. FROM RED NUCLEUS AND TECTUM

VI. FROM INFERIOR OLIVARY NUCLEI

 Conveys proprioceptive impulses from different parts of body

 Purkinje cell axons pass to deep cerebellar nuclei

 Influence on these nuclei – INHIBITORY [ Release of GABA ]

DENTATE NEOCEREBELLUM I. RED NUCEUS

These fibres finally get projected to motor

FASTIGIAL VESTIBULOCEREBELLUM I. VESTIBULAR NUCLEUS

II. RETICULAR FORMATION

( Fastigial reticular pathway )

EMBOLIFORM SPINOCEREBELLUM RED NUCLEUS ( Emboliform rubral pathway )

GLOBOSUS SPINOCEREBELLUM RED NUCLEUS ( Globosus rubral pathway )

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