6-Schizophrenia Lecture 2
6-Schizophrenia Lecture 2
6-Schizophrenia Lecture 2
FAHAD ALOSAIMI
MBBS, SSC-PSYCH
PSYCHOSOMATIC MEDICINE CONSULTANT
ASSISTANT PROFESSOR
KING KHALID UNIVERSITY HOSPITAL
KING SAUD UNIVERSITY, RIYADH
Schizophrenia (Background)
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Impression?!
Can schizophrenic patient win Nobel prize?
Etiology
Clinical features & diagnosis.
Differential diagnoses
Course & Prognosis
Treatment (Pharmacological)
Treatment (Psychological )
Case of Mr.J
Mr.J is a 25-year-old male with the diagnosis of schizophrenia.
He was a healthy child, but his parents report that he was a
bedwetter and seemed slower to develop than his brothers and
sisters.
A maternal uncle has also been diagnosed with schizophrenia.
Mr.J had 2 brief hospitalizations in his late teens that were
precipitated by anger at his boss, depression, and voices in his
head. He has believed that CIA is following him & control his
thoughts as well.
He found the hospital stays unhelpful. He was treated with
haloperidol which gave him dystonic symptoms; he was then
treated with olanzapine and gained 10 Kg and
developed diabetes mellitus.
Cont. Case of Mr.J
1- Stress-Diathesis Model:
Integrates biological, psychosocial and
environmental factors in the etiology of
schizophrenia.
Symptoms of schizophrenia develop when a person
has a specific vulnerability that is acted on by a
stressful influence.
2- Neurobiology
a- Dopamine Hypothesis;
Too much dopaminergic activity ( whether it is ↑ release of
dopamine, ↑ dopamine receptors, hypersensitivity of
dopamine receptors to dopamine, or combinations is not
known ).
b- Other Neurotransmitters;
Serotonin, Norepinephrine, GABA, Glutamate &
Neuropeptides
c- Neuropathology;
PLOS Medicine
Diagnosis
Paranoid type
Disorganized type
Catatonic type
Undifferentiated type
Residual type
Clinical Features
Etiology
Clinical features & diagnosis.
Differential diagnoses
Course & Prognosis
Treatment (Pharmacological)
Treatment (Psychological )