The Gupta Empire flourished in India from 320 to 550 CE. Key rulers included Chandragupta I, Samudragupta, and Chandragupta II, who expanded the empire and engaged in profitable trade. The empire was characterized by a relatively free society with advances in mathematics, science, arts, and literature. However, the empire declined due to invasions of the Huns, breaking India into separate kingdoms until the arrival of Muslims.
The procedure of hybridoma technology involves extracting lymphocytes from an immunized animal's spleen, mixing them with myeloma cells that do not produce their own antibodies, and culturing the hybrid cells in a selective HAT medium. This allows the hybrid cells that produce the desired antibodies to survive indefinitely for isolation and culture, enabling a continuous production of monoclonal antibodies from the cloned hybridoma cells.
Impaired mitochondrial protein synthesisAsh Hassan
This document summarizes key aspects of mitochondrial oxidative phosphorylation (OXPHOS). It notes that OXPHOS deficiencies can cause metabolic disorders and affect any organ at any age. The mitochondrial respiratory chain contains over 100 proteins, 13 of which are encoded by mitochondrial DNA while others come from nuclear DNA. Mitochondrial DNA is a 16,569 base pair circular molecule that replicates, transcribes, and translates independently. However, mitochondrial protein synthesis resembles prokaryotes and differs from the universal genetic code and mammalian systems. Defects in mitochondrial or nuclear genes involved in OXPHOS can cause related genetic diseases.
1. The production of monoclonal antibodies involves immunizing an animal like mice with an antigen, fusing their spleen cells that produce antibodies with myeloma tumor cells, and selecting the resulting hybridoma cells that continuously produce the desired antibodies.
2. The fused hybridoma cells are selected using HAT medium, which allows their growth while killing off unfused spleen and myeloma cells.
3. Individual hybridoma cells are further isolated by limiting dilution to produce monoclonal antibody-secreting clones from which a specific monoclonal antibody can be produced at large scale for commercial purposes.
HUMAN DISEASES WITH IMPAIRED MITOCHONDRIAL PROTEIN SYNTHESISAsh Hassan
This document summarizes human diseases related to impaired mitochondrial protein synthesis. It discusses how oxidative phosphorylation provides energy but requires proteins encoded by both nuclear and mitochondrial DNA. Mitochondrial diseases can result from defects in either genome. The review focuses on diseases caused by problems with translating the 13 proteins encoded by mitochondrial DNA. It describes the structure and function of the mitochondrial respiratory chain complexes and DNA. The majority of mitochondrial proteins are nuclear-encoded and involved in processes like respiratory chain assembly and translation of mitochondrial proteins. Defects in these nuclear genes can also cause mitochondrial diseases.
Fuel cells powered by hydrogen are seen as a key energy solution for the 21st century due to their reduced environmental impact and potential to contribute to energy security. Proton exchange membrane (PEM) fuel cells in particular have been developed for applications in transportation, distributed power generation, and energy storage. However, for widespread adoption challenges remain around transitioning from fossil fuels to a hydrogen economy and developing fuel cell membranes that can operate under more demanding conditions required for automotive and stationary applications like higher temperatures and lower humidity levels. Meeting these challenges will require new membrane materials with sufficient conductivity at low humidity and mechanical reinforcement to withstand operating stresses.
This document discusses endoplasmic reticulum (ER) stress and dysfunction. It begins by describing the role of the ER in protein folding and how ER stress occurs when misfolded proteins accumulate. This triggers the unfolded protein response (UPR) to restore homeostasis. Prolonged ER stress can lead to cell death. The document then discusses how ER stress is implicated in various disorders like diabetes and neurodegenerative diseases. It provides details on cerebral hypoxia, describing the types and symptoms, and short and long-term effects of oxygen deprivation in the brain. Treatment focuses on the underlying cause and managing symptoms through therapy.
1) The document analyzes long-term groundwater nitrate measurements from Denmark over the past 70 years to assess the sustainability of intensive agricultural nitrogen (N) management in relation to groundwater protection and economic growth.
2) National and European policy initiatives since the 1980s have pushed agricultural N management in Denmark towards more environmentally sustainable practices to protect groundwater from nitrate pollution resulting from excessive N losses.
3) Groundwater nitrate levels correlate strongly with annual agricultural N surpluses. Improved N management has significantly decreased nitrate levels in some areas, although many still exceed groundwater standards. Further measures are needed for more sustainable N use.
This document discusses the pre-processing of groundwater data from monitoring points over eight years to measure nitrate levels. Specific water samples are selected based on nitrate, iron, and oxygen concentrations to minimize uncertainty and enable nitrate sampling years to be converted to groundwater recharge years. This allows for comparison of long-term changes in nitrogen surplus from agriculture to changes in groundwater nitrate levels. Agricultural nitrogen balances of inputs and outputs are also calculated as an indicator of nitrogen lost to the environment. Nitrate pollution levels in groundwater are then evaluated against economic growth rates to examine an environmental curve.
This document discusses whether nuclear energy should be considered a renewable or non-renewable energy source. While nuclear energy is based on finite uranium sources, some argue it could be considered renewable if fuel sources like thorium are used. However, others counter that uranium deposits are still limited and nuclear waste storage poses challenges. The debate ultimately comes down to definitions of renewable energy and whether nuclear power can meet requirements like having a sustainably replenished fuel source and avoiding harmful pollution.
The document provides an overview of slaughterhouse policies and procedures in Pakistan. It discusses the general unorganized nature of the meat industry historically and outlines requirements for animals, slaughterers, tools, and facilities. The production process is described including animal intake, slaughter, inspection, and distribution. Suggestions are provided related to cleanliness, waste removal, and siting slaughterhouses away from residential areas.
This document summarizes and compares traditional and industrial agricultural systems. Traditional systems are less integrated into markets, rely more on natural capital and agricultural biodiversity, and focus on risk minimization through crop diversity. Industrial systems are more market-integrated, rely more on external inputs and education, focus on maximizing profits through monocultures, and have lower agricultural biodiversity overall. Both systems can contain elements of each other.
The Global Change Impact Studies Centre (GCISC) is a Pakistani research institute focused on climate change studies. It conducts research on past and projected climate changes in Pakistan and their impacts. Key areas of research include climate modeling, climate extremes, and greenhouse gas emissions analysis. Over the last decade, GCISC has led several international collaborative projects on topics like climate-smart agriculture, food and water security, and glacier impacts. GCISC also contributes to national climate policy documents and assessments. Its research activities examine issues like monsoon variability, heat waves, water resources, glaciers, and hydrological projections under climate change.
This document provides an overview of the shampoo industry, including definitions, history, types of shampoos, formulations, raw materials, manufacturing process, and evaluation methods. It discusses the key ingredients in shampoo such as water, detergents, thickeners, and conditioning agents. The manufacturing process involves compounding large batches according to a formula, quality control testing, and filling and packaging individual bottles on a high-speed production line. Shampoos are evaluated based on their foam stability, cleaning power, conditioning effects, and irritation levels.
The document outlines the key aspects of an environmental management system for Metro Cash & Carry, including establishing a committee to review objectives and programs regarding environmental and operational controls. The system aims to identify and reduce negative environmental, health, and safety impacts across the product lifecycle from design to disposal. It also involves keeping an up-to-date register of legal requirements, defining responsibilities, and committing resources to support the effective implementation and maintenance of the system.
Integrating health and biodiversity aims to promote public health and prevent disease through conservation and sustainable use of biodiversity. It recognizes that biodiversity loss and ecosystem degradation negatively impact human health through increased risks of diseases, pollution, and lack of traditional foods and medicines. Achieving integration requires joint efforts across government ministries and sectors to address the environmental and social drivers of biodiversity loss and implement strategies like ecosystem management, controlling invasive species, and promoting sustainable lifestyles. Monitoring progress through indicators will help facilitate timely, evidence-based decisions and global coordination on integrated health and biodiversity goals.
This document outlines various tests used to evaluate properties of shampoo such as foam and foam stability, cleaning ability, effect of water hardness, surface tension, surfactant content, rinsing ability, conditioning effects on softness and luster, lubricity, body and texture, irritation and toxicity, dandruff control, and eye irritancy. It describes several methods for testing these properties, including the Ross-Miles foam column test, lather meter test, canvas disk sinking test, and tests involving human hair, rabbit eyes, and a Brookefield viscometer.
The document discusses the environmental policy of Centaurus Mall in Islamabad, Pakistan. It implemented a policy to charge single men a Rs. 500 non-refundable entry fee to control loitering in the mall. The policy was formulated through identifying the need, assigning a lead responsibility committee, gathering information, drafting and consulting on the policy, finalizing it, and establishing procedures for implementation, monitoring, and reporting.
Metro Cash and Carry submitted an environmental management report to outline their policies and procedures. The report discusses Metro's commitment to sustainability across their supply chain and operations. It provides details on Metro's sustainable sourcing policies for products like palm oil and seafood. The report also describes Metro's energy and resource management efforts, such as using renewable energy and optimizing equipment for energy efficiency. It concludes with recommendations, such as conducting product life cycle reviews and establishing an environmental management committee.
- Biofilms are groups of microorganisms that attach to each other and often surfaces, and are found nearly everywhere in nature. They can include bacteria, fungi, and protists. Common examples are dental plaque and pond scum.
- Biofilm formation is a complex, multi-step process involving initial attachment, microcolony formation within an extracellular matrix, maturation, and eventual dispersal or detachment of cells. Dispersal allows biofilms to spread and colonize new surfaces.
- Biofilms grow in many habitats and can cause problems like infections, corrosion, and difficulties with sanitation. They are implicated in about 80% of all infections and can involve both gram-positive and gram-negative bacteria as
Aldehydes such as formaldehyde and glutaraldehyde have wide antimicrobial properties including being sporicidal and fungicidal. However, glutaraldehyde resistance has emerged in some bacteria and it can cause health issues, leading ortho-phthalaldehyde to replace it. Formaldehyde is used as a disinfectant and biocide, including for vaccines and urinary tract infections. Glutaraldehyde is a non-volatile disinfectant preferred over formaldehyde, used in concentrations of 0.1-1.0% as a biocide and sterilant. Ortho-phthalaldehyde is commonly used to disinfect medical instruments.
This document discusses the links between biodiversity and human health. It begins by defining biodiversity and health, then explores the various interactions between the two. Biodiversity supports human health through ecosystem services like fresh water provision, food production, regulation of infectious diseases, and provision of medicines. Loss of biodiversity can negatively impact these services and human well-being. The social dimensions are also discussed, as vulnerable populations tend to be most affected by biodiversity loss. Unsustainable practices like water pollution from agriculture threaten both ecosystem and human health. Maintaining biodiversity is important for sustaining these services that support livelihoods and quality of life.
The document discusses the Zero Point Interchange Project in Islamabad, Pakistan. The project involved constructing an interchange at the intersection of two major roads, Islamabad Highway and Kashmir Highway. The $300 million project was a mega project undertaken by the Capital Development Authority to improve road networks and create barrier-free avenues and underpasses in the capital. The cloverleaf interchange was completed over 24 months from September 2008 to September 2010.
Paper and Pulp Industry- Pollution Control TechniquesAsh Hassan
The paper and pulp industry generates significant pollution from its production processes. Wastewater contains high levels of organic materials, dark coloration, and toxic pollutants. Solid wastes like treatment sludges also cause issues due to organic content and trace heavy metals. Air emissions release sulfur oxides, nitrogen oxides, and volatile organic compounds. Modern strategies aim to minimize waste through chemical recycling, improved technologies, and end-of-pipe treatments like biological wastewater treatment before discharge or disposal.
This document discusses technologies for genome engineering including MAGE and CAGE. MAGE allows for introducing multiple genetic changes at multiple locations while CAGE uses bacterial conjugation to produce extensively modified genomes. The goal is to achieve virus resistance, genetic isolation, and stable expansion of the genetic code. This involves artificially modifying the genetic code by reassigning codons to encode non-standard amino acids. Challenges include overcoming the conservation and complexity of the genetic code as well as biochemical constraints within the cell.
Kyoto protocol with respect to Pakistan- pptAsh Hassan
This document discusses Pakistan's potential adoption of the Kyoto Protocol to address climate change. It outlines several steps Pakistan could take to implement the protocol, including identifying knowledge of the protocol, developing demonstration projects, providing incentives, and developing renewable energy resources through various government agencies and financing institutions. While the Kyoto Protocol aims to reduce greenhouse gas emissions, on its own it may not provide a real solution to climate change issues. Developing countries will need to take a leadership role in developing durable climate change solutions.
The document discusses the genetic code, which specifies how DNA is used to produce proteins. It covers the discovery of the genetic code in the 1960s and defines key concepts like codons, reading frames, and types of genetic mutations. It also discusses efforts to engineer expanded genetic codes by techniques like codon suppression, reassignment, and creation to incorporate unnatural amino acids. Challenges include overcoming barriers at the biochemical, genetic, and engineering levels while maintaining an organism's fitness. The genetic code continues evolving and has applications in fields like synthetic biology, therapeutics, and vaccine development.
A measles outbreak originating in West Texas has been linked to confirmed cases in New Mexico, with additional cases reported in Oklahoma and Kansas. 61 individuals have required hospitalization, and 3 deaths, 2 children in Texas and 1 adult in New Mexico. These fatalities mark the first measles-related deaths in the United States since 2015 and the first pediatric measles death since 2003.
The YSPH Virtual Medical Operations Center Briefs (VMOC) were created as a service-learning project by faculty and graduate students at the Yale School of Public Health in response to the 2010 Haiti Earthquake. Each year, the VMOC Briefs are produced by students enrolled in Environmental Health Science Course 581 - Public Health Emergencies: Disaster Planning and Response. These briefs compile diverse information sources – including status reports, maps, news articles, and web content– into a single, easily digestible document that can be widely shared and used interactively. Key features of this report include:
- Comprehensive Overview: Provides situation updates, maps, relevant news, and web resources.
- Accessibility: Designed for easy reading, wide distribution, and interactive use.
- Collaboration: The “unlocked" format enables other responders to share, copy, and adapt it seamlessly.
The students learn by doing, quickly discovering how and where to find critical information and presenting it in an easily understood manner.
This document discusses the pre-processing of groundwater data from monitoring points over eight years to measure nitrate levels. Specific water samples are selected based on nitrate, iron, and oxygen concentrations to minimize uncertainty and enable nitrate sampling years to be converted to groundwater recharge years. This allows for comparison of long-term changes in nitrogen surplus from agriculture to changes in groundwater nitrate levels. Agricultural nitrogen balances of inputs and outputs are also calculated as an indicator of nitrogen lost to the environment. Nitrate pollution levels in groundwater are then evaluated against economic growth rates to examine an environmental curve.
This document discusses whether nuclear energy should be considered a renewable or non-renewable energy source. While nuclear energy is based on finite uranium sources, some argue it could be considered renewable if fuel sources like thorium are used. However, others counter that uranium deposits are still limited and nuclear waste storage poses challenges. The debate ultimately comes down to definitions of renewable energy and whether nuclear power can meet requirements like having a sustainably replenished fuel source and avoiding harmful pollution.
The document provides an overview of slaughterhouse policies and procedures in Pakistan. It discusses the general unorganized nature of the meat industry historically and outlines requirements for animals, slaughterers, tools, and facilities. The production process is described including animal intake, slaughter, inspection, and distribution. Suggestions are provided related to cleanliness, waste removal, and siting slaughterhouses away from residential areas.
This document summarizes and compares traditional and industrial agricultural systems. Traditional systems are less integrated into markets, rely more on natural capital and agricultural biodiversity, and focus on risk minimization through crop diversity. Industrial systems are more market-integrated, rely more on external inputs and education, focus on maximizing profits through monocultures, and have lower agricultural biodiversity overall. Both systems can contain elements of each other.
The Global Change Impact Studies Centre (GCISC) is a Pakistani research institute focused on climate change studies. It conducts research on past and projected climate changes in Pakistan and their impacts. Key areas of research include climate modeling, climate extremes, and greenhouse gas emissions analysis. Over the last decade, GCISC has led several international collaborative projects on topics like climate-smart agriculture, food and water security, and glacier impacts. GCISC also contributes to national climate policy documents and assessments. Its research activities examine issues like monsoon variability, heat waves, water resources, glaciers, and hydrological projections under climate change.
This document provides an overview of the shampoo industry, including definitions, history, types of shampoos, formulations, raw materials, manufacturing process, and evaluation methods. It discusses the key ingredients in shampoo such as water, detergents, thickeners, and conditioning agents. The manufacturing process involves compounding large batches according to a formula, quality control testing, and filling and packaging individual bottles on a high-speed production line. Shampoos are evaluated based on their foam stability, cleaning power, conditioning effects, and irritation levels.
The document outlines the key aspects of an environmental management system for Metro Cash & Carry, including establishing a committee to review objectives and programs regarding environmental and operational controls. The system aims to identify and reduce negative environmental, health, and safety impacts across the product lifecycle from design to disposal. It also involves keeping an up-to-date register of legal requirements, defining responsibilities, and committing resources to support the effective implementation and maintenance of the system.
Integrating health and biodiversity aims to promote public health and prevent disease through conservation and sustainable use of biodiversity. It recognizes that biodiversity loss and ecosystem degradation negatively impact human health through increased risks of diseases, pollution, and lack of traditional foods and medicines. Achieving integration requires joint efforts across government ministries and sectors to address the environmental and social drivers of biodiversity loss and implement strategies like ecosystem management, controlling invasive species, and promoting sustainable lifestyles. Monitoring progress through indicators will help facilitate timely, evidence-based decisions and global coordination on integrated health and biodiversity goals.
This document outlines various tests used to evaluate properties of shampoo such as foam and foam stability, cleaning ability, effect of water hardness, surface tension, surfactant content, rinsing ability, conditioning effects on softness and luster, lubricity, body and texture, irritation and toxicity, dandruff control, and eye irritancy. It describes several methods for testing these properties, including the Ross-Miles foam column test, lather meter test, canvas disk sinking test, and tests involving human hair, rabbit eyes, and a Brookefield viscometer.
The document discusses the environmental policy of Centaurus Mall in Islamabad, Pakistan. It implemented a policy to charge single men a Rs. 500 non-refundable entry fee to control loitering in the mall. The policy was formulated through identifying the need, assigning a lead responsibility committee, gathering information, drafting and consulting on the policy, finalizing it, and establishing procedures for implementation, monitoring, and reporting.
Metro Cash and Carry submitted an environmental management report to outline their policies and procedures. The report discusses Metro's commitment to sustainability across their supply chain and operations. It provides details on Metro's sustainable sourcing policies for products like palm oil and seafood. The report also describes Metro's energy and resource management efforts, such as using renewable energy and optimizing equipment for energy efficiency. It concludes with recommendations, such as conducting product life cycle reviews and establishing an environmental management committee.
- Biofilms are groups of microorganisms that attach to each other and often surfaces, and are found nearly everywhere in nature. They can include bacteria, fungi, and protists. Common examples are dental plaque and pond scum.
- Biofilm formation is a complex, multi-step process involving initial attachment, microcolony formation within an extracellular matrix, maturation, and eventual dispersal or detachment of cells. Dispersal allows biofilms to spread and colonize new surfaces.
- Biofilms grow in many habitats and can cause problems like infections, corrosion, and difficulties with sanitation. They are implicated in about 80% of all infections and can involve both gram-positive and gram-negative bacteria as
Aldehydes such as formaldehyde and glutaraldehyde have wide antimicrobial properties including being sporicidal and fungicidal. However, glutaraldehyde resistance has emerged in some bacteria and it can cause health issues, leading ortho-phthalaldehyde to replace it. Formaldehyde is used as a disinfectant and biocide, including for vaccines and urinary tract infections. Glutaraldehyde is a non-volatile disinfectant preferred over formaldehyde, used in concentrations of 0.1-1.0% as a biocide and sterilant. Ortho-phthalaldehyde is commonly used to disinfect medical instruments.
This document discusses the links between biodiversity and human health. It begins by defining biodiversity and health, then explores the various interactions between the two. Biodiversity supports human health through ecosystem services like fresh water provision, food production, regulation of infectious diseases, and provision of medicines. Loss of biodiversity can negatively impact these services and human well-being. The social dimensions are also discussed, as vulnerable populations tend to be most affected by biodiversity loss. Unsustainable practices like water pollution from agriculture threaten both ecosystem and human health. Maintaining biodiversity is important for sustaining these services that support livelihoods and quality of life.
The document discusses the Zero Point Interchange Project in Islamabad, Pakistan. The project involved constructing an interchange at the intersection of two major roads, Islamabad Highway and Kashmir Highway. The $300 million project was a mega project undertaken by the Capital Development Authority to improve road networks and create barrier-free avenues and underpasses in the capital. The cloverleaf interchange was completed over 24 months from September 2008 to September 2010.
Paper and Pulp Industry- Pollution Control TechniquesAsh Hassan
The paper and pulp industry generates significant pollution from its production processes. Wastewater contains high levels of organic materials, dark coloration, and toxic pollutants. Solid wastes like treatment sludges also cause issues due to organic content and trace heavy metals. Air emissions release sulfur oxides, nitrogen oxides, and volatile organic compounds. Modern strategies aim to minimize waste through chemical recycling, improved technologies, and end-of-pipe treatments like biological wastewater treatment before discharge or disposal.
This document discusses technologies for genome engineering including MAGE and CAGE. MAGE allows for introducing multiple genetic changes at multiple locations while CAGE uses bacterial conjugation to produce extensively modified genomes. The goal is to achieve virus resistance, genetic isolation, and stable expansion of the genetic code. This involves artificially modifying the genetic code by reassigning codons to encode non-standard amino acids. Challenges include overcoming the conservation and complexity of the genetic code as well as biochemical constraints within the cell.
Kyoto protocol with respect to Pakistan- pptAsh Hassan
This document discusses Pakistan's potential adoption of the Kyoto Protocol to address climate change. It outlines several steps Pakistan could take to implement the protocol, including identifying knowledge of the protocol, developing demonstration projects, providing incentives, and developing renewable energy resources through various government agencies and financing institutions. While the Kyoto Protocol aims to reduce greenhouse gas emissions, on its own it may not provide a real solution to climate change issues. Developing countries will need to take a leadership role in developing durable climate change solutions.
The document discusses the genetic code, which specifies how DNA is used to produce proteins. It covers the discovery of the genetic code in the 1960s and defines key concepts like codons, reading frames, and types of genetic mutations. It also discusses efforts to engineer expanded genetic codes by techniques like codon suppression, reassignment, and creation to incorporate unnatural amino acids. Challenges include overcoming barriers at the biochemical, genetic, and engineering levels while maintaining an organism's fitness. The genetic code continues evolving and has applications in fields like synthetic biology, therapeutics, and vaccine development.
A measles outbreak originating in West Texas has been linked to confirmed cases in New Mexico, with additional cases reported in Oklahoma and Kansas. 61 individuals have required hospitalization, and 3 deaths, 2 children in Texas and 1 adult in New Mexico. These fatalities mark the first measles-related deaths in the United States since 2015 and the first pediatric measles death since 2003.
The YSPH Virtual Medical Operations Center Briefs (VMOC) were created as a service-learning project by faculty and graduate students at the Yale School of Public Health in response to the 2010 Haiti Earthquake. Each year, the VMOC Briefs are produced by students enrolled in Environmental Health Science Course 581 - Public Health Emergencies: Disaster Planning and Response. These briefs compile diverse information sources – including status reports, maps, news articles, and web content– into a single, easily digestible document that can be widely shared and used interactively. Key features of this report include:
- Comprehensive Overview: Provides situation updates, maps, relevant news, and web resources.
- Accessibility: Designed for easy reading, wide distribution, and interactive use.
- Collaboration: The “unlocked" format enables other responders to share, copy, and adapt it seamlessly.
The students learn by doing, quickly discovering how and where to find critical information and presenting it in an easily understood manner.
Introduction- Quorum Sensing (QS) is a cell-to-cell communication mechanism used by bacteria to regulate gene expression in response to population density.
Historical background - Kenneth Nealson, Terry Platt, and J. Woodland Hastings (1970) - Discovered density-dependent bioluminescence in Aliivibrio fischeri
Bonnie Bassler -Discovered Autoinducer-2 (AI-2), a universal quorum sensing molecule that enables interspecies bacterial communication.
Mechanism of quorum sensing-
Signal Production
Signal Accumulation
Signal Detection
Gene Activation
Types of quorum sensing systems-
Gram-Negative Bacteria
Gram-Positive Bacteria
Autoinducer-2 (AI-2) System
Applications
Case study
The 90's Filler Quiz hosted by Shubham Mourya and T. GaneshKrishna at Hindu Quizzing Championship 2025 for Manthan - The Quizzing Society of Hindu College
A measles outbreak originating in West Texas has been linked to confirmed cases in New Mexico, with additional cases reported in Oklahoma and Kansas. The current case count is 739 from Texas, New Mexico, Oklahoma, and Kansas. 71 individuals have required hospitalization, and 3 deaths, 2 children in Texas and one adult in New Mexico. These fatalities mark the first measles-related deaths in the United States since 2015 and the first pediatric measles death since 2003.
The YSPH Virtual Medical Operations Center Briefs (VMOC) were created as a service-learning project by faculty and graduate students at the Yale School of Public Health in response to the 2010 Haiti Earthquake. Each year, the VMOC Briefs are produced by students enrolled in Environmental Health Science Course 581 - Public Health Emergencies: Disaster Planning and Response. These briefs compile diverse information sources – including status reports, maps, news articles, and web content– into a single, easily digestible document that can be widely shared and used interactively. Key features of this report include:
- Comprehensive Overview: Provides situation updates, maps, relevant news, and web resources.
- Accessibility: Designed for easy reading, wide distribution, and interactive use.
- Collaboration: The “unlocked" format enables other responders to share, copy, and adapt seamlessly.
The students learn by doing, quickly discovering how and where to find critical information and presenting it in an easily understood manner.
Prelims of the India Quiz hosted by Ripesh Ghosh , Harit Jain and Sameer Upadhyay at Hindu Quizzing Championship 2025 for Manthan - The Quizzing Society of Hindu College
ĐỀ CƯƠNG HK2 LỚP 7. cuoi ky 2 thcs hoa phuNhiLinh58
Nếu bạn đang làm kế toán, tài chính, hoặc xử lý nhiều dữ liệu lặp đi lặp lại, thì học VBA sẽ giúp tiết kiệm thời gian và nâng cao hiệu suất công việc rõ rệt.
The anarchy that spread in northern India after Harsha's death also affected Bengal. After Shashank's death, no powerful king emerged in Bengal for a long time. As a result, there was political instability in Bengal for about 100 years. The Khalimpur inscription reveals that during this period, Matsyanyaya was prevalent there under which the strong were oppressing the weak. Frightened by this anarchy, the people of Bengal made a commander named Gopal their king. This is an important example of the election of a king by the people. Gopal ended the anarchy in Bengal and laid the foundation of a new dynasty. This dynasty is famous by the name of Pala.
A free workshop/Spring Session
A Guide 2
REiki- Yoga
We are all energy.
We host the same powers.
We can declare, demand, delete anything we want. We are programmed to not understand this Power.
Beyond Metaphysics:
My world has expanded to Yoga Fitness than therapy, Basic Feng Shui, Fusing Qigong, and Recently Regrouping with Reiki as a Practitioner Master. All branches are Energy Medicine. They are ways of Healing the Mind, Body, Soul, and Heart. Our bodies are energy Temples. We misunderstand the term Temple.
(See Presentation for all sections)
Starting Your Daily Practice:
Both Reiki and Yoga are effortless, ebb flow practices. The fusion does work, therapy wonders. Session Times will vary. For Example: Using a few minutes, 30 mins, to hours of Reiki Yoga can be applied. I would start small? Try to build your practice slowly. There’s no rush. Poses Include Laying Down or sitting within Meditation….
(See Presentation for all sections)
Benefits of: Nature / Deep Breathing...
This may sound simple or basic. But, don’t forget to enjoy fresh air from your doors, windows, yard, taking walks, or even the local park. It does aid the healing process and any meditation style. Also, any breathing method used will assist both your Reiki and Yoga. (They work together nicely as a team or partnership.) The body refreshes instantly. It helps with calming down and relaxing.
♥¸.•♥ ♥¸.•♥
- https://ldm-mia.creator-spring.com
- https://ko-fi.com/ldmmia
♥¸.•♥ ♥¸.•♥
https://www.instagram.com/chelleofsl/
https://x.com/OnlineDrLeZ
B.Ed. First Year Semester IA. Meaning, Concept, Nature & ScopeProfDrShaikhImran
Geography can be called as an ancient subject, it can be related to the Greeks who gave immense importance to it. Greeks were the early voyagers known for their sea faring skills, they were the early explorers travelling the length and breadth of Mediterranean sea for trade. Returning back from the expeditions, these voyagers use to narrate details of their observation and experiences to the local people. In this way gradually Geography took shape as a discipline.
1. RISE OF GUPTA EMPIRE
The Gupta Empire, founded by Maharaja Sri Gupta, was an ancient Indian realm that covered
much of the Indian Subcontinent from approximately 320-550 CE. Gupta rule, while solidified
by territorial expansion through war, began a period of peace and prosperity marked by
advancements in science, technology, engineering, art, dialectics, literature, logic, mathematics,
astronomy, religion, and philosophy.
GUPTA EMPIRE ORIGINS
The Gupta Empire was believed to be a dynasty of the Vaishya caste, the third of the four Hindu
castes representing merchants and farmers. Founded by Sri Gupta c. 240-280 CE, there are
contradictory theories regarding the original homeland of the Guptas. Historians believe Sri
Gupta and his son may have been Kushan vassals, or rulers who swore allegiance to the Kushan
Empire. Sri Gupta's son and successor, Ghatotkacha, ruled from c. 280-319 CE, while his son,
Chandragupta, ascended the throne around 319 and ruled until 335 CE.
Chandragupta married princess Kumaradevi from the Kingdom of Magadha, which was one of
the Mahajanapadas (or great countries) of ancient India during the 4th century CE. With a dowry
and political alliance from the marriage, Chandragupta conquered or assimilated the kingdoms of
Magadha, Prayaga, and Saketa. By 321 CE, he established a realm stretching along the Ganges
River to Prayag, the modern-day city of Allahabad, in the Indian state of Uttar Pradesh. Hindus
believe the god Brahma offered his first sacrifice after creating the world at Prayag.
Queen Kumaradevi and King
Chandragupta I
A coin from the period of Indian Emperor
Samudragupta, 335-380 CE, depicting his
parents, King Chandragupta and Queen
Kumaradevi.
GUPTA EMPIRE EXPANSION
Samudragupta succeeded his father, Chandragupta I, in 335 CE, and ruled for about 45 years. He
conquered the kingdoms of Ahichchhatra and Padmavati early in his reign, then attacked
neighboring tribes, including the Malwas, Yaudheyas, Arjunayanas, Maduras, and Abhiras. By
his death in 380 CE, Samudragupta had incorporated over 20 kingdoms into his realm, and
extended the Gupta Empire from the Himalayas to the Narmada River in central India, and from
the Brahmaputra River that cuts through four modern Asian nations to the Yamuna— the longest
tributary of the Ganges River in northern India.
To celebrate his conquest, Samudragupta performed the royal Vedic ritual of Ashwamedha, or
horse sacrifice. Special coins were minted to commemorate the Ashvamedha, and the king took
the title of Maharajadhiraja (or “King of Kings”) even higher than the traditional ruler’s title of
Maharaja.
According to the Gupta records, Samudragupta nominated his son, Prince Chandragupta II, born
of Queen Dattadevi, as his successor. However, his eldest son, Ramagupta, may have been his
immediate successor until he was dethroned by Chandragupta II in 380 CE.
2. GUPTA EMPIRE OF CHANDRAGUPTAII
After gaining power, Chandragupta II expanded the Gupta Empire through conquest and political
marriages until the end of his reign in 413 CE. By 395 CE, his control over India extended coast-
to-coast. At the high point of his rule, Chandragupta II established a second capital at Ujjain, the
largest city in the modern state of Madhya Pradesh in central India. Ujjain, on the eastern bank of
the Kshipra River, remained an important political, commercial, and cultural hub through the
early 19th century.
Vikramaditya is the name of an emperor of ancient Indian legend, characterized as the ideal king
known for generosity, courage, and as a patron of scholars. A number of historians believe that
some of these legends are based on Chandragupta II, who is thought to have adopted the title of
Vikramaditya.
In the legends, Vikramaditya is said to have thwarted an invasion by the Saka, a group of eastern
Iranian nomadic tribes, also known as Scythians, and gained the title of Sakari, or Enemy of the
Saka. Chandragupta II conquered the western Indian region of Malwa after defeating the
Western Kshatrapas, a branch of the Sakas, as well as expelling the Kushana Empire from the
northern Indian city state Mathura. These victories were likely transposed onto the legendary
character of Vikramaditya.
Chandragupta II issued gold coin types introduced by his father, Samudragupta, but also
introduced several new types of coins, differentiated by the designs on the face of each coin line,
such as the Archer or the Tiger-Slayer. He was also the first Gupta king to issue silver coins.
One of the most curious structures in Delhi, India (an iron pillar dating back to the 4th century
CE) bears an inscription stating that it was erected as a flagstaff in honor of the Hindu god
Vishnu, and in memory of Chandragupta II. The pillar, made of 98% wrought iron, is considered
a highlight of ancient Indian achievements in metallurgy; it has stood more than 1,600 years
without rusting or decomposing.
Despite the expansion of the Gupta Empire through war, there were numerous examples of
cultural sophistication during the Gupta era, with architecture, sculptures and paintings surviving
as reminders of the creativity of the time. Under Gupta rule, a number of notable scholars
thrived, including Kalidasa, considered the greatest poet and dramatist of the Sanskrit language;
Aryabhata, the first of the Indian mathematician-astronomers who worked on the approximation
for Pi; Vishnu Sharma, thought to be the author of the Panchatantra fables, one of the most
widely-translated, non-religious books in history; and the Hindu philosopher Vatsyayana.
GOLDENAGE OF INDIA
The period of Gupta rule, especially the reign of Chandragupta II, is still remembered as the
Golden Age of India.
The prosperity created under the leadership of the Gupta Empire, which covered much of the
Indian subcontinent from approximately 320-550 CE, enabled the wide pursuit of scientific and
artistic endeavors. This period became known as the Golden Age of India because it was marked
by extensive inventions and discoveries in science, technology, engineering, art, dialectic,
literature, logic, mathematics, astronomy, religion, and philosophy. These discoveries
crystallized elements of what is generally considered Hindu culture.
3. SCIENCE, LITERATURE AND ART
Although Chandragupta I and his son, Samudragupta, were prominent rulers, the reign of
Chandragupta II included the greatest promotion of science, art, philosophy, and religion by the
government. Chandragupta's court was even more influential than those that came before or after
because it contained the Navaratnas, or the Nine Jewels, a group of nine scholars who produced
advancements in many academic fields.
These scholars included Aryabhata, who is believed to have envisioned the concept of zero, as
well as working on the approximation for the long-form number Pi. Aryabhata is also believed to
be the first of the Indian mathematician-astronomers who postulated the theory that the Earth
moves round the Sun and is not flat, but instead is round and rotates on its own axis. He also may
have discovered that the moon and planets shine due to reflected sunlight.
Varahamihira was an astronomer, astrologer, and mathematician, whose main work is a treatise
on mathematical astronomy. Sushruta, a famed Indian physician of the Gupta period, wrote the
Samhita, a Sanskrit text on all of the major concepts of ayurvedic medicine, with innovative
chapters on surgery. Other scholars of the Golden Age helped create the first Indian numeral
systems with a base of ten. The game of chess also likely originated during this period, where its
early form, Chaturanga, contained game pieces for infantry, cavalry, elephants, and chariots,
each of which would evolve into the modern pawn, knight, rook, and bishop, respectively.
Kalidasa, considered the greatest poet and dramatist of the Sanskrit language, also belonged
primarily to this period. He wrote plays, such as Shakuntala, which is said to have inspired the
famed German writer and statesman, Johann von Goethe, centuries later. Kalidasa also became
renowned for his study of the shringara, or romantic, element of literature. The Indian scholar
and Hindu philosopher Vatsyayana, authored the Kama Sutra, which became a standard work on
human sexual behavior, while Vishnu Sharma was thought to be the author of the Panchatantra
fables, one of the most widely-translated, non-religious books in history.
The cultural creativity of the Golden Age of India produced magnificent architecture, including
palaces and temples, as well as sculptures and paintings of the highest quality. The walls of
Buddhist shrines and monasteries were decorated with colorful frescoes, a type of wall paintings.
These showed scenes from the life of the Buddha, the ascetic and philosopher, who lived in the
eastern part of the Indian subcontinent sometime between 6th and 4th centuries, on whose
teachings the Buddhist religion is based. Some shrines were cut out of the cliffs, and although
dark, they were also decorated with sculptures and paintings.
INFLUENCE ON EAST AND SOUTHEAST ASIA
The Gupta Dynasty promoted Hinduism, but supported Buddhist and Jain cultures as well. Gupta
Buddhist art influenced East and Southeast Asia as trade between regions increased. The Gupta
Empire became an important cultural center and influenced nearby kingdoms and regions in
Burma, Sri Lanka, and Southeast Asia. Classical forms of Indian music and dance, created under
the Guptas, are still practiced all over Asia today.
Fa Xian was one of the first Chinese travelers to visit India during the reign of Gupta Emperor
Chandragupta II. He started his journey from China in 399 CE, and reached India in 405 CE. He
recorded all of his observations in a journal that was eventually published.
4. During his stay in India, until c. 411 CE, Fa Xian went on a pilgrimage to Mathura, Kanauj,
Kapilavastu, Kushinagar, Vaishali, Pataliputra, Kashi, and Rajgriha. His writings express
pleasure in the mildness of the administrations in these places.
DECLINE OF GUPTA EMPIRE
The Gupta Empire flourished, in military and territorial conquests as well as cultural and
scholastic advancements, during the reign of Emperor Chandragupta II. Yet the succeeding
rulers, beginning with Kumaragupta I and then Skandagupta, oversaw the eventual end of the
Gupta Empire through military defeats, devalued money and withering leadership.
KUMARAGUPTA
In 415 CE, Chandragupta II was succeeded by his second son, Kumaragupta I, who ruled
successfully until 455 CE. The late years of his reign, however, faced difficulties. The
Pushyamitras, a tribe of central India, rose up in rebellion against Kumaragupta, while Gupta
territories were invaded by the Western Huna people, also known as White Huns.
Kumaragupta defeated both groups and celebrated his victory by performing the royal Vedic
ritual of Ashwamedha, or horse sacrifice, which had previously been performed by his
grandfather, Emperor Samudragupta, to celebrate his own great military victories.
Coin of Kumaragupta I
A silver coin from the reign of Gupta
Emperor Kumaragupta I, c. 415-455 CE.
As his grandfather and father did before him, Kumaragupta also issued news coins to mark his
reign. They were stamped with images of his namesake god, Lord Kumara, regarded by Hindus
as Regent of Earth.
SKANDAGUPTA
Upon Kumaragupta’s death in 455 CE, his son, Skandagupta, assumed the throne and ruled until
c. 467 CE. He is considered the last of the great Gupta rulers prior to the collapse of the empire.
Skandagupta, who was celebrated as a great warrior for his victorious clashes with the Huns
during his father’s reign, defeated several rebellions and external threats from the Huna people,
notably an invasion in 455 CE. Although victorious, the expenses of the wars against the Hunas
drained the empire's resources. The value of the coinage issued under Skandagupta becoming
severely reduced.
5. Coin of Skandagupta
A coin emblazoned with the image of Gupta
Dynasty Emperor Skandagupta, who ruled c.
455-467 CE.
THE HUNA AND GUPTA’S DEMISE
The Huna were a Central Asian Xionite tribe that consisted of four hordes: Northern Huna, also
known as the Black Huns; Southern Huna, the Red Huns; Eastern Huna, the Celestial Huns; and
the White Huns, the Western Huna. The White Huns, those who invaded the Gupta Empire
during the reign of Kumaragupta, were also known as the Hephthalites, and caused great damage
to the failing Gupta Empire. Skandagupta died in 467 CE, and was followed onto the throne by
his half-brother, Purugupta, who ruled from 467-473 CE.
Thereafter came a succession of weak kings, beginning with Kumaragupta II from 473-476 CE,
followed by Budhagupta, the son of Purugupta. The Hephthalites broke through the Gupta
military defenses in the northwest in the 480s, during the reign of Budhagupta, and by 500 CE
much of the empire in northwest was overrun by the Huna.
The empire thereafter disintegrated into numerous regional kingdoms, ruled by chieftains. A
minor line of the Gupta Clan continued to rule Magadha, one of the 16 Indian Mahajanapadas, or
"Great Countries," but the Gupta Empire fell by 550 CE.