Respiratory distress syndrome is a condition in premature infants caused by a lack of surfactant in the lungs. Surfactant is needed to keep the alveoli open during breathing. Without it, lungs collapse during exhalation due to surface tension. This causes respiratory failure. Risk factors include prematurity, meconium aspiration, or maternal complications. Diagnosis involves assessing breathing rate, lung sounds, oxygen needs and chest x-rays. Treatment focuses on providing oxygen, medications, and supportive care until the lungs mature enough to produce surfactant.
A pulmonary embolism occurs when a blood clot forms in the deep veins of the legs or pelvis and travels through the bloodstream, lodging in the pulmonary arteries of the lungs. It can be difficult to diagnose and is a potentially life-threatening condition. Diagnostic tests may include a d-dimer blood test, CT scan, ventilation-perfusion scan, echocardiogram, and angiogram. Treatment involves anticoagulation medications to prevent further clotting and thrombolysis in some severe cases. Prevention by minimizing risk factors for deep vein thrombosis is important.
1. Lung tumors can be classified as primary lung cancers, metastases, or benign tumors. Primary lung cancers include non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), and others.
2. Imaging plays a key role in evaluating lung tumors by characterizing findings, aiding diagnosis, and staging. Features such as size, margins, enhancement, and growth over time provide clues about benign vs malignant tumors.
3. NSCLC is the most common type and demonstrates varied radiological appearances depending on size, location, and histology. Imaging is also used to guide biopsy and assess treatment response.
Neonatal acute respiratory distress syndrome (RDS) is caused by surfactant deficiency in premature infants. Surfactant is produced in the lungs beginning at 24 weeks gestation and helps lower surface tension to prevent alveolar collapse. Preemies are at risk for RDS due to incomplete lung development and surfactant production. Treatment includes supportive care like CPAP, surfactant replacement therapy, and mechanical ventilation if needed. With treatment and lung maturation, symptoms typically improve within 3-5 days.
Neonatal resuscitation program 8 th edition updatesJason Dsouza
1. The document discusses updates to the Neonatal Resuscitation Program 8th edition, including changes to initial steps, umbilical cord management, temperature management, use of alternative airways, assessment of heart rate, and administration of medications like epinephrine.
2. Key updates include reordering initial steps, recommending delayed umbilical cord clamping for at least 30-60 seconds, use of electronic cardiac monitors earlier, and changes to epinephrine flush volumes and doses.
3. The presentation reviews various aspects of newborn resuscitation including preparation, assessment, ventilation, chest compressions, and medications in line with the latest American Heart Association guidelines.
Respiratory physiology & Respiratory Distress syndrome in a newborn.Sonali Paradhi Mhatre
Hi guys, This ppt shows the pathophysiology of pulmonary surfactant in newborn and respiratory distress syndrome. Main focus is towards management of RDS esp. exogenous surfactant administration. Your comments are welcome. Thank you.
The document provides information about urodynamics testing performed at the Department of Urology, Government Royapettah Hospital and Kilpauk Medical College in Chennai. It discusses the professors and assistant professors who moderate the tests. It then describes the purpose and components of urodynamics testing, which involves a series of tests to evaluate urine storage and evacuation. The key components reviewed include uroflowmetry, measurement of post-void residual urine, cystometrogram, pressure flow studies, and videourodynamics. The document provides details on performing each test and interpreting the results.
Testicular torsion is a urological emergency caused by twisting of the spermatic cord, cutting off blood supply to the testicle. It most commonly affects adolescent boys and young men under age 25. Without prompt surgical intervention to untwist the cord within 6-12 hours, the testicle will become necrotic. Diagnosis involves physical exam findings like a high-riding, swollen testicle with absent cremasteric reflex as well as Doppler ultrasound showing reduced or absent blood flow. Immediate orchiopexy is needed to save the testicle from necrosis and allow for potential future fertility.
This document discusses the diagnosis and management of posterior urethral valves. It begins by defining PUV as a congenital obstructing membrane in the urethra that causes lower urinary tract obstruction. PUV is the most common cause of urinary outflow obstruction in pediatric patients and can lead to renal failure if not treated. The document then covers the pathophysiology, prenatal diagnosis, postnatal evaluation and various treatment approaches for PUV including endoscopic valve ablation, vesicostomy, and nephroureterectomy in severe cases.
Vesicoureteral reflux (VUR) is retrograde flow of urine from the bladder to the upper urinary tract. It can be primary due to deficiencies in the ureterovesical junction or secondary due to bladder dysfunction. Diagnosis involves urine tests, ultrasound, VCUG, DMSA scan and urodynamic studies. Most low-grade reflux resolves spontaneously while high-grade reflux is less likely to resolve. Management includes antibiotics and watchful waiting or surgical correction via open or endoscopic techniques like injection of bulking agents. The goal is to prevent urinary tract infections and renal damage.
Etiopathogenesis, Evaluation & Management of Posterior Urethral ValveShubham Lavania
This document discusses posterior urethral valves (PUV), including their etiology, classification, pathophysiology, clinical presentation, diagnosis, and management. PUV are congenital obstructions of the posterior urethra that commonly cause urinary outflow obstruction in boys. Type I valves are the most common. Initial management involves bladder drainage and antibiotics. Surgical valve ablation is usually curative, but long-term sequelae like renal disease are significant due to the primitive tissue injury caused by the obstruction.
Post-obstructive diuresis refers to high urine output that can occur after relief of urinary tract obstruction. It is caused by accumulation of water, sodium, and urea during the period of obstruction. There are two main types - physiological diuresis which is self-limiting as fluid balance returns to normal, and pathological diuresis where inappropriate water loss continues beyond normalization of volume status. Treatment involves careful fluid management to replace losses based on urine output and electrolyte monitoring, as most cases will resolve spontaneously once homeostasis is restored. However, those with risk factors like edema may require closer monitoring and intravenous fluids.
This document discusses pelvi-ureteric junction obstruction (PUJO). It notes that PUJO is the most common site of congenital ureteral obstruction, occurring in about 1 in 1250 births with a male to female ratio of 2:1. PUJO can be either intrinsic, due to adynamic smooth muscle, or extrinsic, due to aberrant vessels or bands. Diagnosis is typically made through antenatal ultrasound showing pelvic dilation or postnatally through ultrasound and renography demonstrating obstruction. Surgical management includes open pyeloplasty techniques or minimally invasive approaches like laparoscopy or endopyelotomy.
This document provides an overview of obstructive uropathy. It begins by defining obstructive uropathy as the functional or anatomic obstruction of urine flow at any level of the urinary tract. It then discusses the prevalence of obstructive uropathy and how it can be classified based on factors like duration and site of obstruction. Potential causes of obstructive uropathy are then reviewed for different parts of the urinary tract. The pathophysiology and hemodynamic changes that occur with obstruction are explained. Cellular and molecular changes that can lead to fibrosis and tubular cell death are described. Management of patients is discussed including diagnostic imaging, issues in patient care like hypertension and pain management, and considerations for surgical intervention.
Approach to Hematuria including:
Definition of Hematuria.
Pathophysiology of Hematuria.
Differential Diagnosis of Red Urine.
Causes of Hematuria.
Approach to a patient with Hematuria.
Diagnostic Algorithms.
Management and Disposition.
Hydronephrosis is the dilation of the renal pelvis and calyces caused by urinary outflow obstruction. It can result from anatomical or functional issues anywhere along the urinary tract. Chronic or severe hydronephrosis can lead to permanent kidney damage if not treated. Treatment depends on the cause and severity but may include ureteral stents, percutaneous nephrostomy tubes, or open surgery to bypass or remove the obstruction. The goal is to relieve obstruction and preserve kidney function.
This document discusses intestinal atresia and obstruction. It begins by defining the two types of intestinal obstruction - simple and strangulating. It then covers the pathophysiology, causes including congenital lesions, clinical presentation depending on location and severity of obstruction, investigations including imaging and labs, and management including initial stabilization, surgery, and specific approaches for different types of atresia like duodenal and jejunal/ileal atresia. It also discusses related conditions like meconium ileus. The document provides detailed information on evaluating and treating neonatal intestinal obstruction.
Fetal hydronephrosis is the most commonly detected fetal anomaly on prenatal ultrasound. It can be caused by obstructive or non-obstructive factors. The main obstructive causes are UPJ obstruction, ureterocele, and posterior urethral valves. Evaluation of fetal kidneys includes measuring the APD of the renal pelvis. For intervention, vesicoamniotic shunting can relieve bladder outlet obstruction but carries risks of shunt failure or preterm labor. While shunting may improve renal function in some cases, long term outcomes often still include renal insufficiency or need for transplant.
- Anorectal malformations (ARMs) range from minor defects to complex anomalies associated with other issues. They occur in approximately 1 in 5,000 births.
- Evaluation of newborns with ARMs involves examining the anus, genitals, and spine. Imaging studies like ultrasound, MRI and contrast enemas are used to characterize the anatomy and identify any associated anomalies in other organ systems.
- Treatment depends on the specific type of ARM, but may involve procedures like colostomy to allow the distal anatomy to develop before definitive repair. The long-term goals are to establish bowel and urinary continence.
POSTERIOR URETHRAL VALVES- Pediatric Surgery
• Dear viewers,
• Greetings from “ Surgical Educator”
• Today I have uploaded one more video in Pediatric Surgery/Pediatric Urology- “ Posterior Urethral Valves”
• Posterior Urethral Valves is the congenital cause for Bladder Outlet Obstruction, resulting in abnormal development of the kidneys as well as the bladder.
• In this video, I talked about the learning outcomes, introduction, etiopathogenesis, clinical features, investigations, differential diagnosis, treatment, follow-up and prognosis of “ Posterior Urethral Valves”
• I hope you will enjoy the video for its educational value.
• You can watch all my teaching videos in the following links
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
This document discusses a horseshoe kidney and percutaneous nephrolithotomy (PCNL) for treating kidney stones in a horseshoe kidney. It begins by defining a horseshoe kidney as two distinct kidney masses connected by an isthmus of tissue across the midline. It then discusses the embryology, incidence, variations, associated anomalies, symptoms, diagnosis and treatment of stones in a horseshoe kidney. Key points are that PCNL is the treatment of choice for large stones (>1.5-2 cm) in a horseshoe kidney due to the anatomy making percutaneous access easier compared to a normal kidney. Access is typically through an upper pole calyx for the best access. Flexible instruments may help reach more
Posterior urethral valves is a congenital condition caused by abnormal membranes in the proximal urethra that obstruct the flow of urine. It most commonly presents in infancy with failure to pass urine and is diagnosed using imaging like ultrasound and voiding cystourethrography. Treatment involves surgical ablation of the valves via cystoscopy to restore urinary flow and halt renal damage. Prognosis depends on factors like age at diagnosis and degree of renal dysfunction, as patients may develop lifelong complications due to the original renal insults.
Meconium ileus is a neonatal intestinal obstruction caused by thickened meconium within the bowel lumen. It occurs in approximately 20% of cystic fibrosis patients and risk factors include a family history of cystic fibrosis or meconium ileus, as well as low birth weight. Thickened meconium leads to obstruction in the bowel, dilation of the proximal ileum, and narrowing of the distal intestine. Symptoms include failure to pass meconium and abdominal distension. Treatment options include non-operative hyperosmolar enemas to break down the thickened meconium or operative resection with enterostomy or primary anastomosis for complicated cases.
This document discusses bladder outlet obstruction (BOO) and its causes such as benign prostatic hyperplasia (BPH). It describes the primary and long term effects of BOO on the bladder, including decreased urinary flow rates and increased voiding pressures. For BPH, it notes the causes include hyperplasia of the prostate gland that typically begins in the third decade. The document outlines the diagnosis, evaluation and treatment of BOO, including medical management with medications like alpha blockers and 5-alpha reductase inhibitors, as well as surgical treatments like transurethral resection of the prostate (TURP).
Hydronephrosis is the dilation of the renal pelvis and calyces caused by obstruction of urine flow from the kidney. It can be caused by issues in the ureter, bladder, or urethra that limit urine outflow. Unilateral hydronephrosis may cause dull flank pain while bilateral obstruction can lead to decreased urine output. Left untreated, hydronephrosis can damage kidney tissue and impair renal function. Diagnosis is made through imaging tests like intravenous pyelogram. Treatment focuses on resolving the underlying cause of obstruction.
Priapism is a prolonged, unwanted erection that continues hours beyond sexual stimulation. There are two main types: ischemic (low-flow) priapism which is painful and involves little blood flow out of the penis, and non-ischemic (high-flow) priapism which is painless and involves an abnormal connection allowing high arterial inflow. Ischemic priapism is a medical emergency requiring aspiration of blood from the penis and injection of medications to induce detumescence within 4-6 hours to prevent permanent erectile dysfunction. Treatment options depend on duration and include aspiration, intracavernosal injections of medications, or surgical shunting if conservative measures fail.
Antenatally detected hydronephrosis is one of the most common abnormalities detected on prenatal ultrasound. It can identify urinary tract obstructions and reflux before complications develop. The degree of hydronephrosis seen on prenatal ultrasound provides prognostic information, with mild cases often resolving and severe cases more likely to require postnatal intervention. Evaluation after birth depends on the severity and laterality of the hydronephrosis seen prenatally, with more severe or bilateral cases warranting earlier and more extensive testing like dynamic renal scintigraphy to assess kidney function and guide management.
Hydronephrosis is the dilation of the renal pelvis and calyces, which can be caused by obstruction of urine flow. It is commonly detected during prenatal ultrasound screening. Common causes in neonates include ureteropelvic junction obstruction, posterior urethral valves, and vesicoureteral reflux. Treatment depends on the severity and includes antibiotics, surgery to repair obstructions, and management of any associated renal issues.
This document discusses the diagnosis and management of posterior urethral valves. It begins by defining PUV as a congenital obstructing membrane in the urethra that causes lower urinary tract obstruction. PUV is the most common cause of urinary outflow obstruction in pediatric patients and can lead to renal failure if not treated. The document then covers the pathophysiology, prenatal diagnosis, postnatal evaluation and various treatment approaches for PUV including endoscopic valve ablation, vesicostomy, and nephroureterectomy in severe cases.
Vesicoureteral reflux (VUR) is retrograde flow of urine from the bladder to the upper urinary tract. It can be primary due to deficiencies in the ureterovesical junction or secondary due to bladder dysfunction. Diagnosis involves urine tests, ultrasound, VCUG, DMSA scan and urodynamic studies. Most low-grade reflux resolves spontaneously while high-grade reflux is less likely to resolve. Management includes antibiotics and watchful waiting or surgical correction via open or endoscopic techniques like injection of bulking agents. The goal is to prevent urinary tract infections and renal damage.
Etiopathogenesis, Evaluation & Management of Posterior Urethral ValveShubham Lavania
This document discusses posterior urethral valves (PUV), including their etiology, classification, pathophysiology, clinical presentation, diagnosis, and management. PUV are congenital obstructions of the posterior urethra that commonly cause urinary outflow obstruction in boys. Type I valves are the most common. Initial management involves bladder drainage and antibiotics. Surgical valve ablation is usually curative, but long-term sequelae like renal disease are significant due to the primitive tissue injury caused by the obstruction.
Post-obstructive diuresis refers to high urine output that can occur after relief of urinary tract obstruction. It is caused by accumulation of water, sodium, and urea during the period of obstruction. There are two main types - physiological diuresis which is self-limiting as fluid balance returns to normal, and pathological diuresis where inappropriate water loss continues beyond normalization of volume status. Treatment involves careful fluid management to replace losses based on urine output and electrolyte monitoring, as most cases will resolve spontaneously once homeostasis is restored. However, those with risk factors like edema may require closer monitoring and intravenous fluids.
This document discusses pelvi-ureteric junction obstruction (PUJO). It notes that PUJO is the most common site of congenital ureteral obstruction, occurring in about 1 in 1250 births with a male to female ratio of 2:1. PUJO can be either intrinsic, due to adynamic smooth muscle, or extrinsic, due to aberrant vessels or bands. Diagnosis is typically made through antenatal ultrasound showing pelvic dilation or postnatally through ultrasound and renography demonstrating obstruction. Surgical management includes open pyeloplasty techniques or minimally invasive approaches like laparoscopy or endopyelotomy.
This document provides an overview of obstructive uropathy. It begins by defining obstructive uropathy as the functional or anatomic obstruction of urine flow at any level of the urinary tract. It then discusses the prevalence of obstructive uropathy and how it can be classified based on factors like duration and site of obstruction. Potential causes of obstructive uropathy are then reviewed for different parts of the urinary tract. The pathophysiology and hemodynamic changes that occur with obstruction are explained. Cellular and molecular changes that can lead to fibrosis and tubular cell death are described. Management of patients is discussed including diagnostic imaging, issues in patient care like hypertension and pain management, and considerations for surgical intervention.
Approach to Hematuria including:
Definition of Hematuria.
Pathophysiology of Hematuria.
Differential Diagnosis of Red Urine.
Causes of Hematuria.
Approach to a patient with Hematuria.
Diagnostic Algorithms.
Management and Disposition.
Hydronephrosis is the dilation of the renal pelvis and calyces caused by urinary outflow obstruction. It can result from anatomical or functional issues anywhere along the urinary tract. Chronic or severe hydronephrosis can lead to permanent kidney damage if not treated. Treatment depends on the cause and severity but may include ureteral stents, percutaneous nephrostomy tubes, or open surgery to bypass or remove the obstruction. The goal is to relieve obstruction and preserve kidney function.
This document discusses intestinal atresia and obstruction. It begins by defining the two types of intestinal obstruction - simple and strangulating. It then covers the pathophysiology, causes including congenital lesions, clinical presentation depending on location and severity of obstruction, investigations including imaging and labs, and management including initial stabilization, surgery, and specific approaches for different types of atresia like duodenal and jejunal/ileal atresia. It also discusses related conditions like meconium ileus. The document provides detailed information on evaluating and treating neonatal intestinal obstruction.
Fetal hydronephrosis is the most commonly detected fetal anomaly on prenatal ultrasound. It can be caused by obstructive or non-obstructive factors. The main obstructive causes are UPJ obstruction, ureterocele, and posterior urethral valves. Evaluation of fetal kidneys includes measuring the APD of the renal pelvis. For intervention, vesicoamniotic shunting can relieve bladder outlet obstruction but carries risks of shunt failure or preterm labor. While shunting may improve renal function in some cases, long term outcomes often still include renal insufficiency or need for transplant.
- Anorectal malformations (ARMs) range from minor defects to complex anomalies associated with other issues. They occur in approximately 1 in 5,000 births.
- Evaluation of newborns with ARMs involves examining the anus, genitals, and spine. Imaging studies like ultrasound, MRI and contrast enemas are used to characterize the anatomy and identify any associated anomalies in other organ systems.
- Treatment depends on the specific type of ARM, but may involve procedures like colostomy to allow the distal anatomy to develop before definitive repair. The long-term goals are to establish bowel and urinary continence.
POSTERIOR URETHRAL VALVES- Pediatric Surgery
• Dear viewers,
• Greetings from “ Surgical Educator”
• Today I have uploaded one more video in Pediatric Surgery/Pediatric Urology- “ Posterior Urethral Valves”
• Posterior Urethral Valves is the congenital cause for Bladder Outlet Obstruction, resulting in abnormal development of the kidneys as well as the bladder.
• In this video, I talked about the learning outcomes, introduction, etiopathogenesis, clinical features, investigations, differential diagnosis, treatment, follow-up and prognosis of “ Posterior Urethral Valves”
• I hope you will enjoy the video for its educational value.
• You can watch all my teaching videos in the following links
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
This document discusses a horseshoe kidney and percutaneous nephrolithotomy (PCNL) for treating kidney stones in a horseshoe kidney. It begins by defining a horseshoe kidney as two distinct kidney masses connected by an isthmus of tissue across the midline. It then discusses the embryology, incidence, variations, associated anomalies, symptoms, diagnosis and treatment of stones in a horseshoe kidney. Key points are that PCNL is the treatment of choice for large stones (>1.5-2 cm) in a horseshoe kidney due to the anatomy making percutaneous access easier compared to a normal kidney. Access is typically through an upper pole calyx for the best access. Flexible instruments may help reach more
Posterior urethral valves is a congenital condition caused by abnormal membranes in the proximal urethra that obstruct the flow of urine. It most commonly presents in infancy with failure to pass urine and is diagnosed using imaging like ultrasound and voiding cystourethrography. Treatment involves surgical ablation of the valves via cystoscopy to restore urinary flow and halt renal damage. Prognosis depends on factors like age at diagnosis and degree of renal dysfunction, as patients may develop lifelong complications due to the original renal insults.
Meconium ileus is a neonatal intestinal obstruction caused by thickened meconium within the bowel lumen. It occurs in approximately 20% of cystic fibrosis patients and risk factors include a family history of cystic fibrosis or meconium ileus, as well as low birth weight. Thickened meconium leads to obstruction in the bowel, dilation of the proximal ileum, and narrowing of the distal intestine. Symptoms include failure to pass meconium and abdominal distension. Treatment options include non-operative hyperosmolar enemas to break down the thickened meconium or operative resection with enterostomy or primary anastomosis for complicated cases.
This document discusses bladder outlet obstruction (BOO) and its causes such as benign prostatic hyperplasia (BPH). It describes the primary and long term effects of BOO on the bladder, including decreased urinary flow rates and increased voiding pressures. For BPH, it notes the causes include hyperplasia of the prostate gland that typically begins in the third decade. The document outlines the diagnosis, evaluation and treatment of BOO, including medical management with medications like alpha blockers and 5-alpha reductase inhibitors, as well as surgical treatments like transurethral resection of the prostate (TURP).
Hydronephrosis is the dilation of the renal pelvis and calyces caused by obstruction of urine flow from the kidney. It can be caused by issues in the ureter, bladder, or urethra that limit urine outflow. Unilateral hydronephrosis may cause dull flank pain while bilateral obstruction can lead to decreased urine output. Left untreated, hydronephrosis can damage kidney tissue and impair renal function. Diagnosis is made through imaging tests like intravenous pyelogram. Treatment focuses on resolving the underlying cause of obstruction.
Priapism is a prolonged, unwanted erection that continues hours beyond sexual stimulation. There are two main types: ischemic (low-flow) priapism which is painful and involves little blood flow out of the penis, and non-ischemic (high-flow) priapism which is painless and involves an abnormal connection allowing high arterial inflow. Ischemic priapism is a medical emergency requiring aspiration of blood from the penis and injection of medications to induce detumescence within 4-6 hours to prevent permanent erectile dysfunction. Treatment options depend on duration and include aspiration, intracavernosal injections of medications, or surgical shunting if conservative measures fail.
Antenatally detected hydronephrosis is one of the most common abnormalities detected on prenatal ultrasound. It can identify urinary tract obstructions and reflux before complications develop. The degree of hydronephrosis seen on prenatal ultrasound provides prognostic information, with mild cases often resolving and severe cases more likely to require postnatal intervention. Evaluation after birth depends on the severity and laterality of the hydronephrosis seen prenatally, with more severe or bilateral cases warranting earlier and more extensive testing like dynamic renal scintigraphy to assess kidney function and guide management.
Hydronephrosis is the dilation of the renal pelvis and calyces, which can be caused by obstruction of urine flow. It is commonly detected during prenatal ultrasound screening. Common causes in neonates include ureteropelvic junction obstruction, posterior urethral valves, and vesicoureteral reflux. Treatment depends on the severity and includes antibiotics, surgery to repair obstructions, and management of any associated renal issues.
1) Hydronephrosis is defined as the dilatation of the pelvi-calyceal system of the kidney due to partial or intermittent blockage of urine flow.
2) Causes include congenital abnormalities, kidney stones, ureteral strictures, or compression from other structures.
3) Treatment depends on the underlying cause and includes procedures to remove obstructions like stones, repair strictures, or decompress the system with nephrostomy tubes. Surgery may be needed for severe hydronephrosis to prevent kidney damage.
Hydronephrosis is the dilatation of the renal pelvis or calyces, which can be associated with obstruction. It can be unilateral or bilateral. Unilateral causes include extramural obstruction from aberrant vessels or tumors, intramural obstruction from congenital abnormalities or strictures, and intraluminal obstruction from stones. Bilateral causes are usually congenital such as valves or acquired such as prostate enlargement. Hydronephrosis is classified based on unilateral vs bilateral involvement, intermittent vs persistent, presence of hydroureter, and location within or outside the kidney.
Hydronephrosis is dilation of the renal pelvis and calyces caused by obstruction of urine flow. It can be caused by intrinsic or extrinsic lesions and may be unilateral or bilateral. Chronic or incomplete obstruction can lead to cortical tubular atrophy, interstitial fibrosis, and thinning of the renal parenchyma over time. Acute obstruction may cause pain, while chronic or partial obstruction may have few symptoms until late stages with impaired urine concentration and renal function decline. Complete bilateral obstruction results in oliguria/anuria and requires relief of obstruction to survive.
Hydronephrosis is the dilatation of the renal pelvis and calyces caused by obstruction of urine flow from the kidney. It can be caused by congenital abnormalities, such as ureteral atresia, or acquired issues like kidney stones. On imaging, the kidney appears enlarged with a distended pelvis and thinning of the renal parenchyma. Treatment depends on the severity and cause of obstruction, ranging from nephrostomy or pyeloplasty for mild hydronephrosis to nephrectomy if the kidney is non-functioning.
Revised guidelines for management of antenatal hydronephrosis feb 2013mandar haval
This document revises guidelines from 2000 on the management of antenatally detected hydronephrosis (ANH). It recommends grading ANH based on renal pelvic diameter measured on ultrasound. For unilateral ANH, it recommends at least one follow up ultrasound in the third trimester. For bilateral ANH, it suggests frequent monitoring depending on severity. It also recommends evaluating for other anomalies and referring high-risk cases. Postnatally, it recommends ultrasound and further testing for those with diameters over 10mm or Society of Fetal Urology grade 3-4 to screen for issues like reflux or obstruction. It provides guidance on treatments like antibiotics or surgery depending on the condition. The guidelines aim to distinguish cases needing long
This document describes the case of a 4-day old male neonate admitted to the hospital for evaluation of antenatally detected bilateral hydronephrosis. The baby was delivered full-term via normal vaginal delivery and initial examinations were normal. Antenatal ultrasounds showed progressively worsening bilateral hydronephrosis. Postnatal ultrasound confirmed bilateral hydronephrosis more severe on the left side. Laboratory tests and renal function were normal. A micturating cystourethrogram detected bilateral vesicoureteral reflux grade 3 on the right and grade 2 on the left. The baby received antibiotics and was discharged with instructions to follow-up in one month and continue prophylactic medications.
1. Antenatal hydronephrosis is a common prenatal finding that requires postnatal evaluation to identify potential kidney abnormalities.
2. Most cases of antenatal hydronephrosis are transient and resolve without intervention, while others may indicate issues like urinary tract obstruction that require treatment.
3. Postnatal evaluation includes ultrasound, voiding cystourethrogram, diuretic renography and other tests to determine the severity and cause of hydronephrosis and assess kidney function.
"Understanding And Treating Major Urological Problems In Children" by Dr. Vivek Rege at HELP
This is part of the HELP Talk series at HELP,Health Education Library for People, the worlds largest free patient education library www.healthlibrary.com.
For info log on to www.healthlibrary.com.
Hydronephrosis is a condition where the kidneys become swollen due to a blockage that prevents urine from exiting properly. It is typically caused by kidney stones, tumors, or narrowing of the ureters. Common symptoms include flank pain, nausea, frequent urination, and fever with infection. Treatment aims to drain urine from the kidneys to relieve pressure and remove the underlying cause of blockage, often through procedures to insert stents or bypass the obstruction site. Without treatment, hydronephrosis can lead to permanent kidney damage or failure.
La nefrocalcinosis es una enfermedad renal que consiste en la formación de depósitos de calcio y oxalato o fosfato en los túbulos renales e intersticios, lo que puede provocar una reducción en la función renal. Se clasifica en tres grupos: hipercalciuria normocalcémica, hipercalciuria hipercalcémica y normocalciuria normocalcémica. La acidosis tubular renal distal, el síndrome de Bartter y la hiperprostaglandinemia E son causas de la hipercalciuria normocalcémica, m
The document discusses prenatal diagnosis of congenital uropathies. It defines congenital anomalies of the kidney and urinary tract (CAKUT) and notes they can be identified prenatally in ultrasound scans starting at 12 weeks gestation. The goal of prenatal consultation is to diagnose CAKUT, predict prognosis for pregnancy and child, and determine indications for termination of pregnancy, fetal surgery, or delivery. Standard prenatal exams can provide useful information but have limitations in predicting postnatal renal outcome, and advanced imaging techniques are being studied to improve prognosis.
Priapism is a persistent erection not caused by sexual stimulation that lasts over 6 hours. It is classified as low-flow or high-flow. Low-flow priapism is more common and painful due to tissue ischemia. Causes include medications, sickle cell disease, and trauma. Treatment involves aspiration of blood from the corpora followed by injection of medications to restore blood flow. If unsuccessful, surgical shunting procedures may be required to prevent erectile dysfunction. High-flow priapism is less common and usually painless due to direct arterial inflow. Treatment involves embolization of arteries to resolve the erection. Untreated low-flow priapism can lead to permanent erectile dysfunction.
The document discusses priapism, beginning with definitions and epidemiology. It then covers etiology, natural history, pathology, pathophysiology, classification, diagnosis, treatment, and complications of priapism. The key points are that priapism can be ischemic (low flow) or nonischemic (high flow) and treatment involves relieving the ischemia through aspiration or shunting for ischemic priapism or selective arterial embolization for nonischemic priapism.
Sometimes during pregnancy, there may be swelling of the kidneys called HYDRONEPHROSIS. Which can sometimes leads to complications in the mother and fetus. Contact female urology DOCTOR in Hyderabad to get best treatment, without effecting your baby’s growth.
The ureters are tubular structures that transport urine from the kidneys to the bladder. They have multiple layers including epithelium, smooth muscle, and adventitia. Sites of natural narrowing include the ureteropelvic junction (UPJ) and ureterovesical junction. UPJ obstruction is most common in boys and on the left side. It can be caused by intrinsic narrowing at the UPJ or extrinsic compression. Surgical intervention is considered if renal function declines or symptoms develop. Treatment options include open or laparoscopic pyeloplasty, endopyelotomy, or ureterocalycostomy depending on the specifics of each case.
UPJ obstruction is most commonly caused by intrinsic stenosis of the proximal ureter. It occurs in approximately 1 in 500 live births, with males and left kidneys more commonly affected. Ultrasound is used to diagnose and monitor hydronephrosis, while diuretic renography can determine if obstruction is present and assess renal function. Surgical correction via pyeloplasty is indicated if renal function is impaired or decreasing, with the Anderson-Hynes dismembered pyeloplasty being the most common procedure performed. Non-operative management with antibiotics may be appropriate if drainage is adequate on functional studies.
Neuroblastoma is the third most common childhood cancer and arises from sympathetic nervous system. Staging involves evaluating tumor size, spread and biomarkers. Treatment ranges from observation to intensive chemotherapy and stem cell transplant depending on risk factors like age, stage, genetics and response to initial treatment. Targeted therapies are being studied in recurrent and high risk disease.
This document discusses the management of fetal hydronephrosis. It begins by defining hydronephrosis as the dilatation of the renal pelvis with or without calyceal dilatation. It then covers the grading of fetal hydronephrosis based on gestational age and renal pelvic diameter. Risk stratification systems like the UTD system are presented. Management depends on factors like severity, laterality, and presence of other anomalies. Most cases resolve spontaneously but severe or progressive cases may require interventions like pyeloplasty.
Management of pelviureteric junction obstruction onyeze copyChigozie Onyeze
This document provides an outline and overview of pelviureteric junction obstruction. It discusses the epidemiology, relevant anatomy, etiology, pathophysiology, clinical features, investigations, and management including surgical and non-surgical treatment options. The standard surgical procedure for repair is the Anderson-Hynes dismembered pyeloplasty technique, which involves excision of the narrowed segment and anastomosis of the renal pelvis to the ureter. Other approaches include endoscopic techniques, laparoscopic pyeloplasty, and robotic-assisted surgery. Proper pre-operative evaluation and post-operative care are important for optimal outcomes.
PUJO is an obstruction of the proximal ureter at the junction with the renal pelvis. It is most common in childhood, affecting 1 in 1000 children, with boys more commonly affected than girls. Presentation includes flank pain, flank mass, nausea, vomiting, recurrent UTIs, and hematuria. Diagnosis involves blood tests, urine tests, ultrasounds, CT scans, nuclear scans, and retrograde pyelography. Treatment depends on symptoms and impairment - watchful waiting may be sufficient, but surgery like pyeloplasty is often needed and has a high success rate of 90-95%.
This document discusses obstructive uropathy in neonates. It begins with an example case of a preterm baby with bilateral hydronephrosis and thickened bladder walls. It then provides general information on obstructive uropathy including causes, presentations, investigations, and treatment principles. Specific conditions discussed in more detail include posterior urethral valves, ureteropelvic junction obstruction, and vesicoureteric reflux.
PUJ obstruction is a restriction of urine flow from the renal pelvis to the ureter. It can be congenital or acquired, with congenital being one of the most common causes of antenatal hydronephrosis. Diagnosis involves ultrasonography, VCUG, diuretic renography and other imaging modalities to determine severity and presence of associated issues. Treatment depends on severity but typically involves surgical intervention like open or laparoscopic pyeloplasty to resect and reanastomose the obstructed segment if drainage is significantly impaired or renal growth is poor. Postoperative follow up with imaging is important to monitor repair.
posterior urethral valve.. ahmed oshibaahmed eshiba
This document discusses posterior urethral valves, a congenital abnormality affecting male newborns. It presents in about 1 in 5000 live male births and causes obstructive uropathy. Symptoms range from asymptomatic to renal failure and can include urinary retention, infection, distension. Antenatal diagnosis is now common using ultrasonography showing keyhole sign and hydronephrosis. Initial management involves catheterization and antibiotics with endoscopic valve ablation usually within days of birth. Long term risks include bladder dysfunction, reflux, hypertension and end stage renal disease in approximately 25% of cases. Close follow up is needed to monitor renal function and treat complications.
This document provides an overview of the approach to congenital hydronephrosis. It defines hydronephrosis and describes the most common causes including physiologic hydronephrosis, UPJ obstruction, UVJ obstruction, VUR, Eagle-Barrett Syndrome, PUV, and MCDK. It discusses grading of fetal and neonatal hydronephrosis using RPD, SFU criteria, and UTD classification system. The document outlines the approach including physical exam, imaging studies like VCUG and diuretic renography to diagnose underlying causes and guide treatment.
This document discusses obstructive uropathy in neonates. It presents a case of a preterm baby with bilateral hydronephrosis and a thick bladder wall. Key points discussed include the causes, presentations, investigations, and management of obstructive uropathy. Posterior urethral valves and ureteropelvic junction obstruction are examined in more detail. Vesicoureteric reflux is also summarized. The document emphasizes relieving obstruction, treating infection, and sorting the primary cause in managing obstructive uropathy.
The document discusses radiological approaches to diagnosing and evaluating urinary tract infections (UTIs). It begins by distinguishing between upper and lower UTIs, as well as uncomplicated and complicated UTIs. Common causative organisms of UTIs are also identified. Various imaging modalities are then described for evaluating UTIs, including intravenous urography, ultrasound, CT, MRI, and nuclear medicine scans. Specific radiological findings of acute bacterial pyelonephritis, chronic pyelonephritis, tuberculous infections of the urinary tract are also summarized.
This document provides an overview of esophageal atresia and tracheoesophageal fistula. It defines the conditions, discusses their embryology and causes. It also covers classification, associated anomalies, pathophysiology, diagnosis, investigations, management including surgical correction, complications and prognosis. The key points are that esophageal atresia is a congenital discontinuity of the esophageal lumen, it can occur with or without a tracheoesophageal fistula, and immediate surgical repair is typically required to reconnect the esophagus and prevent aspiration.
The document discusses the kidney, ureter, and various urological conditions involving obstruction of urine flow from the kidneys to the bladder such as hydronephrosis and pyonephrosis. It describes the anatomy and function of the kidneys and ureters. Causes of urinary obstruction include kidney stones, tumors, strictures, and congenital abnormalities. Patients present with flank pain, urinary tract infections, and renal impairment depending on severity and chronicity of obstruction. Investigations include ultrasound, IVU, CT urogram and MAG-3 scans. Management involves relieving obstruction through stenting, nephrostomy or surgery.
With easy availability of ultrasound screening and improvement in expertise, hydronephrosis is now a very frequently diagnosed problem reported in 1 to 5% of all pregnancies. This has enabled us to have a better understanding of the natural course of the problem and early intervention before it results in permanent renal damage.
Obstructive uropathy refers to any obstruction in the urinary tract. It can cause changes including hydronephrosis (distension of the kidneys and ureters) and hydroureteronephrosis (distension of the kidneys, ureters and bladder). The document discusses the classification, causes, pathology, investigations and management of various types of obstructive uropathy including ureteric strictures and retroperitoneal fibrosis. Surgical intervention is often needed to relieve the obstruction and treat associated complications.
This document discusses urinary incontinence and provides information on various related topics. It defines urinary incontinence and discusses its epidemiology and various causes. The causes of urinary stress incontinence are explained. Diagnosis and investigations for stress incontinence are outlined, including pelvic exams, postvoid residual measurement, and urodynamic studies. Conservative and surgical management options for stress incontinence are summarized. Overactive bladder is also defined.
the mesonephric duct and embryology of ureter .pptvenkateshendr
At the end of the fourth week of embryonic life, the mesonephric duct develops a localized thickening that gives rise to the ureteric bud. The ureteric bud is a simple epithelial tube that grows cranially to meet the metanephric cap
CT plays an important role in imaging urosepsis and urinary tract infections. It can confirm or change diagnoses in 33-59% of cases and change treatment in 28-42% of cases. CT is useful for detecting infection foci when clinical infection is obscure. It can identify various urinary tract conditions like pyelonephritis, renal and perinephric abscesses, xanthogranulomatous pyelonephritis, and tuberculosis. Findings include renal enlargement, parenchymal defects, nephromegaly, perinephric stranding, and calcifications. CT accurately depicts the extent of infection and guides appropriate management.
This document discusses ionizing radiation, its biological effects, and safety issues. It begins by defining ionizing radiation and its units of measurement. It then describes the mechanisms by which ionizing radiation can damage cells, particularly DNA, and potentially lead to genetic mutations and cancer initiation. Key factors that influence radiosensitivity, such as the cell cycle phase and tissue type, are also covered. The document discusses deterministic effects, which occur above threshold doses, and stochastic effects like cancer that occur probabilistically. Guidelines for radiation protection emphasize justification of exposures and optimizing procedures to minimize risks.
Pediatric urinary tract infection..the role of imagingAhmed Bahnassy
Urinary tract infections are common in children and imaging plays an important role. Ultrasound can be used to (1) identify potential causes of infection, (2) determine if kidneys are normal or at risk for scarring, and (3) detect issues like reflux that facilitate infection. The document outlines ultrasound techniques for evaluating the urinary bladder, kidneys, and ureters in children with UTIs and describes findings of conditions like acute pyelonephritis, abscesses, and scarring. Ultrasound remains valuable for characterizing urinary tract anatomy and complications in pediatric UTI patients.
This document discusses how to report findings from HRCT scans of the lungs in patients with interstitial lung disease. It begins by describing the scanning technique and basic lung anatomy. It then outlines a systematic approach to interpretation, including recognizing patterns (reticular, nodular, increased/decreased opacity), locating abnormalities, and evaluating effects on lung parenchyma. Specific disease patterns and findings are discussed along with their typical causes. Golden rules for interpretation are provided. References for further reading are included.
This document discusses the use of ultrasound in critically ill patients. It aims to explain how ultrasound can guide management of hemodynamically unstable patients by rapidly evaluating for reversible causes of shock. The RUSH (Rapid Ultrasound in Shock) protocol is described, which involves using ultrasound to examine the heart (the pump), assess intravascular volume status (the tank), and check for issues with blood vessels (the pipes). Common pathologies that can be identified include cardiac tamponade, pulmonary embolism, hemorrhage, aortic dissection, and thrombosis. Examples of abdominal ultrasound findings in critical illnesses such as gangrenous cholecystitis, emphysematous cholecystitis, liver abscess
This document discusses the essential role of Doppler ultrasound in evaluating the kidneys and renal vasculature. It highlights how Doppler can be used to assess renal transplants, plan for dialysis access procedures, and monitor access complications. Specific applications covered include evaluating for renal artery stenosis, aneurysms, masses, fistulas and grafts. Assessment criteria and normal versus abnormal Doppler findings are presented for many common renal and vascular conditions.
This document provides information on performing and interpreting renal Doppler ultrasounds. It discusses the optimal approaches for imaging the renal arteries, including the anterior, oblique, and flank approaches. It also outlines criteria for evaluating renal artery stenosis, including peak systolic velocity measurements and the renal-aortic ratio. Common renal pathologies that can be identified with Doppler ultrasound are also summarized, such as fibromuscular dysplasia, atherosclerosis, aneurysms, and hydronephrosis.
This document provides an overview of performing lower limb doppler examinations to diagnose deep vein thrombosis and other causes of limb pain. It discusses the essential techniques including recognizing the vessels, avoiding pitfalls, applying compression, and following the anatomy. Criteria for diagnosing DVT include vessel expansion, compressibility, presence of thrombus, and absent or reduced blood flow waves. The document also reviews using doppler to diagnose and grade arterial stenosis by analyzing spectral wave patterns and meanings.
This document provides an overview of the techniques and findings for abdominal and pelvic ultrasound examination. It outlines a systematic approach to scanning the major abdominal organs and structures, including the aorta, inferior vena cava, liver, gallbladder, pancreas, spleen, kidneys, and bladder. For each area, normal anatomy and measurements are defined, and common pathological findings are described with examples of ultrasound appearances. The goal is to perform a comprehensive exam in a timely manner while avoiding misses or errors.
This document provides an overview of neonatal brain anatomy and common pathologies seen on ultrasound. It begins with a review of embryonic brain development and the anatomy of structures like the ventricles, basal ganglia, cerebellum and vascular system. Common indications for neonatal brain ultrasound are described. The technique involves scanning standardized coronal and sagittal views to evaluate the supratentorial and infratentorial compartments. Common abnormalities like Chiari malformation, holoprosencephaly, Dandy-Walker malformation, agenesis of the corpus callosum, ventriculomegaly and hydrocephalus are summarized with their characteristic ultrasound findings. Hemorrhagic pathologies such as intraventricular and
Unresolved pulmonary infections can be due to various causes including virulent organisms, underlying diseases, or complications. Radiology plays an important role in evaluating infections by diagnosing the location and etiology of infections, following treatment response, and monitoring complications. It is important to consider various infectious organisms, routes of infection, underlying conditions, and non-infectious potential causes of pulmonary opacities when evaluating patients with unresolved pulmonary issues.
Approach to right upper quadrant pain-lessons from a caseAhmed Bahnassy
This document discusses a case of right upper quadrant abdominal pain. Imaging including ultrasound, CT, and MRI found irregular gallbladder wall thickening, gallstones, and increased signal surrounding the gallbladder. Pathology after cholecystectomy found xanthogranulomatous cholecystitis, a rare form of chronic cholecystitis characterized by a thickened fibrotic gallbladder wall with foamy histiocytes and bile extravasation. A final diagnosis of xanthogranulomatous cholecystitis was made based on gross and histologic findings.
This document discusses the use of ultrasound in evaluating various abdominal emergencies. It outlines that ultrasound is well-suited for the acute abdomen as it is noninvasive, portable, and lacks radiation. Key points include:
- Ultrasound can reliably diagnose acute cholecystitis by identifying gallstones and a positive Murphy's sign. It can also detect complications and non-biliary causes of right upper quadrant pain.
- Ultrasound effectively identifies choledocholithiasis through various imaging planes. It also evaluates other potential causes of pain like liver abscesses, masses, pancreatitis, and renal or vascular issues.
- Common ultrasound findings are discussed for many acute surgical and medical conditions of the
Squeezed through holes: imaging of internal herniaAhmed Bahnassy
This document discusses internal hernias, which occur when abdominal organs protrude through openings within the abdominal cavity. It describes several types of internal hernias, including paraduodenal, foramen of Winslow, intersigmoid, pericecal, transmesenteric, and retroanastomotic hernias. For each type, it provides details on location, risk factors, and radiographic findings such as clustering of bowel loops and abnormalities of mesenteric vessels. The document emphasizes the importance of recognizing abnormal bowel positioning and configurations, signs of obstruction, and vessel abnormalities on imaging studies to diagnose internal hernias.
Ionizing radiation hazards and safety :must knowAhmed Bahnassy
This document discusses ionizing radiation, its biological effects, and safety issues. It begins by outlining the aims of discussing the mechanisms and effects of ionizing radiation exposure, associated risks, and main safety protections. Ionizing radiation is then defined as radiation that can ionize atoms and is capable of breaking chemical bonds. Sources of ionizing radiation and its units of measurement are also outlined. The document goes on to explain how ionizing radiation can damage DNA through direct interactions or free radicals produced from radiolysis of water. This damage can lead to mutations, chromosome aberrations, cell death or cancer initiation through multiple stages. Radiobiologists assume not all DNA damage is repaired.
Vasculitis is a condition characterized by inflammation and damage to blood vessels. There are several types of vasculitis classified by the size of vessels affected (large, medium, small). Imaging plays an important role in the diagnosis and monitoring of vasculitis by detecting vessel wall abnormalities and inflammation before lumen changes occur on angiography. Techniques like CT angiography, MRI, MRA, and PET are useful for revealing vessel wall alterations and inflammation. The choice of imaging depends on the suspected organ involvement.
This document provides a detailed overview of neonatal brain anatomy and ultrasound techniques. It begins with a review of embryonic development and the formation of the primary brain vesicles. Next, it describes the anatomy of various brain structures including the cerebrum, ventricles, meninges, cerebrovascular system, and skull fontanelles. Indications for neonatal brain ultrasound are outlined. The technique section explains the transducer usage and standard imaging planes. Common pathologies seen in neonatal brain ultrasound such as holoprosencephaly, Dandy-Walker malformation, and hydrocephalus are described. In summary, this document serves as a comprehensive reference for neonatal brain anatomy and ultrasound.
It describes regarding the diagnostic studies in gastrointestinal tract. It gives a detailed information on the investigations needed to diagnose a disease in git.
Pathophysiology of obesity - Rawa MuhsinRawa Muhsin
This is my presentation about the pathophysiology of obesity, including its genetic causes, environmental/acquired factors, and the underlying mechanisms leading to the complications of obesity.
Learning Objectives:
1. Discuss the processing of T & B lymphocytes in human body
2. Give a brief account on lymphocyte cloning
3. Comprehend the concept of humoral immunity
4. Discuss the structure of antibodies
5. Classify antibodies and discuss their functions
6. Explain the role of antibodies in B-cell immunity
7. Discuss the direct and indirect actions of antibodies
MSUS musculoskeletal ultrasound On The wrist
basic level
Marwa Abo ELmaaty Besar
Lecturer of Internal Medicine
(Rheumatology Immunology unit)
Faculty of medicine
Mansoura University
Formulation and evaluation of Poly herbal face syrum..VishalGautam960592
Formulation and evaluation of Poly herbal face syrum by using pomegranate and curcumine.various parameters are evaluated and found to ba a good result.
Absolute: Surgery is required to save life or prevent serious harm (e.g., perforated appendix).
Relative: Surgery is beneficial but not immediately necessary (e.g., elective hernia repair).
Diagnostic: When a definitive diagnosis cannot be made without surgical exploration (e.g., diagnostic laparoscopy).
Chosen based on anatomical landmarks, underlying pathology, and surgical approach.
Made with precision to minimize bleeding, injury to nearby structures, and scarring.
Closed with sutures, staples, or surgical glue after the procedure.
By: Dr Aliya Shair MUhammad PT
DPT OMPT
Lecturer: Bolan University Of Medical and Health Sciences ,Quetta
Chair, Angela Hirbe, MD, PhD, discusses NF1 in this CME/AAPA/IPCE activity titled “Bridging Gaps, Shaping Lifelong NF1 Care: Team Strategies & Management Choices With MEK Inhibitors Across the Pediatric-to-Adult Care Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/4hn0sUq. CME/AAPA/IPCE credit will be available until May 5, 2026.
Veterinary Pharmacology and Toxicology Notes for Diploma StudentsSir. Stymass Kasty
This covers the wide range of Pharmacology and Toxicology on the basis of Drug and Toxicants identification, Pharmacotherapy and Management of Toxicosis in Animals
Dimethylaniline: Physical & Chemical Properties, Synthesis Methods, and Pharm...jhakasayushgautam
Explore the essential chemistry of Dimethylaniline, including its physical and chemical properties, general synthesis methods, and pharmaceutical applications. This presentation is perfect for chemistry students, educators, and professionals looking to deepen their understanding of this important aromatic amine. Learn how dimethylaniline is used in drug formulation and discover its relevance in organic chemistry labs.
Analgesia system & Abnormalities of Pain_AntiCopy.pdfMedicoseAcademics
This comprehensive lecture by Dr. Faiza (MBBS – Best Graduate, AIMC Lahore | FCPS Physiology | ICMT, CHPE, DHPE – STMU | MPH – GC University Faisalabad | MBA – Virtual University of Pakistan) provides an expert-level overview of the central analgesia system, pain modulation mechanisms, and various clinical abnormalities of pain.
Designed for undergraduate and postgraduate medical learners, this session integrates neurophysiology, pharmacology, and clinical neurology to explain how the body perceives, modulates, and at times misinterprets pain.
🧠 Key Learning Objectives:
Understand the central pain modulation system and its neural architecture.
Explore the role of endogenous and exogenous opioids in analgesia.
Analyze the physiological basis of non-pharmacological pain relief (massage, acupuncture, liniments, electrical stimulation).
Enumerate and explain abnormal pain conditions such as hyperalgesia, allodynia, shingles, trigeminal neuralgia, and different types of headaches.
Interpret the pathophysiology of migraines including vascular and cortical spreading depression theories.
🔬 Lecture Highlights:
✅ Central Analgesia System:
Neural pathways: Periaqueductal gray, Raphe magnus nucleus, spinal dorsal horn
Neurochemicals involved: Enkephalins, Serotonin
Gate Control Theory: Tactile input via Aβ fibers inhibits pain transmission
✅ Pain Suppression Mechanisms:
Massage & Rubbing: Local tactile inhibition via Aβ fibers
Acupuncture & Liniments: Dual role in stimulating pain gating and central analgesia
Electrical Stimulation: From surface electrodes to stereotactic thalamic implants
Patient-controlled neuromodulation: Tailoring stimulation for chronic pain
✅ Abnormalities of Pain:
Hyperalgesia: Heightened sensitivity to painful stimuli (primary and secondary)
Allodynia: Pain perception from non-painful stimuli
Herpes Zoster: Segmental dermatomal pain from dorsal root ganglion infection
Tic Douloureux: Trigeminal neuralgia characterized by sudden, stabbing facial pain
✅ Headache Pathophysiology:
Intracranial: Meningitis, low CSF pressure, migraines, alcohol
Extracranial: Muscle spasm, sinusitis, eye strain, light exposure
Migraine Mechanisms: Vascular spasm, cortical depression, serotonin imbalance, and familial genetics
✅ Clinical Correlation:
Brown-Séquard Syndrome: Sensory and motor dissociation explained by hemisection
Central vs. Peripheral Lesions in pain disorders
👨⚕️ Ideal for:
MBBS, BDS, and Allied Health Students
FCPS/MD/MS Physiology Trainees
Residents in Neurology, Anesthesia, and Internal Medicine
Physiology educators and academic examiners
Candidates preparing for USMLE, PLAB, FCPS, MDCAT, or Step 1
Presented by:
Dr. Faiza
Assistant Professor of Physiology
FCPS Physiology | CHPE | DHPE | MPH | MBA
Allama Iqbal Medical College (Best Graduate)
TH'e Oncology Meds delivers cutting-edge, patient-focused cancer treatments with precision and care. Our innovative therapies are designed to target cancer at its core, improving outcomes and enhancing quality of life. We combine advanced research with compassionate support to empower patients through every stage of their oncology journey.
This presentation provides a concise overview of Smith-Lemli-Optiz Syndrome (SLOS), a rare autosomal recessive metabolic disorder caused by mutations in the DHCR7 gene, affecting Cholesterol biosysnthesis. It covers clinical features, diagnostic approaches and treatment options. Suitable for medical students, genetics professionals and anyone interested in rare genetic disorders.
2. Importance of the finding
• Most common congenital condition
discovered by antenatal US.
• ultrasonography enables us to detect the
correctable cause of hydronephrosis, such
as ureteropelvic junction obstruction.
• Failure of recognizing those needing
surgical intervention will result in
permanent loss of the kidney.
3. Fetal hydronephrosis Detection
• Grignon et al developed a grading system for hydronephrosis in
fetuses of 20 weeks gestation or greater in relation to their postnatal
findings.
• Grade I dilatations (AP renal pelvic diameter up to 1.0 cm) were
described as normal and physiologic because none of the affected
patients required surgery after birth.
• Grade II (>1.0–1.5 cm) and grade III (>1.5 cm with slight dilatation of
calices) dilatation was termed intermediate hydronephrosis; 50%
required postnatal surgical intervention.
• All patients with grade IV dilatation (>1.5-cm pelvis, moderate
dilatation of calices, no cortical atrophy) or grade V hydronephrosis
(>1.5-cm pelvis, severe caliceal dilatation, atrophic renal cortex)
required surgery.
• Their work suggests that one should be concerned with pelvic
dilatations greater than 10 mm particularly if there is associated
calyceal dilatation and loss of cortex.
4. • Clinically significant disease is more likely
if:
• (1) a grade 3 or 4 hydronephrosis is
present;
• (2) the renal pelvis diameter is > 10 mm;
• (3) the renal pelvis/kidney ratio is > 0.5.
5. Incidence:
• Pre-natal ultrasound
– detects fetal anomaly in 1% of
pregnancies, of which 20-30%
are genitourinary in origin and
50% manifest as hydronephrosis
6. Grading of Severity of
Hydronephrosis
Grade Central Renal Renal
Complex Parenchymal
Thickness
0 Intact Normal
1 Slight splitting Normal
2 Evident splitting Normal
3 Wide splitting Normal
4 Further dilatation Thin
7. Pathophysiology:
• Anatomic and functional processes
interrupts the flow of urine.
• There is a rise in ureteral pressure
causing stretching and dilation; if
pressures continue to rise, leads to
decline in renal blood flow and GFR.
• When significant obstruction is
persistent, it affects nephrogenic tissue
and results in varying degrees of cystic
dysplasia and renal impairment.
11. I-Mild (Grade II)
• These images shows mild dilatation of the pelvis as well
as the calyces of the right kidney
12. II-Moderate (III)
• The above ultrasound images show cupping of the calyces with moderate dilation
(Right kidney) of the pelvis and calyces. Despite the hydronephrosis the renal
parenchyma is still preserved.
13. III-severe (IV)
• The above sonographic images show marked dilatation of the
pelvicalyces with sever thinning of the renal parenchyma. note
almost total absence of normal renal tissue (cortex).