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Smart Health for Patient Safety & Quality
นพ.นวนรรน ธีระอัมพรพันธุ์
17 ธ.ค. 2562
www.SlideShare.net/Nawanan
What words come to mind when you hear...
Digital Health
Transformation
https://medium.com/@marwantarek/it-is-the-perfect-storm-ai-cloud-bots-iot-etc-4b7cbb0481bc
http://www.ibtimes.com/google-deepminds-alphago-program-defeats-human-go-champion-first-time-ever-2283700
http://deepmind.com/ http://socialmediab2b.com
An Era of Smart Machines
englishmoviez.com
Rise of the Machines?
Digitizing Healthcare?
http://www.bloomberg.com/bw/stories/2005-03-27/cover-image-the-digital-hospital
“Big data is like teenage sex:
everyone talks about it,
nobody really knows how to do it,
everyone thinks everyone else is doing it,
so everyone claims they are doing it...”
-- Dan Ariely @danariely (2013)
Substitute “Big data” with “AI”, “Blockchain”, “IoT”
of your choice.
-- Nawanan Theera-Ampornpunt (2018)
Hype vs. Hope
Jeremy Kemp via http://en.wikipedia.org/wiki/Hype_cycle
http://www.gartner.com/technology/research/methodologies/hype-cycle.jsp
Gartner Hype Cycle 2017
https://www.gartner.com/smarterwithgartner/top-trends-in-the-gartner-hype-cycle-for-emerging-technologies-2017/
“Smart” Machines?
https://www.bbc.com/news/business-47514289
https://www.standardmedia
.co.ke/article/2001318679/e
thiopian-airlines-crash-
investigators-reach-
conclusion
A Real-Life Personal Story of
My Failure (as a Doctor and as
a Son) in Misdiagnosing
My Mom
Would AI Help?
• Nothing is certain in medicine &
health care
• Large variations exist in patient
presentations, clinical course,
underlying genetic codes, patient &
provider behaviors, biological
responses & social contexts
Why Clinical Judgment Is Still Necessary?
• Most diseases are not diagnosed by
diagnostic criteria, but by patterns of
clinical presentation and perceived
likelihood of different diseases given
available information (differential
diagnoses)
• Human is good at pattern
recognition, while machine is good at
logic & computations
Why Clinical Judgment Is Still Necessary?
• Machines are (at best) as good as
the input data
–Not everything can be digitized or
digitally acquired
–Not everything digitized is accurate
(“Garbage In, Garbage Out”)
• Experience, context & human touch
matters
Why Clinical Judgment Is Still Necessary?
Health &
Health Information
“To computerize
the hospital”
“To go paperless”
“To become a
Digital Hospital”
“To Have
EHRs”
Why Adopting Health IT?
• “Don’t implement technology just for
technology’s sake.”
• “Don’t make use of excellent technology.
Make excellent use of technology.”
(Tangwongsan, Supachai. Personal communication, 2005.)
• “Health care IT is not a panacea for all that ails
medicine.” (Hersh, 2004)
Some “Smart” Quotes
Digitization 
Digital Transformation
Being Smart #1:
Stop Your
“Drooling Reflex”!!
Being Smart #2:
Focus on Information &
Process Improvement,
Not Technology
If not “Digital Hospital”
or “Paperless Hospital”
Then What Should We
Aspire to Be?
“Smart Hospital”
Back to
something simple...
To treat & to care
for their patients
to their best
abilities, given
limited time &
resources
Image Source: http://en.wikipedia.org/wiki/File:Newborn_Examination_1967.jpg (Nevit Dilmen)
What Clinicians Want?
Why Aren’t We Talk About These Words?
http://hcca-act.blogspot.com/2011/07/reflections-on-patient-centred-care.html
The Goal of Health Care
The answer is already obvious...
“Health”
“Care”
• Safe
• Timely
• Effective
• Patient-Centered
• Efficient
• Equitable
Institute of Medicine, Committee on Quality of Health Care in America. Crossing the quality
chasm: a new health system for the 21st century. Washington, DC: National Academy
Press; 2001. 337 p.
High Quality Care
(IOM, 2001)(IOM, 2000) (IOM, 2011)
Landmark Institute of Medicine Reports
• Humans are not perfect and are bound to
make errors
• Highlight problems in U.S. health care
system that systematically contributes to
medical errors and poor quality
• Recommends reform
• Health IT plays a role in improving patient
safety
Summary of These Reports
30
• Perception errors
Image Source: interaction-dynamics.com
To Err Is Human 1: Perception
31
Image Source: (Left) http://docwhisperer.wordpress.com/2007/05/31/sleepy-heads/
(Right) http://graphics8.nytimes.com/images/2008/12/05/health/chen_600.jpg
To Err Is Human 2: Attention
32
Image Source: Suthan Srisangkaew, Department of Pathology, Facutly of Medicine Ramathibodi Hospital, Mahidol University
To Err Is Human 3: Memory
33
• Cognitive Errors - Example: Decoy Pricing
The Economist Purchase Options
• Economist.com subscription $59
• Print subscription $125
• Print & web subscription $125
Ariely (2008)
16
0
84
The Economist Purchase Options
• Economist.com subscription $59
• Print & web subscription $125
68
32
# of
People
# of
People
To Err Is Human 4: Cognition
34Klein JG. Five pitfalls in decisions about diagnosis and prescribing. BMJ. 2005 Apr 2;330(7494):781-3.
“Everyone makes mistakes. But our
reliance on cognitive processes prone to
bias makes treatment errors more likely
than we think”
Cognitive Biases in Healthcare
35
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
Clinical Decision Making
36
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
Possible Human Errors
Possibility of
Human Errors
37
CLINICAL DECISION
SUPPORT SYSTEMS
(CDS)
38
• Clinical Decision Support (CDS) “is a
process for enhancing health-related
decisions and actions with pertinent,
organized clinical knowledge and patient
information to improve health and healthcare
delivery” (Including both computer-based &
non-computer-based CDS)
(Osheroff et al., 2012)
What Is A CDS?
39
• The real place where most of the values
of health IT can be achieved
• There are a variety of forms and nature
of CDS
Clinical Decision Support
Systems (CDS)
40
• Expert systems
–Based on artificial
intelligence, machine
learning, rules, or
statistics
–Examples: differential
diagnoses, treatment
options
CDS Examples
Shortliffe (1976)
41
• Alerts & reminders
–Based on specified logical conditions
• Drug-allergy checks
• Drug-drug interaction checks
• Drug-lab interaction checks
• Drug-formulary checks
• Reminders for preventive services or certain actions
(e.g. smoking cessation)
• Clinical practice guideline integration (e.g. best
practices for chronic disease patients)
CDS Examples
42
Example of “Reminders”
43
• Reference information or evidence-
based knowledge sources
–Drug reference databases
–Textbooks & journals
–Online literature (e.g. PubMed)
–Tools that help users easily access
references (e.g. Infobuttons)
CDS Examples
44
Infobuttons
Image Source: https://webcis.nyp.org/webcisdocs/what-are-infobuttons.html
45
• Pre-defined documents
–Order sets, personalized “favorites”
–Templates for clinical notes
–Checklists
–Forms
• Can be either computer-based or
paper-based
CDS Examples
46
Order Sets
Image Source: http://www.hospitalmedicine.org/ResourceRoomRedesign/CSSSIS/html/06Reliable/SSI/Order.cfm
47
• Simple UI designed to help clinical
decision making
–Abnormal lab highlights
–Graphs/visualizations for lab results
–Filters & sorting functions
CDS Examples
48
Abnormal Lab Highlights
Image Source: http://geekdoctor.blogspot.com/2008/04/designing-ideal-electronic-health.html
49
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Abnormal lab
highlights
50
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Order Sets
51
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Drug-Allergy
Checks
52
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Drug-Drug
Interaction
Checks
53
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Clinical Practice
Guideline
Alerts/Reminders
54
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Integration of
Evidence-Based
Resources (e.g.
drug databases,
literature)
55
External Memory
Knowledge Data
Long Term Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Diagnostic/Treatment
Expert Systems
Being Smart #3:
“To Err is Human”
Being Smart #4:
Link IT Values to
Quality (Including Safety)
Health IT
Health
Information
Technology
Goal
Value-Add
Means
ภาพรวมของงานด้าน Health IT
Intra-Hospital IT
• Electronic Health Records &
Health IT for Quality & Safety
• Digital Transformation
• AI, Data Analytics
• Hospital IT Quality
Improvement (HA-IT)
Inter-Hospital IT
• Health Information
Exchange (HIE)
Extra-Hospital IT
• Patients: Personal
Health Records (PHRs)
• Public Health: Disease
Surveillance & Analytics
Patient
at Home
Strategic
Operational
ClinicalAdministrative
LIS
Health Information ExchangeBusiness
Intelligence
Word
Processor
Social
Media
PACS
Personal Health Records
Clinical Decision Support Systems
Computerized Physician Order Entry
Electronic Health Records
Admission-Discharge-Transfer
Master Patient Index
Enterprise Resource Planning
Vendor-Managed Inventory
Customer Relationship Management
4 Quadrants of Hospital IT
ภาพรวมของงานด้าน Health IT
Intra-Hospital IT
• Electronic Health Records &
Health IT for Quality & Safety
• Digital Transformation
• AI, Data Analytics
• Hospital IT Quality
Improvement (HA-IT)
Inter-Hospital IT
• Health Information
Exchange (HIE)
Extra-Hospital IT
• Patients: Personal
Health Records (PHRs)
• Public Health: Disease
Surveillance & Analytics
Patient
at Home
Hospital A Hospital B
Clinic D
Policymakers
Patient at
Home
Hospital C
HIE Platform
Health Information Exchange (HIE)
WHO & ITU
Achieving Health Information Exchange (HIE)
https://www.hfocus.org/content/2016/02/11783
https://www.hfocus.org/content/2016/03/11968
https://www.hfocus.org/content/2016/09/12671
Areas of Health Informatics
Patients &
Consumers
Providers &
Patients
Healthcare
Managers, Policy-
Makers, Payers,
Epidemiologists,
Researchers
Copyright  Nawanan Theera-Ampornpunt (2018)
Clinical
Informatics
Public
Health
Informatics
Consumer
Health
Informatics
Incarnations of Health IT
Clinical
Informatics
Public
Health
Informatics
Consumer
Health
Informatics
HIS/CIS
EHRs
Computerized Physician
Order Entry (CPOE)
Clinical Decision
Support Systems
(CDS) (including AI)
Closed Loop
Medication
PACS/RIS
LIS
Nursing
Apps
Disease Surveillance
(Active/Passive)
Business
Intelligence &
Dashboards
Telemedicine
Real-time Syndromic
Surveillance
mHealth for Public
Health Workers &
Volunteers
PHRs
Health Information
Exchange (HIE)
eReferral
mHealth for
Consumers
Wearable
Devices
Social
Media
Copyright  Nawanan Theera-Ampornpunt (2018)
Where We Are Today...
Copyright  Nawanan Theera-Ampornpunt (2018)
Clinical
Informatics
Public
Health
Informatics
Consumer
Health
Informatics
Technology that
focuses on the sick,
not the healthy
Silos of data
within hospitalPoor/unstructured
data quality
Lack of health data
outside hospital
Poor data
integration across
hospitals/clinics
Poor data integration
for monitoring &
evaluation
Poor data quality (GIGO)
Finance leads
clinical outcomes
Poor IT change
management
Cybersecurity
& privacy risks
Few real examples
of precision
medicine
Little access
to own
health data
Poor patient
engagement
Poor accuracy
of wearables Lack of evidence
for health values
Health literacy
Information 
Behavioral
change
Few standards
Lack of health IT
governance
• CDS as a replacement or supplement of
clinicians?
– The demise of the “Greek Oracle” model (Miller & Masarie, 1990)
The “Greek Oracle” Model
The “Fundamental Theorem” Model
Friedman (2009)
Wrong Assumption
Correct Assumption
Clinical Decision Support Systems (CDS)
Being Smart #5:
Don’t Replace
Human Users.
Use ICT to Help Them
Perform Smarter & Better.
Some Risks of Clinical Decision Support Systems
• Alert Fatigue
Unintended Consequences of Health IT
Workarounds
Unintended Consequences of Health IT
Being Smart #6:
Health IT Also Have
Risks &
Unintended Consequences
Technology
ProcessPeople
Balanced Focus of Informatics
Being Smart #7:
Balance Your Focus
(People, Process, Technology)
Envisioning a Smart Health Thailand
76
#LessHype
#MoreHope
My Plea...

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