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Peak & Trough
 Vancomycin is a glycopeptide antibiotic. It is a time
  dependent killer. The level has to stay above a minimum
  concentration for a length of time for the medication to be
  effective. Thus, Vancomycin doses should not be held while
  waiting for a trough level.
 Vancomycin peak levels are not routinely
  monitored, however if ordered by the MD, the peak should
  be drawn 1 hour after medication dose is complete.
 Exception – if the ordered dose of Vancomycin is 2 grams or
  more then obtain the peak 2 hours after the infusion is
  complete.
Peak & Trough (cont)
 Collect trough immediately prior to dose
 Blood must NOT be drawn from the line it was infusing in
 Blood is drawn from a different port, it is NOT drawn from the
  port it was infused in
 Do not draw a trough level while Vancomycin is infusing
 Do not wait for trough results before hanging antibiotic unless
  a specific order to wait for result is ordered by MD
 Administer antibiotic at prescribed rate so levels are accurate
Peak & Trough (continued)
Gentamicin
 Gentamicin is an aminoglycoside antibiotic. It works
  differently. It is a concentration dependent killer. This means
  the higher the peak concentration, the larger the kill of
  microorganisms. Gentamicin can kill microorganisms after the
  concentration has decreased (this is called a post-antibiotic
  effect).
 Patients on Gentamicin are monitored to ensure that levels are
  adequate for therapy and to detect elevated levels that may be
  associated with a greater risk of ototoxicity and
  nephrotoxicity.
Peak & Trough (continued)

 Blood must NOT be drawn from the line it was infusing in
 Blood is drawn from a different port, it is NOT drawn from the port
  it was infused in
 Do not wait for trough results before hanging antibiotic unless
  specific order to wait for result is ordered by MD
 Administer antibiotic at prescribed rate so that peak levels will be
  accurate
 If dose is received to infuse over 30 minutes, collect peak 30
  minutes after dose completion
 EXCEPTION – If the dose is ordered to infuse over 60 minutes,
  then the peak is drawn 15 minutes after the infusion is complete

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Peak & trough

  • 1. Peak & Trough  Vancomycin is a glycopeptide antibiotic. It is a time dependent killer. The level has to stay above a minimum concentration for a length of time for the medication to be effective. Thus, Vancomycin doses should not be held while waiting for a trough level.  Vancomycin peak levels are not routinely monitored, however if ordered by the MD, the peak should be drawn 1 hour after medication dose is complete.  Exception – if the ordered dose of Vancomycin is 2 grams or more then obtain the peak 2 hours after the infusion is complete.
  • 2. Peak & Trough (cont)  Collect trough immediately prior to dose  Blood must NOT be drawn from the line it was infusing in  Blood is drawn from a different port, it is NOT drawn from the port it was infused in  Do not draw a trough level while Vancomycin is infusing  Do not wait for trough results before hanging antibiotic unless a specific order to wait for result is ordered by MD  Administer antibiotic at prescribed rate so levels are accurate
  • 3. Peak & Trough (continued) Gentamicin  Gentamicin is an aminoglycoside antibiotic. It works differently. It is a concentration dependent killer. This means the higher the peak concentration, the larger the kill of microorganisms. Gentamicin can kill microorganisms after the concentration has decreased (this is called a post-antibiotic effect).  Patients on Gentamicin are monitored to ensure that levels are adequate for therapy and to detect elevated levels that may be associated with a greater risk of ototoxicity and nephrotoxicity.
  • 4. Peak & Trough (continued)  Blood must NOT be drawn from the line it was infusing in  Blood is drawn from a different port, it is NOT drawn from the port it was infused in  Do not wait for trough results before hanging antibiotic unless specific order to wait for result is ordered by MD  Administer antibiotic at prescribed rate so that peak levels will be accurate  If dose is received to infuse over 30 minutes, collect peak 30 minutes after dose completion  EXCEPTION – If the dose is ordered to infuse over 60 minutes, then the peak is drawn 15 minutes after the infusion is complete