The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis (Q24293460)

GOA release 2020-03-11

Forkhead box O3

1 reference

protein autophosphorylation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Andreas Rosenwald

9

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Matthias Gaestel

5

object named as

Matthias Gaestel

0 references

Ian G Cannell

object named as

Ian G Cannell

2

0 references

Martin Eilers

object named as

Martin Eilers

10

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author name string

Theresia R Kress

1

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Arjan B Brenkman

3

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Birgit Samans

4

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Paul Roepman

6

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Boudewijn M Burgering

7

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Martin Bushell

Distinct thresholds govern Myc's biological output in vivo

8

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language of work or name

English

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publication date

18 February 2011

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published in

Molecular Cell

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volume

41

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issue

4

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page(s)

445-57

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cites work

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

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PRAK is essential for ras-induced senescence and tumor suppression

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Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

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p19ARF directly and differentially controls the functions of c-Myc independently of p53.

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A microRNA component of the p53 tumour suppressor network

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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

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Scaffolding by ERK3 regulates MK5 in development

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Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

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Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

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p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

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The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

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Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

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Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

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Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

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