BCL2 associated agonist of cell death (Q812784)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92934

1 reference

13 November 2019

1 reference

13 November 2019

14-3-3 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein phosphatase binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

protein binding

27 references

8 April 2019

Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

PTH inactivates the AKT survival pathway in the colonic cell line Caco-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Structure homology and interaction redundancy for discovering virus-host protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Protection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

The BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cysteine-type endopeptidase activator activity involved in apoptotic process

phospholipid binding

1 reference

8 April 2019

Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein kinase binding

1 reference

5 June 2018

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

lipid binding

1 reference

8 April 2019

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein phosphatase 2B binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein kinase B binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cysteine-type endopeptidase activator activity involved in apoptotic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein kinase binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

3 references

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

5 June 2018

Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

1 reference

8 April 2019

mitochondrial outer membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

8 April 2019

Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

mitochondrion

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of T cell differentiation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cellular response to hypoxia

1 reference

5 June 2018

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

extrinsic apoptotic signaling pathway

1 reference

5 June 2018

Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

positive regulation of autophagy

1 reference

8 April 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to testosterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of B cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to progesterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of apoptotic process by virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

pore complex assembly

cellular response to nicotine

2 references

1 reference

8 April 2019

Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to glucose

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to calcium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cellular response to mechanical stimulus

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

activation of cysteine-type endopeptidase activity

1 reference

5 June 2018

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

regulation of mitochondrial membrane permeability

1 reference

5 June 2018

Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

1 reference

8 April 2019

positive regulation of intrinsic apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

1 reference

8 April 2019

spermatogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

glucose catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of proteolysis

1 reference

8 April 2019

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cerebral cortex development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cellular response to lipid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of release of cytochrome c from mitochondria

1 reference

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

suppression by virus of host apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

cellular response to chromate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to hydrogen peroxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

response to oleic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

release of cytochrome c from mitochondria

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

apoptotic process

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

8 April 2019

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

intrinsic apoptotic signaling pathway

1 reference

5 June 2018

Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934

apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

1 reference

8 April 2019

positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

positive regulation of apoptotic process

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

8 April 2019

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

regulation of mitochondrial membrane permeability

cellular response to hypoxia

extrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway

positive regulation of granulosa cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934

http://purl.uniprot.org/uniprot/Q92934

Gene Atlas image

PBB GE BAD 1861 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers.org

Identifiers

MeSH descriptor ID

D051025

subject named as

bcl-Associated Death Protein

0 references

MeSH tree code

D12.644.360.075.718.100

0 references

D12.776.476.075.718.100

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

9 August 2016

language of work or name

1 reference

UMLS 2023