Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E. (Q55251496)

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25 March 2020

2 references

14 November 2020

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Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720980%20AND%20SRC:MED&resulttype=core&format=json

regulation of gene expression

25 March 2020

main subject

1 reference

8 September 2019

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28 September 2019

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22 December 2019

22 December 2020

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14 November 2020

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25 March 2020

author name string

Theresa Kordaß

series ordinal

1

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Wolfram Osen

series ordinal

2

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publication date

18 April 2018

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14 November 2020

22 December 2020

Frontiers in Immunology

6 references

8 September 2019

28 September 2019

22 December 2019

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25 March 2020

14 November 2020

22 December 2020

9

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page(s)

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Creative Commons Attribution 4.0 International

25 March 2020

copyright license

5 references

8 September 2019

28 September 2019

22 December 2019

14 November 2020

CD73 promotes resistance to HER2/ErbB2 antibody therapy

22 December 2020

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5915482

Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapies

30 June 2018

1 reference

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MicroRNA-30a regulates cell proliferation and tumor growth of colorectal cancer by targeting CD73.

30 June 2018

1 reference

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Relationship between CD4 Regulatory T Cells and Anergy In Vivo

30 June 2018

1 reference

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The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

30 June 2018

1 reference

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CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer

30 June 2018

1 reference

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Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

30 June 2018

1 reference

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The role of alternative splicing in cancer

30 June 2018

1 reference

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MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF-β pathway via targeting SMAD3.

30 June 2018

1 reference

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Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

30 June 2018

1 reference

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MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4.

30 June 2018

1 reference

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MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.

30 June 2018

1 reference

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miRNA-223 inhibits epithelial-mesenchymal transition in gastric carcinoma cells via Sp1.

30 June 2018

1 reference

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Immunosuppressive activities of adenosine in cancer.

30 June 2018

1 reference

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microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection.

30 June 2018

1 reference

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New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies

30 June 2018

1 reference

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A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

30 June 2018

1 reference

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Anti-CD73 in cancer immunotherapy: awakening new opportunities.

30 June 2018

1 reference

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Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

30 June 2018

1 reference

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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors

30 June 2018

1 reference

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MicroRNA-187, a downstream effector of TGFβ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer

30 June 2018

1 reference

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Hypoxia and metabolic adaptation of cancer cells

30 June 2018

1 reference

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AURA 2: Empowering discovery of post-transcriptional networks

30 June 2018

1 reference

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miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth.

30 June 2018

1 reference

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BioGPS: building your own mash-up of gene annotations and expression profiles

30 June 2018

1 reference

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Rotavirus-induced miR-142-5p elicits proviral milieu by targeting non-canonical transforming growth factor beta signalling and apoptosis in cells

30 June 2018

1 reference

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MiR-495 is a Predictive Biomarker that Downregulates GFI1 Expression in Medulloblastoma

30 June 2018

1 reference

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

30 June 2018

1 reference

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miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway

30 June 2018

1 reference

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The biological functions of miRNAs: lessons from in vivo studies

30 June 2018

1 reference

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Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

30 June 2018

1 reference

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Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73).

30 June 2018

1 reference

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MicroRNAs in cancer: biomarkers, functions and therapy

30 June 2018

1 reference

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Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

30 June 2018

1 reference

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Hallmarks of alternative splicing in cancer

30 June 2018

1 reference

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Inhibition of CD73 stimulates the migration and invasion of B16F10 melanoma cells in vitro, but results in impaired angiogenesis and reduced melanoma growth in vivo

30 June 2018

1 reference

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Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling

30 June 2018

1 reference

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An expression atlas of human primary cells: inference of gene function from coexpression networks

30 June 2018

1 reference

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miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression.

30 June 2018

1 reference

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Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

30 June 2018

1 reference

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CD39 and CD73 in immunity and inflammation

30 June 2018

1 reference

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Ecto-5'-nucleotidase (CD73) promotes tumor angiogenesis

30 June 2018

1 reference

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Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells.

30 June 2018

1 reference

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Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling

30 June 2018

1 reference

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Activated hepatic stellate cells upregulate transcription of ecto-5'-nucleotidase/CD73 via specific SP1 and SMAD promoter elements

30 June 2018

1 reference

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CD73: a potent suppressor of antitumor immune responses

30 June 2018

1 reference

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NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

30 June 2018

1 reference

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miRNA signatures associate with pathogenesis and progression of osteosarcoma

30 June 2018

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MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer.

30 June 2018

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Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells

30 June 2018

1 reference

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Ecto-5'-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line

30 June 2018

1 reference

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CD73: A Novel Target for Cancer Immunotherapy

30 June 2018

1 reference

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Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

30 June 2018

1 reference

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CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice

30 June 2018

1 reference

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The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance

30 June 2018

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Physiological roles for ecto-5'-nucleotidase (CD73).

30 June 2018

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Ecto-5'-nucleotidase: Structure function relationships

30 June 2018

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Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo.

30 June 2018

1 reference

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

30 June 2018

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Ecto-5'-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells.

30 June 2018

1 reference

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Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma.

30 June 2018

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Wnt and beta-catenin signaling target the expression of ecto-5'-nucleotidase and increase extracellular adenosine generation

30 June 2018

1 reference

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Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.

30 June 2018

1 reference

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Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors

30 June 2018

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Translational control by the 3'-UTR: the ends specify the means.

30 June 2018

1 reference

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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

30 June 2018

1 reference

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A greedy algorithm for aligning DNA sequences

30 June 2018

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Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases

30 June 2018

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Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation

30 June 2018

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Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia

30 June 2018

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Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells

30 June 2018

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Activation of ecto-5'-nucleotidase and cardioprotection by ischemic preconditioning

30 June 2018

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Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene

30 June 2018

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CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73

30 June 2018

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A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment.

30 June 2018

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Targeting of NT5E by miR-30b and miR-340 attenuates proliferation, invasion and migration of gallbladder carcinoma

13 August 2018

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Clinical significance of CD73 in triple-negative breast cancer: multiplex analysis of a phase III clinical trial.

13 August 2018

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Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.

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miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss

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The Functional Impact of Alternative Splicing in Cancer

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13 August 2018

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Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.

13 August 2018

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Anti-CD73 therapy impairs tumor angiogenesis

13 August 2018

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Regulation of the Hif-system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation

13 August 2018

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Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer.

13 August 2018

1 reference

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Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5915482

The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5915482

Ecto-5′-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells

13 August 2018

1 reference

12 December 2020

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

1 reference

12 December 2020

CD73 as a novel prognostic biomarker for human colorectal cancer

1 reference

12 December 2020

Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2018.00813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720980%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720980%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PubMed publication ID

29720980

1 reference