Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2) (Q24298459)

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English	Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)	scientific article

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scholarly article

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Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2) (English)

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author name string

Diane Chan

1

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Allison Citro

2

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Joanna M Cordy

3

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Grace C Shen

4

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Benjamin Wolozin

5

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language of work or name

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publication date

6 May 2011

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Journal of Biological Chemistry

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286

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18

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16140-9

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3091223/fullTextXML

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inferred from PubMed Central ID database lookup

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

PAK signalling in neuronal physiology

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

LRRK2 regulates synaptic vesicle endocytosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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19 March 2017

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

19 March 2017

RIP1, a kinase on the crossroads of a cell's decision to live or die

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19 March 2017

LRRK2 in Parkinson's disease: protein domains and functional insights

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19 March 2017

Rho GTPases: biochemistry and biology

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19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

7 April 2017

Parkinson's disease: mechanisms and models

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7 April 2017

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

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7 April 2017

Mammalian Rho GTPases: new insights into their functions from in vivo studies

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7 April 2017

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

7 April 2017

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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7 April 2017

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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7 April 2017

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091223

27 September 2017

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

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27 September 2017

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

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27 September 2017

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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27 September 2017

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

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27 September 2017

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

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27 September 2017

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

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27 September 2017

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

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27 September 2017

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics

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27 September 2017

Genes associated with Parkinson syndrome

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27 September 2017

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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27 September 2017

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

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27 September 2017

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

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27 September 2017

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

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27 September 2017

Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton

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27 September 2017

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

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Understanding ERM proteins--the awesome power of genetics finally brought to bear

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MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease

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