Pages that link to "Q28592373"
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The following pages link to APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development (Q28592373):
Displaying 50 items.
- Nicastrin (Q14911609) (← links)
- Aph1 homolog C, gamma secretase subunit (Q21432647) (← links)
- Aph1 homolog A, gamma secretase subunit (Q21496069) (← links)
- Aph1 homolog B, gamma secretase subunit (Q21496070) (← links)
- Presenilin 1 (Q21496912) (← links)
- Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (Q24306785) (← links)
- Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment (Q24657399) (← links)
- Proteolytic processing of Alzheimer's β-amyloid precursor protein (Q28254104) (← links)
- Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 (Q28277779) (← links)
- Γ-secretase components as predictors of breast cancer outcome (Q28534781) (← links)
- Cross-species genome wide expression analysis during pluripotent cell determination in mouse and rat preimplantation embryos (Q28584193) (← links)
- Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression (Q28585864) (← links)
- Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities (Q28588005) (← links)
- Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin (Q28595013) (← links)
- Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia (Q28600984) (← links)
- Modeling an anti-amyloid combination therapy for Alzheimer's disease (Q30482113) (← links)
- Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies (Q33243260) (← links)
- Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease (Q33327152) (← links)
- gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes (Q33545253) (← links)
- Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases (Q33852318) (← links)
- The secretases: enzymes with therapeutic potential in Alzheimer disease (Q33887222) (← links)
- Characterization of an atypical gamma-secretase complex from hematopoietic origin (Q33892554) (← links)
- Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator (Q33972134) (← links)
- Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. (Q33996381) (← links)
- Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). (Q34003851) (← links)
- Inhibition of BACE1 for therapeutic use in Alzheimer's disease (Q34007475) (← links)
- Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo (Q34091318) (← links)
- Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process (Q34110227) (← links)
- Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB (Q34353695) (← links)
- Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta (Q34656224) (← links)
- The γ-secretase complex: from structure to function (Q34677532) (← links)
- Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex (Q34752171) (← links)
- An overview of notch signaling in adult tissue renewal and maintenance (Q35180702) (← links)
- Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease (Q35658184) (← links)
- Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease (Q36300032) (← links)
- Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment (Q36432181) (← links)
- The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid (Q36582358) (← links)
- A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? (Q36674481) (← links)
- Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease (Q37108151) (← links)
- Presenilins: members of the gamma-secretase quartets, but part-time soloists too. (Q37242236) (← links)
- APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes (Q37269196) (← links)
- gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease (Q37339100) (← links)
- BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis (Q37598601) (← links)
- The structure and function of Alzheimer's gamma secretase enzyme complex. (Q37643736) (← links)
- gamma-secretases: from cell biology to therapeutic strategies (Q37686625) (← links)
- Gamma-secretase and the intramembrane proteolysis of Notch (Q37785197) (← links)
- Proteolytic cleavage of Notch: "HIT and RUN". (Q37867140) (← links)
- Assembly of the presenilin γ-/ε-secretase complex. (Q37961796) (← links)
- Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease. (Q37999086) (← links)
- The very many faces of presenilins and the γ-secretase complex. (Q38090514) (← links)