PARP-1, a determinant of cell survival in response to DNA damage (Q28182341)

Cell cycle checkpoints: preventing an identity crisis

Europe PubMed Central

title

PARP-1, a determinant of cell survival in response to DNA damage (English)

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Véronique J Bouchard

1

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Michèle Rouleau

series ordinal

2

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Guy G Poirier

series ordinal

3

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language of work or name

English

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publication date

June 2003

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published in

Experimental Hematology

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volume

31

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issue

6

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page(s)

446-54

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cites work

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Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

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Poly (ADP-ribosylation)--a common control process?

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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

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A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues

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The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

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Tankyrase promotes telomere elongation in human cells

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

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TCDD-inducible poly (ADP-ribose) polmerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.

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Mode of action of poly(ADP-ribose) glycohydrolase

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Poly(ADP-ribose)polymerase: a novel finger protein

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Coenzymatic activity of randomly broken or intact double-stranded DNAs in auto and histone H1 trans-poly(ADP-ribosylation), catalyzed by poly(ADP-ribose) polymerase (PARP I).

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Identification of domains of poly(ADP-ribose) polymerase for protein binding and self-association

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Random Mutagenesis of the Poly(ADP-ribose) Polymerase Catalytic Domain Reveals Amino Acids Involved in Polymer Branching

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(ADP-ribose)n participates in DNA excision repair

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Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells

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Functional competition between poly(ADP-ribose) polymerase and its 24-kDa apoptotic fragment in DNA repair and transcription

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Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.

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Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

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DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.

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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

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Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair

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Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure

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The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development

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Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

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PARP is important for genomic stability but dispensable in apoptosis

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The DNA damage response: putting checkpoints in perspective

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Poly(ADP-ribose) polymerase: a molecular nick-sensor

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The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells

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Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice

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p53, the cellular gatekeeper for growth and division

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mdm2 expression is induced by wild type p53 activity

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified

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Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

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Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence

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A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate

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PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

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7 January 2021

Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein

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7 January 2021

Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

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Going APE over ref-1.

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A novel function of poly(ADP-ribosyl)ation: silencing of RNA polymerase II-dependent transcription

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A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage

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Transcriptional repression by binding of poly(ADP-ribose) polymerase to promoter sequences

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Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase

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Poly(ADP-ribose) polymerase is a B-MYB coactivator

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Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription

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PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.

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A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

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Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage

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Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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Biochemical determinants of apoptosis and necrosis

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Cell suicide for beginners

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Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

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The role of NADPH oxidase, neuronal nitric oxide synthase and poly(ADP ribose) polymerase in oxidative neuronal death induced in cortical cultures by brain-derived neurotrophic factor and neurotrophin-4/5.

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Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

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Caspases: killer proteases

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Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

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7 January 2021

Inhibition of homodimerization of poly(ADP-ribose) polymerase by its C-terminal cleavage products produced during apoptosis

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

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Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent

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Apoptosis in the absence of poly-(ADP-ribose) polymerase

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Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a

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7 January 2021

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12829019

1 reference

Consolidated OpenCitations Corpus – April 2017