Antimyeloma activity of heat shock protein-90 inhibition. (Q40380103)

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8 January 2020

title

Antimyeloma activity of heat shock protein-90 inhibition (English)

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Gareth J. Morgan

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Towia A Libermann

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Paul G Richardson

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Kenneth C Anderson

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Nikhil C Munshi

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Dharminder Chauhan

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Teru Hideshima

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8 January 2020

Constantine S Mitsiades

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object named as

Constantine S Mitsiades

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Nicholas S Mitsiades

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Vassiliki Poulaki

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Ciaran J McMullan

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Masaharu Akiyama

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Reshma Shringarpure

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Faith E Davies

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8 January 2020

author name string

Xuesong Gu

14

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8 January 2020

Charles Bailey

15

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8 January 2020

Marie Joseph

16

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Neal S Rosen

18

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language of work or name

English

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publication date

18 October 2005

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8 January 2020

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8 January 2020

volume

107

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8 January 2020

issue

3

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8 January 2020

page(s)

1092-1100

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Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

8 January 2020

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1 reference

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Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

22 September 2017

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Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

22 September 2017

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Regulation of Vascular Endothelial Growth Factor Expression by Insulin-Like Growth Factor I in Thyroid Carcinomas

22 September 2017

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

22 September 2017

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Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

22 September 2017

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

22 September 2017

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Heat shock protein 90 as a molecular target for cancer therapeutics

22 September 2017

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Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays

22 September 2017

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Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.

22 September 2017

1 reference

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

22 September 2017

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Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

22 September 2017

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Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

22 September 2017

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NF-kappa B as a therapeutic target in multiple myeloma

22 September 2017

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Novel biologically based therapies for myeloma

22 September 2017

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

22 September 2017

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

22 September 2017

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

22 September 2017

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

22 September 2017

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Cytokines modulate telomerase activity in a human multiple myeloma cell line.

22 September 2017

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The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

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15 June 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

20 August 2018

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17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

20 August 2018

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Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

20 August 2018

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Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

20 August 2018

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

20 August 2018

1 reference

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Characterization of the nontransformed and transformed androgen receptor and heat shock protein 90 with high-performance hydrophobic-interaction chromatography

20 August 2018

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12 December 2020

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1 reference

12 December 2020

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

1 reference

12 December 2020

Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias

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12 December 2020

Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications

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12 December 2020

10.1182/BLOOD-2005-03-1158

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16234364%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16234364%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

16234364

1 reference