solute carrier family 12 member 3 (Q7553281)

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mammalian protein found in Homo sapiens

NaCl electroneutral thiazide-sensitive cotransporter
thiazide-sensitive Na-Cl cotransporter
NCC
Na-Cl cotransporter
thiazide-sensitive sodium-chloride cotransporter
solute carrier family 12 (sodium/chloride transporter), member 3
SLC12A3
solute carrier family 12 member 3
Na-Cl symporter

Language	Label	Description	Also known as
English	solute carrier family 12 member 3	mammalian protein found in Homo sapiens	NaCl electroneutral thiazide-sensitive cotransporter thiazide-sensitive Na-Cl cotransporter NCC Na-Cl cotransporter thiazide-sensitive sodium-chloride cotransporter solute carrier family 12 (sodium/chloride transporter), member 3 SLC12A3 solute carrier family 12 member 3 Na-Cl symporter

Statements

1 reference

13 November 2019

UniProt protein ID

Thiazide-sensitive Na-K-Cl co-transporter

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55017

SLC12A transporter, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Amino acid permease, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Amino acid permease/ SLC12A domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NCC protein.png
1,920 × 975; 957 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cation:chloride symporter activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

symporter activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

transporter activity

determination method or standard

sodium:potassium:chloride symporter activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

sodium ion transmembrane transporter activity

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

sodium:chloride symporter activity

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

potassium:chloride symporter activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

transporter activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

sodium ion transmembrane transporter activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

plasma membrane

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

extracellular exosome

determination method or standard

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

apical plasma membrane

determination method or standard

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

determination method or standard

3 references

8 April 2019

Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

apical plasma membrane

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

extracellular exosome

determination method or standard

3 references

8 April 2019

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

biological process

chloride transmembrane transport

determination method or standard

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

determination method or standard

sodium ion transmembrane transport

determination method or standard

1 reference

26 September 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

sodium ion transport

determination method or standard

transmembrane transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

chloride transport

determination method or standard

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

determination method or standard

4 references

26 September 2017

Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55017&geneProductId=UniProtKB:P55017

determination method or standard

cell volume homeostasis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

chloride ion homeostasis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

potassium ion homeostasis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

sodium ion homeostasis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

chloride transmembrane transport

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

potassium ion import across plasma membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55017

determination method or standard

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

hydrochlorothiazide

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL406

bendroflumethiazide

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1684

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL878

trichlormethiazide

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1054

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL842

Amino acid permease, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55017

Amino acid permease/ SLC12A domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55017

SLC12A transporter, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55017

Identifiers

MeSH descriptor ID

subject named as

Solute Carrier Family 12, Member 3

0 references

D12.776.157.530.450.625.374.500

0 references

D12.776.157.530.937.750.750

0 references

D12.776.543.585.937.875.750

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000457552

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457552

ENSP00000402152

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402152

ENSP00000456149

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456149

ENSP00000262502

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000262502

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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