GPRC5B: Difference between revisions

GPRC5B
Identifiers
Aliases	GPRC5B, RAIG-2, RAIG2, G protein-coupled receptor class C group 5 member B
External IDs	OMIM: 605948; MGI: 1927596; HomoloGene: 9435; GeneCards: GPRC5B; OMA:GPRC5B - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	19,886,167 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	118,594,434 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; dorsal motor nucleus of vagus nerve; ; middle frontal gyrus; ; external globus pallidus; ; subthalamic nucleus; ; superior vestibular nucleus; ; ventral tegmental area; ; C1 segment;
	Top expressed in
	epithelium of lens; ; deep cerebellar nuclei; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; lobe of cerebellum; ; cerebellar vermis; ; saccule; ; medial vestibular nucleus; ; substantia nigra; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein kinase activator activity; G protein-coupled receptor binding; protein kinase binding;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; nucleolus; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; nucleus; extracellular space; cytosol; cell surface; receptor complex;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; activation of protein kinase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron differentiation; positive regulation of inflammatory response; positive regulation of macrophage cytokine production; positive regulation of protein tyrosine kinase activity; positive regulation of canonical Wnt signaling pathway; locomotory behavior; positive regulation of neuron projection development; glucose homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	51704
	64297
	ENSG00000167191
	ENSMUSG00000008734
	Q9NZH0
	Q923Z0
	NM_001304771; NM_016235
	NM_001195774; NM_022420
	NP_001291700; NP_057319
	NP_001182703; NP_071865
	Wikidata
View/Edit Human	View/Edit Mouse

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G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008734 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
^ Bräuner-Osborne H, Krogsgaard-Larsen P (Jul 2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
^ ^a ^b "Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B".

External links

"GPRC5 Receptors: RAIG₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-08-08. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008734 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10493829-5] Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

[pmid10783259-6] Bräuner-Osborne H, Krogsgaard-Larsen P (Jul 2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.

[entrez-7] "Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B".

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[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''G-protein coupled receptor family C group 5 member B''' is a [[protein]] that in humans is encoded by the ''GPRC5B'' [[gene]].<ref name="pmid10493829">{{cite journal |vauthors=Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | date = Nov 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}</ref><ref name="pmid10783259">{{cite journal |vauthors=Bräuner-Osborne H, Krogsgaard-Larsen P | title = Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain | journal = Genomics | volume = 65 | issue = 2 | pages = 121–8 | date = Jul 2000 | pmid = 10783259 | doi = 10.1006/geno.2000.6164 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Function ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = G protein-coupled receptor, family C, group 5, member B
- | HGNCid = 13308
- | Symbol = GPRC5B
- | AltSymbols =; RAIG-2; RAIG2
- | OMIM = 605948
- | ECnumber =
- | Homologene = 9435
- | MGIid = 1927596
- | GeneAtlas_image1 = PBB_GE_GPRC5B_203632_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_GPRC5B_203631_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005118 |text = sevenless binding}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 51704
-    | Hs_Ensembl = ENSG00000167191
-    | Hs_RefseqProtein = NP_057319
-    | Hs_RefseqmRNA = NM_016235
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 19777796
-    | Hs_GenLoc_end = 19803652
-    | Hs_Uniprot = Q9NZH0
-    | Mm_EntrezGene = 64297
-    | Mm_Ensembl = ENSMUSG00000008734
-    | Mm_RefseqmRNA = NM_022420
-    | Mm_RefseqProtein = NP_071865
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 118763196
-    | Mm_GenLoc_end = 118786310
-    | Mm_Uniprot = Q9JMF0
-  }}
-}}
-'''G protein-coupled receptor, family C, group 5, member B''', also known as '''GPRC5B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704| accessdate = }}</ref>
+The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.<ref name="entrez" />
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704| accessdate = }}</ref>
-}}
 ==See also==
@@ Line 62: / Line 14: @@
 ==Further reading==
-{{refbegin | 2}}
+{{refbegin}}
+*{{cite journal |vauthors=Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN | title = Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) | journal = Genomics | volume = 67 | issue = 1 | pages = 8–18 | year = 2001 | pmid = 10945465 | doi = 10.1006/geno.2000.6226 }}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
-*{{cite journal  | author=Bräuner-Osborne H, Krogsgaard-Larsen P |title=Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. |journal=Genomics |volume=65 |issue= 2 |pages= 121–8 |year= 2000 |pmid= 10783259 |doi= 10.1006/geno.2000.6164 }}
-*{{cite journal  | author=Robbins MJ, Michalovich D, Hill J, ''et al.'' |title=Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). |journal=Genomics |volume=67 |issue= 1 |pages= 8–18 |year= 2001 |pmid= 10945465 |doi= 10.1006/geno.2000.6226 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-}}
 {{refend}}
+==External links==
-{{transmembranereceptor-stub}}
+*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2960 | title = GPRC5 Receptors: RAIG<sub>2</sub> | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2014-08-08 | archive-url = https://web.archive.org/web/20140808051224/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2960 | url-status = dead }}
 {{NLM content}}
-{{G protein-coupled receptors}}
+{{G protein-coupled receptors|g3}}
-[[Category:G protein coupled receptors]]
+[[Category:G protein-coupled receptors]]
+{{transmembranereceptor-stub}}