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{{cs1 config|name-list-style=vanc}}
{{PBB|geneid=898}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
⚫
'''G1/S-specific cyclin-E1''' is a [[protein]] that in humans is encoded by the ''CCNE1'' [[gene]].<ref name="pmid1833066">{{cite journal | vauthors = Lew DJ, Dulić V, Reed SI | title = Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast | journal = Cell | volume = 66 | issue = 6 | pages = 1197–206 | date = October 1991 | pmid = 1833066 | pmc = | doi = 10.1016/0092-8674(91)90042-W }}</ref>
{{Infobox_gene}}
⚫
'''G1/S-specific cyclin-E1''' is a [[protein]] that in humans is encoded by the ''CCNE1'' [[gene]].<ref name="pmid1833066">{{cite journal | vauthors = Lew DJ, Dulić V, Reed SI | title = Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast | journal = Cell | volume = 66 | issue = 6 | pages = 1197–206 | date = October 1991 | pmid = 1833066 | doi = 10.1016/0092-8674(91)90042-W | s2cid = 12166415 }}</ref>


== Function ==
== Function ==


The protein encoded by this gene belongs to the [[Highly conserved sequence|highly conserved]] [[Cyclin|cyclin family]], whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of [[Cyclin-dependent kinase|CDK kinases]]. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each [[mitosis|mitotic]] event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to [[tumorigenesis]]. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.<ref name="entrez">{{Cite web| title = Entrez Gene: CCNE1 cyclin E1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=898| accessdate = }}</ref>
The protein encoded by this gene belongs to the [[Highly conserved sequence|highly conserved]] [[Cyclin|cyclin family]], whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of [[Cyclin-dependent kinase|CDK]]. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each [[mitosis|mitotic]] event. This cyclin forms a complex with and functions as a regulatory subunit of [[CDK2]], whose activity is required for cell cycle [[G1/S transition]]. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to [[tumorigenesis]]. This protein was found to associate with, and be involved in, the phosphorylation of [[NPAT (gene)|NPAT]] protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.<ref name="entrez">{{Cite web| title = Entrez Gene: CCNE1 cyclin E1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=898}}</ref>


== Interactions ==
== Interactions ==
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Cyclin E1 has been shown to [[Protein-protein interaction|interact]] with:
Cyclin E1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
{{div col|colwidth=20em}}
* [[CDC25A]],<ref name = pmid9891079/><ref name = pmid8617791>{{cite journal | vauthors = Xu X, Burke SP | title = Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25 | journal = J. Biol. Chem. | volume = 271 | issue = 9 | pages = 5118–24 | date = March 1996 | pmid = 8617791 | doi = 10.1074/jbc.271.9.5118}}</ref>
* [[CDC25A]],<ref name = pmid9891079/><ref name = pmid8617791>{{cite journal | vauthors = Xu X, Burke SP | title = Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25 | journal = J. Biol. Chem. | volume = 271 | issue = 9 | pages = 5118–24 | date = March 1996 | pmid = 8617791 | doi = 10.1074/jbc.271.9.5118| doi-access = free }}</ref>
* [[CDKN1B]],<ref name = pmid9891079/><ref name = pmid12529437/>
* [[CDKN1B]],<ref name = pmid9891079/><ref name = pmid12529437/>
* [[CUL3]]<ref name = pmid10500095>{{cite journal | vauthors = Singer JD, Gurian-West M, Clurman B, Roberts JM | title = Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | journal = Genes Dev. | volume = 13 | issue = 18 | pages = 2375–87 | date = September 1999 | pmid = 10500095 | pmc = 317026 | doi = 10.1101/gad.13.18.2375}}</ref>
* [[CUL3]]<ref name = pmid10500095>{{cite journal | vauthors = Singer JD, Gurian-West M, Clurman B, Roberts JM | title = Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | journal = Genes Dev. | volume = 13 | issue = 18 | pages = 2375–87 | date = September 1999 | pmid = 10500095 | pmc = 317026 | doi = 10.1101/gad.13.18.2375}}</ref>
* [[Cdk1]],<ref name = pmid9891079/><ref name = pmid1388288>{{cite journal | vauthors = Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM | title = Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle | journal = Science | volume = 257 | issue = 5077 | pages = 1689–94 | date = September 1992 | pmid = 1388288 | doi = 10.1126/science.1388288}}</ref>
* [[Cdk1]],<ref name = pmid9891079/><ref name = pmid1388288>{{cite journal | vauthors = Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM | title = Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle | journal = Science | volume = 257 | issue = 5077 | pages = 1689–94 | date = September 1992 | pmid = 1388288 | doi = 10.1126/science.1388288| bibcode = 1992Sci...257.1689K }}</ref>
* [[Cyclin-dependent kinase 2]],<ref name = pmid9891079/><ref name = pmid12529437>{{cite journal | vauthors = Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM | title = CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis | journal = Mol. Biol. Cell | volume = 14 | issue = 1 | pages = 201–13 | date = January 2003 | pmid = 12529437 | pmc = 140238 | doi = 10.1091/mbc.E02-06-0319 }}</ref><ref name = pmid1388288/><ref name = pmid12839982>{{cite journal | vauthors = McKenzie PP, Danks MK, Kriwacki RW, Harris LC | title = P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest | journal = Cancer Res. | volume = 63 | issue = 13 | pages = 3840–4 | date = July 2003 | pmid = 12839982 | doi = }}</ref><ref name = pmid15004009>{{cite journal | vauthors = Mayer C, Zhao J, Yuan X, Grummt I | title = mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability | journal = Genes Dev. | volume = 18 | issue = 4 | pages = 423–34 | date = February 2004 | pmid = 15004009 | pmc = 359396 | doi = 10.1101/gad.285504 }}</ref><ref name = pmid10827081>{{cite journal | vauthors = Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M | title = NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25411–7 | date = August 2000 | pmid = 10827081 | doi = 10.1074/jbc.M001676200 }}</ref>
* [[Cyclin-dependent kinase 2]],<ref name = pmid9891079/><ref name = pmid12529437>{{cite journal | vauthors = Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM | title = CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis | journal = Mol. Biol. Cell | volume = 14 | issue = 1 | pages = 201–13 | date = January 2003 | pmid = 12529437 | pmc = 140238 | doi = 10.1091/mbc.E02-06-0319 }}</ref><ref name = pmid1388288/><ref name = pmid12839982>{{cite journal | vauthors = McKenzie PP, Danks MK, Kriwacki RW, Harris LC | title = P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest | journal = Cancer Res. | volume = 63 | issue = 13 | pages = 3840–4 | date = July 2003 | pmid = 12839982 }}</ref><ref name = pmid15004009>{{cite journal | vauthors = Mayer C, Zhao J, Yuan X, Grummt I | title = mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability | journal = Genes Dev. | volume = 18 | issue = 4 | pages = 423–34 | date = February 2004 | pmid = 15004009 | pmc = 359396 | doi = 10.1101/gad.285504 }}</ref><ref name = pmid10827081>{{cite journal | vauthors = Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M | title = NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25411–7 | date = August 2000 | pmid = 10827081 | doi = 10.1074/jbc.M001676200 | doi-access = free }}</ref>
* [[HERC5]],<ref name = pmid10581175>{{cite journal | vauthors = Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M | title = A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins | journal = Biochem. Biophys. Res. Commun. | volume = 266 | issue = 1 | pages = 115–22 | date = December 1999 | pmid = 10581175 | doi = 10.1006/bbrc.1999.1777 }}</ref>
* [[HERC5]],<ref name = pmid10581175>{{cite journal | vauthors = Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M | title = A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins | journal = Biochem. Biophys. Res. Commun. | volume = 266 | issue = 1 | pages = 115–22 | date = December 1999 | pmid = 10581175 | doi = 10.1006/bbrc.1999.1777 }}</ref>
* [[P21]],<ref name = pmid12839982/>
* [[P21]],<ref name = pmid12839982/>
* [[Retinoblastoma-like protein 2]],<ref name = pmid9891079>{{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | journal = Mol. Cell. Biol. | volume = 19 | issue = 2 | pages = 1460–9 | date = February 1999 | pmid = 9891079 | pmc = 116074 | doi = }}</ref><ref name = pmid8253383>{{cite journal | vauthors = Li Y, Graham C, Lacy S, Duncan AM, Whyte P | title = The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E | journal = Genes Dev. | volume = 7 | issue = 12A | pages = 2366–77 | date = December 1993 | pmid = 8253383 | doi = 10.1101/gad.7.12a.2366}}</ref> and
* [[Retinoblastoma-like protein 2]],<ref name = pmid9891079>{{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | journal = Mol. Cell. Biol. | volume = 19 | issue = 2 | pages = 1460–9 | date = February 1999 | pmid = 9891079 | pmc = 116074 | doi = 10.1128/mcb.19.2.1460}}</ref><ref name = pmid8253383>{{cite journal | vauthors = Li Y, Graham C, Lacy S, Duncan AM, Whyte P | title = The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E | journal = Genes Dev. | volume = 7 | issue = 12A | pages = 2366–77 | date = December 1993 | pmid = 8253383 | doi = 10.1101/gad.7.12a.2366| doi-access = free }}</ref> and
* [[SMARCA4]].<ref name = pmid9891079/><ref name = pmid11085541>{{cite journal | vauthors = Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E | title = BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 6171–7 | date = November 2000 | pmid = 11085541 | doi = }}</ref>
* [[SMARCA4]].<ref name = pmid9891079/><ref name = pmid11085541>{{cite journal | vauthors = Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E | title = BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 6171–7 | date = November 2000 | pmid = 11085541 }}</ref>
{{Div col end}}
{{Div col end}}


== See also ==
== See also ==
* [[cyclin E]]
* [[Cyclin E]]
* [[Cyclin E/Cdk2]]
{{Clear}}
{{Clear}}


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== Further reading ==
== Further reading ==
{{Refbegin|35em}}
{{Refbegin|35em}}
* {{cite journal | vauthors = Akita H | title = [Prognostic importance of altered expression of cell cycle regulators in lung cancer] | journal = Nippon Rinsho | volume = Suppl 5 | issue = | pages = 267–71 | year = 2003 | pmid = 12101670 | doi = | series = 60 }}
* {{cite journal | vauthors = Akita H | title = [Prognostic importance of altered expression of cell cycle regulators in lung cancer] | journal = Nippon Rinsho | volume = Suppl 5 | pages = 267–71 | year = 2003 | pmid = 12101670 | series = 60 }}
* {{cite journal | vauthors = Mazumder S, DuPree EL, Almasan A | title = A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. | journal = Current cancer drug targets | volume = 4 | issue = 1 | pages = 65–75 | year = 2004 | pmid = 14965268 | pmc = 1307511 | doi = 10.2174/1568009043481669 }}
* {{cite journal | vauthors = Mazumder S, DuPree EL, Almasan A | title = A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. | journal = [[Current Cancer Drug Targets]] | volume = 4 | issue = 1 | pages = 65–75 | year = 2004 | pmid = 14965268 | pmc = 1307511 | doi = 10.2174/1568009043481669 }}
* {{cite journal | vauthors = Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA | title = Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. | journal = Cell | volume = 70 | issue = 6 | pages = 993–1006 | year = 1992 | pmid = 1388095 | doi = 10.1016/0092-8674(92)90249-C }}
* {{cite journal | vauthors = Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA | title = Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. | journal = Cell | volume = 70 | issue = 6 | pages = 993–1006 | year = 1992 | pmid = 1388095 | doi = 10.1016/0092-8674(92)90249-C | s2cid = 30799229 }}
* {{cite journal | vauthors = Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM | title = Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. | journal = Science | volume = 257 | issue = 5077 | pages = 1689–94 | year = 1992 | pmid = 1388288 | doi = 10.1126/science.1388288 }}
* {{cite journal | vauthors = Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM | title = Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. | journal = Science | volume = 257 | issue = 5077 | pages = 1689–94 | year = 1992 | pmid = 1388288 | doi = 10.1126/science.1388288 | bibcode = 1992Sci...257.1689K }}
* {{cite journal | vauthors = Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM | title = Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. | journal = Cell | volume = 66 | issue = 6 | pages = 1217–28 | year = 1991 | pmid = 1833068 | doi = 10.1016/0092-8674(91)90044-Y }}
* {{cite journal | vauthors = Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM | title = Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. | journal = Cell | volume = 66 | issue = 6 | pages = 1217–28 | year = 1991 | pmid = 1833068 | doi = 10.1016/0092-8674(91)90044-Y | s2cid = 38910227 }}
* {{cite journal | vauthors = Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH | title = Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). | journal = Cytogenet. Cell Genet. | volume = 69 | issue = 3-4 | pages = 190–2 | year = 1995 | pmid = 7698009 | doi = 10.1159/000133960 }}
* {{cite journal | vauthors = Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH | title = Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). | journal = Cytogenet. Cell Genet. | volume = 69 | issue = 3–4 | pages = 190–2 | year = 1995 | pmid = 7698009 | doi = 10.1159/000133960 }}
* {{cite journal | vauthors = Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M | title = Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2612–24 | year = 1995 | pmid = 7739542 | pmc = 230491 | doi = }}
* {{cite journal | vauthors = Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M | title = Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2612–24 | year = 1995 | pmid = 7739542 | pmc = 230491 | doi = 10.1128/mcb.15.5.2612}}
* {{cite journal | vauthors = Sewing A, Rönicke V, Bürger C, Funk M, Müller R | title = Alternative splicing of human cyclin E. | journal = J. Cell. Sci. | volume = ( Pt 2) | issue = | pages = 581–8 | year = 1994 | pmid = 8207080 | doi = | series = 107 }}
* {{cite journal | vauthors = Sewing A, Rönicke V, Bürger C, Funk M, Müller R | title = Alternative splicing of human cyclin E. | journal = J. Cell Sci. | volume = ( Pt 2) | pages = 581–8 | year = 1994 | pmid = 8207080 | series = 107 | issue = 2 | doi = 10.1242/jcs.107.2.581 }}
* {{cite journal | vauthors = Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K | title = Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. | journal = J. Virol. | volume = 67 | issue = 12 | pages = 7641–7 | year = 1993 | pmid = 8230483 | pmc = 238233 | doi = }}
* {{cite journal | vauthors = Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K | title = Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. | journal = J. Virol. | volume = 67 | issue = 12 | pages = 7641–7 | year = 1993 | pmid = 8230483 | pmc = 238233 | doi = 10.1128/JVI.67.12.7641-7647.1993}}
* {{cite journal | vauthors = Li Y, Graham C, Lacy S, Duncan AM, Whyte P | title = The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. | journal = Genes Dev. | volume = 7 | issue = 12A | pages = 2366–77 | year = 1994 | pmid = 8253383 | doi = 10.1101/gad.7.12a.2366 }}
* {{cite journal | vauthors = Li Y, Graham C, Lacy S, Duncan AM, Whyte P | title = The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. | journal = Genes Dev. | volume = 7 | issue = 12A | pages = 2366–77 | year = 1994 | pmid = 8253383 | doi = 10.1101/gad.7.12a.2366 | doi-access = free }}
* {{cite journal | vauthors = Xu X, Burke SP | title = Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25. | journal = J. Biol. Chem. | volume = 271 | issue = 9 | pages = 5118–24 | year = 1996 | pmid = 8617791 | doi = 10.1074/jbc.271.9.5118 }}
* {{cite journal | vauthors = Xu X, Burke SP | title = Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25. | journal = J. Biol. Chem. | volume = 271 | issue = 9 | pages = 5118–24 | year = 1996 | pmid = 8617791 | doi = 10.1074/jbc.271.9.5118 | doi-access = free }}
* {{cite journal | vauthors = Ohtani K, DeGregori J, Nevins JR | title = Regulation of the cyclin E gene by transcription factor E2F1. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 26 | pages = 12146–50 | year = 1996 | pmid = 8618861 | pmc = 40313 | doi = 10.1073/pnas.92.26.12146 }}
* {{cite journal | vauthors = Ohtani K, DeGregori J, Nevins JR | title = Regulation of the cyclin E gene by transcription factor E2F1. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 26 | pages = 12146–50 | year = 1996 | pmid = 8618861 | pmc = 40313 | doi = 10.1073/pnas.92.26.12146 | doi-access = free }}
* {{cite journal | vauthors = Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA | title = Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. | journal = Oncogene | volume = 12 | issue = 6 | pages = 1173–80 | year = 1996 | pmid = 8649818 | doi = }}
* {{cite journal | vauthors = Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA | title = Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. | journal = Oncogene | volume = 12 | issue = 6 | pages = 1173–80 | year = 1996 | pmid = 8649818 }}
* {{cite journal | vauthors = Poon RY, Jiang W, Toyoshima H, Hunter T | title = Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. | journal = J. Biol. Chem. | volume = 271 | issue = 22 | pages = 13283–91 | year = 1996 | pmid = 8662825 | doi = 10.1074/jbc.271.22.13283 }}
* {{cite journal | vauthors = Poon RY, Jiang W, Toyoshima H, Hunter T | title = Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. | journal = J. Biol. Chem. | volume = 271 | issue = 22 | pages = 13283–91 | year = 1996 | pmid = 8662825 | doi = 10.1074/jbc.271.22.13283 | doi-access = free }}
* {{cite journal | vauthors = Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A | title = Cyclin-binding motifs are essential for the function of p21CIP1. | journal = Mol. Cell. Biol. | volume = 16 | issue = 9 | pages = 4673–82 | year = 1996 | pmid = 8756624 | pmc = 231467 | doi = }}
* {{cite journal | vauthors = Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A | title = Cyclin-binding motifs are essential for the function of p21CIP1. | journal = Mol. Cell. Biol. | volume = 16 | issue = 9 | pages = 4673–82 | year = 1996 | pmid = 8756624 | pmc = 231467 | doi = 10.1128/MCB.16.9.4673}}
* {{cite journal | vauthors = Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ | title = Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. | journal = Genomics | volume = 32 | issue = 2 | pages = 253–9 | year = 1997 | pmid = 8833152 | doi = 10.1006/geno.1996.0112 }}
* {{cite journal | vauthors = Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ | title = Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. | journal = Genomics | volume = 32 | issue = 2 | pages = 253–9 | year = 1997 | pmid = 8833152 | doi = 10.1006/geno.1996.0112 }}
* {{cite journal | vauthors = Won KA, Reed SI | title = Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. | journal = EMBO J. | volume = 15 | issue = 16 | pages = 4182–93 | year = 1996 | pmid = 8861947 | pmc = 452142 | doi = }}
* {{cite journal | vauthors = Won KA, Reed SI | title = Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. | journal = EMBO J. | volume = 15 | issue = 16 | pages = 4182–93 | year = 1996 | pmid = 8861947 | pmc = 452142 | doi = 10.1002/j.1460-2075.1996.tb00793.x}}
* {{cite journal | vauthors = Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C | title = Activation of human B-MYB by cyclins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 2 | pages = 532–6 | year = 1997 | pmid = 9012818 | pmc = 19547 | doi = 10.1073/pnas.94.2.532 }}
* {{cite journal | vauthors = Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C | title = Activation of human B-MYB by cyclins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 2 | pages = 532–6 | year = 1997 | pmid = 9012818 | pmc = 19547 | doi = 10.1073/pnas.94.2.532 | bibcode = 1997PNAS...94..532S | doi-access = free }}
* {{cite journal | vauthors = Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R | title = Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation. | journal = Nucleic Acids Res. | volume = 25 | issue = 11 | pages = 2098–105 | year = 1997 | pmid = 9153308 | pmc = 146711 | doi = 10.1093/nar/25.11.2098 }}
* {{cite journal | vauthors = Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R | title = Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation. | journal = Nucleic Acids Res. | volume = 25 | issue = 11 | pages = 2098–105 | year = 1997 | pmid = 9153308 | pmc = 146711 | doi = 10.1093/nar/25.11.2098 }}
{{Refend}}
{{Refend}}
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{{Cell cycle proteins}}
{{Cell cycle proteins}}


[[Category:Cell cycle regulators]]

{{Gene-19-stub}}

Latest revision as of 21:44, 25 May 2024

CCNE1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCNE1, CCNE, pcyclin E1
External IDsOMIM: 123837; MGI: 88316; HomoloGene: 14452; GeneCards: CCNE1; OMA:CCNE1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

898

12447

Ensembl

ENSG00000105173

ENSMUSG00000002068

UniProt

P24864

Q61457

RefSeq (mRNA)

NM_001238
NM_057182
NM_001322259
NM_001322261
NM_001322262

NM_007633

RefSeq (protein)

NP_031659

Location (UCSC)Chr 19: 29.81 – 29.82 MbChr 7: 37.8 – 37.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.[5]

Function

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.[6]

Interactions

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Cyclin E1 has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105173 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002068 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
  6. ^ "Entrez Gene: CCNE1 cyclin E1".
  7. ^ a b c d e f Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
  8. ^ Xu X, Burke SP (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.
  9. ^ a b Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell. 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. PMC 140238. PMID 12529437.
  10. ^ Singer JD, Gurian-West M, Clurman B, Roberts JM (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.
  11. ^ a b Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. Bibcode:1992Sci...257.1689K. doi:10.1126/science.1388288. PMID 1388288.
  12. ^ a b McKenzie PP, Danks MK, Kriwacki RW, Harris LC (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. 63 (13): 3840–4. PMID 12839982.
  13. ^ Mayer C, Zhao J, Yuan X, Grummt I (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
  14. ^ Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
  15. ^ Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
  16. ^ Li Y, Graham C, Lacy S, Duncan AM, Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
  17. ^ Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. 60 (21): 6171–7. PMID 11085541.

Further reading

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