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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Probable G-protein coupled receptor 26''' is a [[protein]] that in humans is encoded by the ''GPR26'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR26 G protein-coupled receptor 26| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2849}}</ref> ''GPR26'' expression is found to peak [[Prenatal development|perinatally]], when the visual system is first challenged, and contains a 53 kb [[Linkage disequilibrium|LD]]-block enriched for association with introgressed [[Neanderthal]]-derived SNPs. Additionally, it is known to form oligomeric structures with the [[5-HT1A receptor|5-HT1a receptor]].<ref>{{cite journal | vauthors = Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, Chen Q, Weinberger DR, Saad ZS, Berman KF | display-authors = 6 | title = Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain | journal = Scientific Reports | volume = 7 | issue = 1 | pages = 6308 | date = July 2017 | pmid = 28740249 | pmc = 5524936 | doi = 10.1038/s41598-017-06587-0 }}</ref>
'''Probable G-protein coupled receptor 26''' is a [[protein]] that in humans is encoded by the ''GPR26'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR26 G protein-coupled receptor 26| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2849}}</ref> ''GPR26'' expression is found to peak [[Prenatal development|perinatally]], when the visual system is first challenged, and contains a 53 kb [[Linkage disequilibrium|LD]]-block enriched for association with introgressed [[Neanderthal]]-derived SNPs. Additionally, it is known to form oligomeric structures with the [[5-HT1A receptor|5-HT1a receptor]].<ref>{{cite journal | vauthors = Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, Chen Q, Weinberger DR, Saad ZS, Berman KF | display-authors = 6 | title = Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain | journal = Scientific Reports | volume = 7 | issue = 1 | pages = 6308 | date = July 2017 | pmid = 28740249 | pmc = 5524936 | doi = 10.1038/s41598-017-06587-0 | bibcode = 2017NatSR...7.6308G }}</ref>


== References ==
== References ==
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{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC | title = Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library | journal = Nature Genetics | volume = 4 | issue = 4 | pages = 373–380 | date = August 1993 | pmid = 8401585 | doi = 10.1038/ng0893-373 | s2cid = 12612300 }}
* {{cite journal | vauthors = Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC | title = Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library | journal = Nature Genetics | volume = 4 | issue = 4 | pages = 373–380 | date = August 1993 | pmid = 8401585 | doi = 10.1038/ng0893-373 | s2cid = 12612300 }}
* {{cite journal | vauthors = Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A | display-authors = 6 | title = Cloning and characterization of additional members of the G protein-coupled receptor family | journal = Biochimica et Biophysica Acta | volume = 1490 | issue = 3 | pages = 311–323 | date = February 2000 | pmid = 10684976 | doi = 10.1016/s0167-4781(99)00241-9 }}
* {{cite journal | vauthors = Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A | display-authors = 6 | title = Cloning and characterization of additional members of the G protein-coupled receptor family | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1490 | issue = 3 | pages = 311–323 | date = February 2000 | pmid = 10684976 | doi = 10.1016/s0167-4781(99)00241-9 }}
* {{cite journal | vauthors = Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC | display-authors = 6 | title = Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15482–15485 | date = May 2002 | pmid = 11854302 | doi = 10.1074/jbc.M201539200 | doi-access = free }}
* {{cite journal | vauthors = Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC | display-authors = 6 | title = Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15482–15485 | date = May 2002 | pmid = 11854302 | doi = 10.1074/jbc.M201539200 | doi-access = free }}
{{refend}}
{{refend}}

Latest revision as of 06:02, 22 June 2022

GPR26
Identifiers
AliasesGPR26, G protein-coupled receptor 26
External IDsOMIM: 604847; MGI: 2441758; HomoloGene: 17764; GeneCards: GPR26; OMA:GPR26 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2849

233919

Ensembl

ENSG00000154478

ENSMUSG00000040125

UniProt

Q8NDV2

Q8BZA7

RefSeq (mRNA)

NM_153442

NM_173410

RefSeq (protein)

NP_703143

NP_775586

Location (UCSC)Chr 10: 123.67 – 123.7 MbChr 7: 131.57 – 131.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene.[5] GPR26 expression is found to peak perinatally, when the visual system is first challenged, and contains a 53 kb LD-block enriched for association with introgressed Neanderthal-derived SNPs. Additionally, it is known to form oligomeric structures with the 5-HT1a receptor.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154478 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040125 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR26 G protein-coupled receptor 26".
  6. ^ Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. (July 2017). "Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain". Scientific Reports. 7 (1): 6308. Bibcode:2017NatSR...7.6308G. doi:10.1038/s41598-017-06587-0. PMC 5524936. PMID 28740249.

Further reading

[edit]
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