Talk:Drug metabolism

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I would agree to this merge. The Phase I metabolism article is poorly written and contributes little that isn't already covered in this main article. - strych 20:33, 29 January 2007 (UTC)

It would also be beneficial to give examples. for examples, various drugs undergo different metabolisms. Some only require phase I metabolism for activation or inactivation, followed by phase II. others only Phase II. Still others undergo phase II prior to Phase I. Examples of these, if they can be found easily enough would benefit myself and others in their research. D.F.

Merge as above, please. RupertMillard (Talk) 07:36, 30 January 2007 (UTC)

Merge completed in 2007. Boghog (talk) 12:54, 29 December 2012 (UTC)

Technical

What are the polar bodies referred-to in the section on phase-I and phase-II metabolism? 69.140.152.55 (talk) 01:26, 22 October 2008 (UTC)

Citations needed!!

Please add citations!!! —Preceding unsigned comment added by 24.29.168.166 (talk) 03:34, 21 December 2008 (UTC)

Repetition from xenobiotic metabolism

This article is very similar to xenobiotic metabolism, and in fact, drug metabolism is a sub category of xenobiotic metabolism. It may be difficult to distinguish between the two concepts, since many if not most xenobiotics can act as "drugs" in the body. Therefore, these two articles cover much of the same ground. Perhaps a merge is in order? Also, the concepts of Phase I and Phase II reactions seem to be dealt with better on the xenobiotic metabolism page. Mba123 (talk) 01:46, 11 May 2009 (UTC) mba123

Agreed. I have therefore been bold and merged xenobiotic metabolism into this one. Boghog (talk) 12:54, 29 December 2012 (UTC)

Strongly disagree, xenobiotics include drugs, poisons, and a multitude of natural organic compounds. How do the sections on "Endogenous toxins" and oxidants fit into this "drug metabolism" article? This isn't good. You've merged a top-level article into an article on a sub-category. I'm going to reinstate the original article. Indeed, we need to expand the top-level article to cover things like the evolution of xenobiotic metabolism and the differences between these pathways in microbes, animals and plants, none of which easily fits under drug metabolism. Tim Vickers (talk) 14:34, 17 May 2024 (UTC)

Strange passage

"Simple hydrolysis in the stomach transforms, which are comparatively innocuous."(???????????????). What is meant here and has something been removed? — Preceding unsigned comment added by 81.151.231.65 (talk) 21:30, 4 November 2012 (UTC)

I have edited the passage in an attempt to make the sentence clearer. Boghog (talk) 12:54, 29 December 2012 (UTC)

Merge in From Detoxication

Article merged: See old talk-page here. Klbrain (talk) 21:24, 4 October 2015 (UTC)

Biphasic

[[Lidocaine#Pharmacokinetics] includes the sentence "The elimination half-life of lidocaine is biphasic and around 90–120 minutes in most patients." I wanted to wikilink the technical term "biphasic." The biphasic article is a WP:DAB that includes "Phase (pharmacology)". Phase (pharmacology) was a redirect to this article. I fixed that to be a redirect to the Phases section of this article.

Unfortunately, the original sentence would not make sense if I were to wikilink it as "biphasic" appears to be an entirely different pharmacology process than the three phase breakdown documented here. It's possible that Phase (pharmacology) should be filled out to document both the three-phase, biphasic, and other similar pharmacology processes. --Marc Kupper|talk 21:58, 16 October 2015 (UTC)

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endogenous toxins chapter

I do not agree with the statement "The detoxification of endogenous reactive metabolites such as peroxides and reactive aldehydes often cannot be achieved by the system described above.".

As described in the paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3802536/

it is clear that reactive aldheydes deriving from endogenous lipid peroxides are processed by the xenobiotic detoxification. I would consequently change the chapter as follow:

The detoxification of endogenous reactive metabolites such as peroxides and reactive aldehydes can be achieved by the system described above However, it is possible for enzymatic systems to utilize specific molecular recognition to recognize and remove them. The similarity of these molecules to useful metabolites therefore means that different detoxification enzymes are usually required for the metabolism of each group of endogenous toxins. Examples of these specific detoxification systems are the glyoxalase system, which acts to dispose of the reactive aldehyde methylglyoxal, and the various antioxidant systems that remove reactive oxygen species.

Thanks for the attention — Preceding unsigned comment added by 2001:861:30C1:AC80:A465:F33E:FAF3:EBE6 (talk) 13:01, 23 November 2018 (UTC)