Cyclin E1

CCNE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W98
Identifiers
Aliases	CCNE1, CCNE, pcyclin E1
External IDs	OMIM: 123837; MGI: 88316; HomoloGene: 14452; GeneCards: CCNE1; OMA:CCNE1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q12 Start 29,811,991 bp End 29,824,312 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 25.35 cM Start 37,797,409 bp End 37,806,959 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte placenta testicle decidua bone marrow left testis right testis amniotic fluid gingival epithelium mucosa of transverse colon Top expressed in embryo epiblast morula condyle fossa internal carotid artery fetal liver hematopoietic progenitor cell primitive streak embryo mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding androgen receptor binding protein kinase binding cyclin-dependent protein serine/threonine kinase activity protein kinase activity Cellular component cytosol cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus cyclin E1-CDK2 complex cytoplasm centrosome Biological process androgen receptor signaling pathway Wnt signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of cell cycle cell division positive regulation of transcription, DNA-templated protein phosphorylation DNA replication initiation cell cycle regulation of protein kinase activity negative regulation of transcription by RNA polymerase II telomere maintenance homologous chromosome pairing at meiosis chromosome organization involved in meiotic cell cycle G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle positive regulation of G1/S transition of mitotic cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 898 12447 Ensembl ENSG00000105173 ENSMUSG00000002068 UniProt P24864 Q61457 RefSeq (mRNA) NM_001238 NM_057182 NM_001322259 NM_001322261 NM_001322262 NM_007633 RefSeq (protein) NP_001229 NP_001309188 NP_001309190 NP_001309191 NP_001309188.1 NP_001309190.1 NP_031659 Location (UCSC) Chr 19: 29.81 – 29.82 Mb Chr 7: 37.8 – 37.81 Mb PubMed search
Wikidata
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G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

Interactions

Cyclin E1 has been shown to interact with:

• CDC25A,
• CDKN1B,
• CUL3
• Cdk1,
• Cyclin-dependent kinase 2,
• HERC5,
• P21,
• Retinoblastoma-like protein 2, and
• SMARCA4.

See also

• Cyclin E

Further reading

• Akita H (2003). "[Prognostic importance of altered expression of cell cycle regulators in lung cancer]". Nippon Rinsho. 60. Suppl 5: 267–71. PMID 12101670.
• Mazumder S, DuPree EL, Almasan A (2004). "A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy". Current cancer drug targets. 4 (1): 65–75. doi:10.2174/1568009043481669. PMC 1307511. PMID 14965268.
• Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins". Cell. 70 (6): 993–1006. doi:10.1016/0092-8674(92)90249-C. PMID 1388095.
• Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. doi:10.1126/science.1388288. PMID 1388288.
• Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family". Cell. 66 (6): 1217–28. doi:10.1016/0092-8674(91)90044-Y. PMID 1833068.
• Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
• Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995). "Human cyclin E, a nuclear protein essential for the G1-to-S phase transition". Mol. Cell. Biol. 15 (5): 2612–24. PMC 230491. PMID 7739542.
• Sewing A, Rönicke V, Bürger C, Funk M, Müller R (1994). "Alternative splicing of human cyclin E.". J. Cell. Sci. 107. ( Pt 2): 581–8. PMID 8207080.
• Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". J. Virol. 67 (12): 7641–7. PMC 238233. PMID 8230483.
• Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
• Xu X, Burke SP (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ohtani K, DeGregori J, Nevins JR (1996). "Regulation of the cyclin E gene by transcription factor E2F1". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12146–50. doi:10.1073/pnas.92.26.12146. PMC 40313. PMID 8618861.
• Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein". Oncogene. 12 (6): 1173–80. PMID 8649818.
• Poon RY, Jiang W, Toyoshima H, Hunter T (1996). "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage". J. Biol. Chem. 271 (22): 13283–91. doi:10.1074/jbc.271.22.13283. PMID 8662825.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996). "Cyclin-binding motifs are essential for the function of p21CIP1". Mol. Cell. Biol. 16 (9): 4673–82. PMC 231467. PMID 8756624.
• Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.
• Won KA, Reed SI (1996). "Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E." EMBO J. 15 (16): 4182–93. PMC 452142. PMID 8861947.
• Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C (1997). "Activation of human B-MYB by cyclins". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 532–6. doi:10.1073/pnas.94.2.532. PMC 19547. PMID 9012818.
• Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R (1997). "Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation". Nucleic Acids Res. 25 (11): 2098–105. doi:10.1093/nar/25.11.2098. PMC 146711. PMID 9153308.