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Cells associated with rheumatic heart disease From Wikipedia, the free encyclopedia
In pathology, Anitschkow (or Anichkov[1]) cells are often cells associated with rheumatic heart disease.[2] Anitschkow cells are enlarged macrophages found within granulomas (called Aschoff bodies) associated with the disease.[2]
The cells are also called caterpillar cells, as they have an ovoid nucleus and chromatin that is condensed toward the center of the nucleus in a wavy rod-like pattern that to some resembles a caterpillar.[2] Larger Anitschkow cells may coalesce to form multinucleated Aschoff giant cells.[2] Anitschkow cells were named after the Russian pathologist Nikolay Anichkov.[3]
Squamous epithelial cells with nuclear changes resembling Anitschkow cells have also been observed in recurrent aphthous stomatitis, iron deficiency anemia, children receiving chemotherapy, as well as in healthy individuals.[4][5]
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