5-HT1F receptor

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.^[5]^[6]^[7]^[8]^[9]

Quick Facts HTR1F, Identifiers ...

HTR1F

Identifiers

Aliases

HTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F receptor, 5-hydroxytryptamine receptor 1F

External IDs

OMIM: 182134; MGI: 99842; HomoloGene: 37361; GeneCards: HTR1F; OMA:HTR1F - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p11.2-p11.1	Start	87,792,706 bp^[1]
Band	3p11.2-p11.1	End	87,993,839 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 C1.3\|16 37.1 cM	Start	64,745,092 bp^[2]
Band	16 C1.3\|16 37.1 cM	End	64,926,217 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

islet of Langerhans

Achilles tendon

gonad

prefrontal cortex

smooth muscle tissue

subcutaneous adipose tissue

primary visual cortex

cervix

mononuclear cell

Top expressed in

lumbar spinal ganglion

paraventricular nucleus of thalamus

ventral nucleus of lateral geniculate body

subthalamus

ventral nuclear group

multiform layer of neocortex

lateral preoptic nucleus

ventral lateral nucleus

internal pyramidal layer of neocortex

thalamic reticular nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity serotonin binding G protein-coupled serotonin receptor activity neurotransmitter receptor activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane dendrite
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway signal transduction chemical synaptic transmission G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3355


15557

Ensembl


ENSG00000179097


ENSMUSG00000050783

UniProt


P30939


Q02284

RefSeq (mRNA)


NM_000866 NM_001322208 NM_001322209 NM_001322210


NM_008310

RefSeq (protein)


NP_000857 NP_001309137 NP_001309138 NP_001309139


NP_032336

Location (UCSC)

Chr 3: 87.79 – 87.99 Mb

Chr 16: 64.75 – 64.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

9 Sources

Agonists

5-n-Butyryloxy-DMT:^[10] >60-fold selectivity versus 5-HT_1E receptor
BRL-54443 - mixed 5-HT_1E/1F agonist
Eletriptan - mixed 5-HT_{1B/1D/1E/1F/2B/7} agonist
LY-334,370^[11] - as well as related benzamides^[12]
LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
Naratriptan - mixed 5-HT_1B/1D/1F agonist
Lasmiditan - selective 5-HT_1F agonist, a first-in-class ditan molecule

3 Sources

Antagonists

MLS000756415^[13]

1 Sources

References

[1]
GRCh38: Ensembl release 89: ENSG00000179097 – Ensembl, May 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000050783 – Ensembl, May 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
"Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
[6]
Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.
[7]
Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.
[8]
Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
[9]
Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
[10]
Klein MT, Dukat M, Glennon RA, Teitler M (Jun 2011). "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860–7. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162.
[11]
Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (Mar 2005). "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. S2CID 2230855.
[12]
Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (Dec 2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.
[13]
PudChem: MLS000756415

External links

"5-HT_1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Human HTR1F genome location and HTR1F gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

Wikiwand in your browser!

Seamless Wikipedia browsing. On steroids.

Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.

Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.

Wikiwand for Chrome

Wikiwand for Edge

Wikiwand for Firefox

Agonists

Antagonists

See also

References

Further reading

External links

Wikiwand in your browser!