Janus kinase 1

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.^[5] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.^[6] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.^[7]

Quick Facts JAK1, Available structures ...

JAK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
Identifiers
Aliases	JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
External IDs	OMIM: 147795; MGI: 96628; HomoloGene: 1678; GeneCards: JAK1; OMA:JAK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 64,833,229 bp[1] End 65,067,754 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C6|4 46.19 cM Start 101,152,367 bp[2] End 101,265,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell skin of hip Achilles tendon epithelium of nasopharynx lymph node cartilage tissue superficial temporal artery skin of thigh parietal pleura glutes Top expressed in tibiofemoral joint gastrula lymph node triceps brachii muscle granulocyte mesenteric lymph nodes ankle sternocleidomastoid muscle blood temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity CCR5 chemokine receptor binding growth hormone receptor binding metal ion binding kinase activity protein binding protein tyrosine kinase activity protein phosphatase binding signaling receptor binding ATP binding ubiquitin protein ligase binding non-membrane spanning protein tyrosine kinase activity Cellular component cytoplasm cytosol membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane cytoskeleton endomembrane system nucleus endosome Biological process cell differentiation intracellular signal transduction phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway interferon-gamma-mediated signaling pathway response to antibiotic MAPK cascade positive regulation of sprouting angiogenesis protein phosphorylation regulation of type I interferon-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway regulation of cell population proliferation type I interferon signaling pathway interleukin-2-mediated signaling pathway peptidyl-tyrosine autophosphorylation protein autophosphorylation cell migration innate immune response interleukin-12-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of molecular function peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway interleukin-21-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3716 16451 Ensembl ENSG00000162434 ENSMUSG00000028530 UniProt P23458 P52332 RefSeq (mRNA) NM_002227 NM_001320923 NM_001321852 NM_001321853 NM_001321854 NM_001321855 NM_001321856 NM_001321857 NM_146145 NM_013567 RefSeq (protein) NP_001307852 NP_001308781 NP_001308782 NP_001308783 NP_001308784 NP_001308785 NP_001308786 NP_002218 n/a Location (UCSC) Chr 1: 64.83 – 65.07 Mb Chr 4: 101.15 – 101.27 Mb PubMed search [3] [4]
Wikidata
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