TTF2

TTF2
Identifiers
Aliases	TTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2
External IDs	OMIM: 604718; MGI: 1921294; HomoloGene: 37826; GeneCards: TTF2; OMA:TTF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,107,453 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,969,663 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; epithelium of colon; ; Achilles tendon; ; bone marrow cells; ; gonad; ; rectum; ; epithelium of nasopharynx; ; appendix; ; mucosa of esophagus; ; testicle;
	Top expressed in
	hand; ; primitive streak; ; medullary collecting duct; ; epiblast; ; otic vesicle; ; mandibular prominence; ; maxillary prominence; ; hair follicle; ; endothelial cell of lymphatic vessel; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; zinc ion binding; protein binding; ATP binding; helicase activity; hydrolase activity;
Cellular component	spliceosomal complex; transcription elongation factor complex; nucleus; cytoplasm; cytosol;
Biological process	DNA-templated transcription, termination; termination of RNA polymerase II transcription; mRNA processing; regulation of transcription, DNA-templated; RNA splicing; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	8458
	74044
	ENSG00000116830
	ENSMUSG00000033222
	Q9UNY4
	Q5NC05
	NM_003594
	NM_001013026
	NP_003585
	NP_001013044
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.^[5]^[6]

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This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.^[6]

TTF2 has been shown to interact with CDC5L.^[7]

[1]
GRCh38: Ensembl release 89: ENSG00000116830 – Ensembl, May 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000033222 – Ensembl, May 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.
[6]
"Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
[7]
Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

Girdham CH, Glover DM (October 1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes & Development. 5 (10): 1786–99. doi:10.1101/gad.5.10.1786. PMID 1916263.
Hara R, Selby CP, Liu M, Price DH, Sancar A (August 1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". The Journal of Biological Chemistry. 274 (35): 24779–86. doi:10.1074/jbc.274.35.24779. PMID 10455150.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Jiang Y, Liu M, Spencer CA, Price DH (May 2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Molecular Cell. 14 (3): 375–85. doi:10.1016/S1097-2765(04)00234-5. PMID 15125840.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Jiang Y, Price DH (September 2004). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle. 3 (9): 1151–3. doi:10.4161/cc.3.9.1151. PMID 15467445.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000116830 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000033222 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9748214-5] [5]
Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.

[entrez-6] [6]
"Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".

[pmid12927788-7] [7]
Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

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