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First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.
- Chabala, Chishala;
- Jacobs, Tom;
- Moraleda, Cinta;
- Ndaferankhande, John;
- Mumbiro, Vivian;
- Passanduca, Alfeu;
- Namuziya, Natasha;
- Nalwanga, Damalie;
- Musiime, Victor;
- Ballesteros, Alvaro;
- Domínguez-Rodríguez, Sara;
- Chitsamatanga, Moses;
- Cassia, Uneisse;
- Nduna, Bwendo;
- Bramugy, Justina;
- Sacarlal, Jahit;
- Madrid, Lola;
- Nathoo, Kusum;
- Colbers, Angela;
- Burger, David;
- Mulenga, Veronica;
- Buck, William;
- Mujuru, Hilda;
- Te Brake, Lindsey;
- Rojo, Pablo;
- Tagarro, Alfredo;
- Aarnoutse, Rob
- et al.
Published Web Location
https://doi.org/10.1093/jpids/piad088Abstract
Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.
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