Type 1 diabetes mellitus affects 8.5 million people globally and is characterized by autoimmune destruction of pancreatic β cells. This Review discusses cell replacement therapies for T1DM and outlines the challenges and future directions

This Review outlines the screening, enrolment and recruitment challenges in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. The key findings related to the first primary end point are discussed, and future directions of study are highlighted.

This Review outlines the complex actions of metformin in metabolic regulation, providing a plausible basis for its benefits in the management of gestational diabetes mellitus. The authors also critically evaluate the safety profile of metformin use during pregnancy in patients with gestational diabetes mellitus.

Continuous glucose monitoring (CGM) is an effective tool in the management of diabetes mellitus. This Perspective discusses the potential benefits of widespread adoption of CGM in people with type 2 diabetes mellitus at different stages of disease progression and treatment intensification.

Although science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely remained static, which affects the integrity and impact of articles. At the 2023 Danish Diabetes and Endocrine Academy Postdoc Summit, we identified five aspects of this process that need attention to enable reform.

Liothyronine treatment for some patients with hypothyroidism has preoccupied academics, clinicians and patients for decades, and is a controversial topic in thyroidology. Persistent symptoms are at the heart of this discourse and, contrary to scientific evidence, liothyronine use is increasingly common. Aetiologies and interventions beyond thyroid dysregulation and pharmacological approaches must be pursued.