File:Ubiquitin-Accumulation-on-Disease-Associated-Protein-Aggregates-Is-Correlated-with-Nuclear-pone.0169054.s006.ogv
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[edit]DescriptionUbiquitin-Accumulation-on-Disease-Associated-Protein-Aggregates-Is-Correlated-with-Nuclear-pone.0169054.s006.ogv |
English: Ubiquitin accumulates on aggregates after they form and is depleted from the nucleus. Cells stably expressing YFP-Ubi were transfected with Htt-Q91-Cherry and imaged every six minutes. Left panel is Htt-Q91-Cherry and right panel ubiquitin. T = 0 was arbitrarily chosen at three frames before aggregation of Htt-Q91-Cherry in the lower cell. Initially ubiquitin is absent from the aggregate and it starts to accumulate within about one hour. By the end of the movie the level of ubiquitin in the nucleus is considerably reduced and is comparable to the level of ubiquitin in the cytoplasm. |
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Source | S3 Mov from Ben Yehuda A, Risheq M, Novoplansky O, Bersuker K, Kopito R, Goldberg M, Brandeis M (2017). "Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response". PLOS ONE. DOI:10.1371/journal.pone.0169054. PMID 28052107. PMC: 5215683. | ||
Author | Ben Yehuda A, Risheq M, Novoplansky O, Bersuker K, Kopito R, Goldberg M, Brandeis M | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current | 01:36, 31 January 2017 | 12 s, 321 × 642 (2 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Ubiquitin accumulates on aggregates after they form and is depleted from the nucleus. |
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Author | Ben Yehuda A, Risheq M, Novoplansky O, Bersuker K, Kopito R, Goldberg M, Brandeis M |
Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Cells stably expressing YFP-Ubi were transfected with Htt-Q91-Cherry and imaged every six minutes. Left panel is Htt-Q91-Cherry and right panel ubiquitin. T |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2017-01-04 |