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Authors: Liu, Xiaomei | Yu, Haitao | Shi, Zhenchuan | Guo, Rong | Liu, Yulei

Article Type: Research Article

Abstract: Research on the relationship between thermal and current density relates the design and application of the electrical machine, which is important in the process of improving motors’ efficiency and working capacity. In this article, an electromagnetic-thermal (EM-thermal) coupled-field analysis and fitting method are adopted to research the relationship among current density, recovery time and duration factor of a permanent magnet synchronous linear motor (PMSLM), and the longitudinal temperature characteristics are analyzed, the simulation results are verified by the experiment. The relationship makes it easier for designers to maximize the torque/power rating by increasing the winding current density within the limit of …temperature and provides a basis for the design and choice of PMLSM under different working conditions. Show more

Keywords: Permanent magnet linear motor, current density, electromagnetic-thermal coupled-field, recovery time, cyclic duration

DOI: 10.3233/JAE-190006

Citation: International Journal of Applied Electromagnetics and Mechanics, vol. 61, no. 4, pp. 477-490, 2019

Authors: Guo, Rong | Yu, Haitao | Wang, Yao | Chen, Hao | Liu, Xiaomei | Xia, Tao

Article Type: Research Article

Abstract: Permanent magnet synchronous linear motors (PMSLMs) have been widely used in industry applications due to their outstanding dynamic characteristics and improved servo-capability. However, the detent force of PMSLM is an inevitable problem, which causes vibration and affects the positional accuracy of the machine. An improved PMSLM structure with arc-teeth and inner-ladder end teeth (AIL-teeth) is proposed in this study to reduce detent force. This structure is advantageous because it not only reduces detent force but also keeps motor size constant. First, the parameters that affect detent force are confirmed using Fourier analysis method. Second, a hybrid optimization method is adopted …to obtain the structural parameters of the AIL-teeth PMSLM. The hybrid optimization method is based on the flux-tube and Taguchi methods. The optimal structural parameters of the AIL-teeth PMSLM are determined using the optimization method. Finally, two PMSLMs with traditional and improved structures are contrasted by finite-element analysis (FEA) method and experimental verification, results show that the improved AIL-teeth PMSLM can reduce detent force effectively with the least sacrifice of electromagnetic performance. Show more

Keywords: Detent force minimizes, AIL-teeth PMSLM, flux-tube method, Taguchi method, FEA method

DOI: 10.3233/JAE-180047

Citation: International Journal of Applied Electromagnetics and Mechanics, vol. 58, no. 4, pp. 513-529, 2018

Authors: Liu, Yu | Yu, Haitao | Zeng, Bin | Gou, Xin | Ren, Ke | Yuan, Fangchao

Article Type: Research Article

Abstract: BACKGROUND: MicroRNAs have been proven to be key molecules in human malignancy. However, to our knowledge, there is no study reporting miR-383-5p expression level and the role it plays in bladder cancer (BC). METHODS: We identified miR-383-5p to be one of the tumor-suppressing genes through using data from The Cancer Genome Atlas (TCGA) and GEO database. We evaluate the expression and activity of miR-383-5p in both BC tissue and cell lines. The impacts of miR-383-5p on proliferative, migratory ability and apoptotic rate in BC cell were evaluated by utilizing CCK-8 kits, flow cytometry, and Transwell assays. qRT-PCR, western blot, and …luciferase reporter assays have been adopted to investigate the underlying mechanisms. In vivo tumorigenicity testing was conducted to determine the impact of miR-383-5p on BC cellular proliferative capacity. RESULTS: Reduced miR-383-5p expression has been determined in BC tissue than in normal bladder tissue. Furthermore, BC cell proliferative, migratory ability was inhibited while apoptosis enhanced in vitro and in vivo by miR-383-5p up-regulation. In vitro and in vivo , silencing miR-383-5p considerably improved the growth and invasive capacity of cell, while decreased the apoptotic rates of BC cells. CONCLUSION: miR-383-5p plays its role as a tumor-suppressing gene by suppressing the PI3K/AKT signaling, hence preventing the development of BC. Show more

Keywords: miR-383-5p, PI3KR1, AKT, bladder cancer

DOI: 10.3233/CBM-220379

Citation: Cancer Biomarkers, vol. 37, no. 2, pp. 121-131, 2023

Authors: Pang, Yuyi | Yu, Haitao | Wang, Yao | Che, Zhiyuan | Ali, Murad | Ye, Zhicheng

Article Type: Research Article

Abstract: A novel control strategy based on finite time control and super-twisting observer is proposed to improve the control performance and robustness for permanent magnet synchronous linear motor (PMSLM) drive system. First of all, the velocity-current single loop control which called non-cascade structure control is proposed by the finite time control, then the response velocity of the PMSLM drive system can be improved. Secondly, to improve the disturbance rejection performance, a super-twisting observer is designed to feedforward the load. Furthermore, the strictly convergence of the proposed control strategy is implemented. Finally, comparative simulations and experiments are designed on PI control, sliding …mode control, and the proposed control method. Results demonstrate that the proposed method has better robustness and control performance. Show more

Keywords: Permanent magnet synchronous linear motor, non-cascaded structure, finite-time control, super-twisting observer

DOI: 10.3233/JAE-220200

Citation: International Journal of Applied Electromagnetics and Mechanics, vol. 73, no. 3, pp. 175-190, 2023

Authors: Li, Shuyan | Sun, Yan | Qi, Xiaodan | Shi, Yan | Gao, Han | Wu, Qi | Liu, Xiucai | Yu, Haitao | Zhang, Chunjing

Article Type: Research Article

Abstract: In recent years, diabetes and its associated complications have become a major public health concern. The cardiovascular risk increases significantly in diabetes patients. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The subsequent generation of reactive oxygen species (ROS) and accompanying oxidative stress are hallmarks of the molecular mechanisms responsible for cardiovascular disease. Protein thiols act as redox-sensitive switches and are believed to be a key element in maintaining the cellular redox balance. The redox state of protein thiols …is regulated by oxidative stress and redox signaling and is important to cellular functions. The potential of the thiol–disulfide oxidoreductase enzymes (thioredoxin and glutaredoxin systems) in defense against oxidative stress has been noted previously. Increasing evidence demonstrates that glutaredoxin 1 (Grx1), a cytosolic enzyme responsible for the catalysis of protein deglutathionylation, plays distinct roles in inflammation and apoptosis by inducing changes in the cellular redox system. This study investigates whether and how Grx1 protects coronary artery vascular endothelial cells against high glucose (HG) induced damage. Results indicate that the activation of eNOS/NO system is regulated by Grx 1 and coupled with inhibition of JNK and NF-κB signaling pathway which could alleviate the oxidative stress and apoptosis damage in coronary arteries endothelial cells induced by HG. Show more

Keywords: Grx 1, diabetes cardiovascular complications, redox homeostasis, eNOS/NO system, redox signaling pathway

DOI: 10.3233/BME-141221

Citation: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3897-3903, 2014

Authors: Xiong, Rui | Li, Binrui | Yu, Haitao | Fan, Tianceng | Yu, Huiling | Yang, Ying | Wang, Jian-Zhi | Pi, Guilin | Yang, Xifei

Article Type: Research Article

Abstract: Background: Anxiety and social withdrawal are highly prevalent among patients with Alzheimer’s disease (AD). However, the neural circuit mechanisms underlying these symptoms remain elusive, and there is a need for effective prevention strategies. Objective: This study aims to elucidate the neural circuitry mechanisms underlying social anxiety in AD. Methods: We utilized 5xFAD mice and conducted a series of experiments including optogenetic manipulation, Tandem Mass Tag-labeled proteome analysis, behavioral assessments, and immunofluorescence staining. Results: In 5xFAD mice, we observed significant amyloid-β (Aβ) accumulation in the anterior part of basolateral amygdala (aBLA). Behaviorally, 6-month-old 5xFAD mice displayed excessive social avoidance during social …interaction. Concurrently, the pathway from aBLA to ventral hippocampal CA1 (vCA1) was significantly activated and exhibited a disorganized firing patterns during social interaction. By optogenetically inhibiting the aBLA-vCA1 pathway, we effectively improved the social ability of 5xFAD mice. In the presence of Aβ accumulation, we identified distinct changes in the protein network within the aBLA. Following one month of administration of Urolithin A (UA), we observed significant restoration of the abnormal protein network within the aBLA. UA treatment also attenuated the disorganized firings of the aBLA-vCA1 pathway, leading to an improvement in social ability. Conclusions: The aBLA-vCA1 circuit is a vulnerable pathway in response to Aβ accumulation during the progression of AD and plays a crucial role in Aβ-induced social anxiety. Targeting the aBLA-vCA1 circuit and UA administration are both effective strategies for improving the Aβ-impaired social ability. Show more

Keywords: Alzheimer’s disease, amyloid-β, anxiety, aBLA-vCA1 circuit, urolithin A

DOI: 10.3233/JAD-240298

Citation: Journal of Alzheimer's Disease, vol. 99, no. 4, pp. 1303-1316, 2024

Authors: Gao, Yang | Liu, Yanchao | Zhang, Yao | Wang, Yuying | Zheng, Jie | Xu, Zhipeng | Yu, Haitao | Jin, Zetao | Yin, Yin | He, Benrong | Sun, Fei | Xiong, Rui | Lei, Huiyang | Jiang, Tao | Liang, Yi | Ke, Dan | Zhao, Shi | Mo, Wen | Li, Yanni | Zhou, Qiuzhi | Wang, Xin | Zheng, Chenghong | Zhang, Huaqiu | Liu, Gongping | Yang, Ying | Wang, Jian-Zhi

Article Type: Research Article

Abstract: Background: Olfactory dysfunction appears prior to cognitive decline, and thus it has been suggested to be an early predictor of Alzheimer’s disease. However, it is currently not known whether and how olfactory threshold test could serve as a quick screening tool for cognitive impairment. Objective: To define olfactory threshold test for screening cognitive impairment in two independent cohorts. Methods: The participants are comprised of two cohorts in China, 1,139 inpatients with type 2 diabetes mellitus (T2DM, Discovery cohort) and 1,236 community-dwelling elderly (Validation cohort). Olfactory and cognitive functions were evaluated by Connecticut Chemosensory Clinical Research Center test and Mini-Mental State …Examination (MMSE), respectively. Regression analyses and receiver operating characteristic (ROC) analyses were carried out to determine the relation and discriminative performance of the olfactory threshold score (OTS) regarding identification of cognition impairment. Results: Regression analysis showed that olfactory deficit (reducing OTS) was correlated with cognitive impairment (reducing MMSE score) in two cohorts. ROC analysis revealed that the OTS could distinguish cognitive impairment from cognitively normal individuals, with mean area under the curve values of 0.71 (0.67, 0.74) and 0.63 (0.60, 0.66), respectively, but it failed to discriminate dementia from mild cognitive impairment. The cut-off point of 3 showed the highest validity for the screening, with the diagnostic accuracy of 73.3% and 69.5%. Conclusion: Reducing OTS is associated with cognitive impairment in T2DM patients and the community-dwelling elderly. Therefore, olfactory threshold test may be used as a readily accessible screening tool for cognitive impairment. Show more

Keywords: Cut-off value, mild cognitive impairment, olfactory function, type 2 diabetes mellitus

DOI: 10.3233/JAD-230023

Citation: Journal of Alzheimer's Disease, vol. 93, no. 1, pp. 169-178, 2023