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Authors: Han, Xia | Du, Chunjuan | Chen, Yinghai | Zhong, Xiaofei | Wang, Feng | Wang, Juan | Liu, Changmin | Li, Mianli | Chen, Shaoshui | Li, Baosheng

Article Type: Research Article

Abstract: BACKGROUND: Lung cancer is the main cancer-related deaths worldwide. In this study, we explored the clinical prognostic significance and functional role of miR-939-3p in lung cancer. METHODS: We analyzed the expression of miR-939-3p in lung cancer tissues and cells by qRT-PCR. The prognostic significance of miR-939-3p was investigated using the Kaplan-Meier survival and Cox regression analyses. The CCK-8 assay was used to determine the role of miR-939-3p in cell proliferation. Transwell assays were used to determine the effects of miR-939-3p on cell migration and invasion abilities. RESULTS: The expression of miR-939-3p was upregulated in cancer tissues and cell lines compared …with adjacent normal tissues and normal cells, respectively. The upregulated miR-939-3p was significantly associated with lymph node metastasis, TNM stage and poor prognosis of lung cancer patients. After the transfection of miR-939 mimic, overexpression of miR-939-3p promoted lung cancer cell proliferation, migration, and invasion. CONCLUSION: These findings suggested that miR-939-3p acts as an oncogene and promotes cell proliferation, migration, and invasion in lung cancer. miR-939-3p may be a potential independent prognostic biomarker in lung cancer. Show more

Keywords: miR-939-3p, lung cancer, prognosis, proliferation, migration, invasion

DOI: 10.3233/CBM-190271

Citation: Cancer Biomarkers, vol. 25, no. 4, pp. 325-332, 2019