CHMP6

CHMP6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2K3W, 3HTU
Dynodwyr
Cyfenwau	CHMP6, VPS20, charged multivesicular body protein 6
Dynodwyr allanol	OMIM: 610901 HomoloGene: 11607 GeneCards: CHMP6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein N-terminus binding; • GO:0001948, GO:0016582 protein binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• ESCRT III complex; • cytosol; • endosome; • bilen; • late endosome membrane; • endosome membrane; • extracellular exosome; • endomembrane system;
Prosesau biolegol	• GO:0019067 viral life cycle; • nucleus organization; • regulation of exosomal secretion; • multivesicular body assembly; • ESCRT III complex assembly; • endosomal transport; • protein transport; • septum digestion after cytokinesis; • mitotic metaphase plate congression; • vacuolar transport; • macroautophagy; • negative regulation of epidermal growth factor-activated receptor activity; • GO:0015915 transport; • GO:1903362 regulation of protein catabolic process; • midbody abscission;
	Sources:Amigo / QuickGO
Orthologau
	79643
	n/a
	ENSG00000176108
	n/a
	Q96FZ7
	n/a
	NM_024591
	n/a
	NP_078867
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHMP6 yw CHMP6 a elwir hefyd yn Charged multivesicular body protein 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHMP6.

VPS20

Llyfryddiaeth

"Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. ". Dev Cell. 2009. PMID 19686684.
"Avian sarcoma virus and human immunodeficiency virus, type 1 use different subsets of ESCRT proteins to facilitate the budding process. ". J Biol Chem. 2008. PMID 18723511.
"The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. ". Biochem J. 2015. PMID 25588614.
"Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. ". Biosci Biotechnol Biochem. 2009. PMID 19270365.
"Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death.". Mol Biol Cell. 2014. PMID 25232011.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CHMP6 - Cronfa NCBI

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[2]