About: Senicapoc

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Senicapoc (ICA-17043) is a Gardos channel blocker. It has been proposed for use in sickle cell anemia. Gardos channel blockers may work in the treatment of sickle cell anemia by blocking the efflux of potassium and water from red blood cells, thereby preventing the dehydration of red blood cells and stopping the polymerization of HbS. The Gardos channel has been identified as KCNN4. The "ICA" is for , which is developing the drug.

Property	Value
dbo:abstract	Senicapoc (ICA-17043) is a Gardos channel blocker. It has been proposed for use in sickle cell anemia. Gardos channel blockers may work in the treatment of sickle cell anemia by blocking the efflux of potassium and water from red blood cells, thereby preventing the dehydration of red blood cells and stopping the polymerization of HbS. The Gardos channel has been identified as KCNN4. The "ICA" is for , which is developing the drug. (en)
dbo:iupacName	2,2-Bis(4-fluorophenyl)-2-phenylacetamide (en)
dbo:thumbnail	wiki-commons:Special:FilePath/Senicapoc.png?width=300
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dbo:wikiPageWikiLink	dbc:Acetamides dbc:Fluoroarenes dbr:KCNN4 dbr:Sickle_cell_anemia dbr:Icagen
dbp:imagefile	Senicapoc.png (en)
dbp:imagesize	200 (xsd:integer)
dbp:pin	22 (xsd:integer)
dbp:verifiedfields	changed (en)
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dct:subject	dbc:Acetamides dbc:Fluoroarenes
gold:hypernym	dbr:Blocker
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Abstraction100002137 yago:Acetamide114711197 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Substance100019613 yago:WikicatAcetamides
rdfs:comment	Senicapoc (ICA-17043) is a Gardos channel blocker. It has been proposed for use in sickle cell anemia. Gardos channel blockers may work in the treatment of sickle cell anemia by blocking the efflux of potassium and water from red blood cells, thereby preventing the dehydration of red blood cells and stopping the polymerization of HbS. The Gardos channel has been identified as KCNN4. The "ICA" is for , which is developing the drug. (en)
rdfs:label	Senicapoc (en)
owl:sameAs	freebase:Senicapoc yago-res:Senicapoc wikidata:Senicapoc http://azb.dbpedia.org/resource/سنیکاپوک dbpedia-fa:Senicapoc dbpedia-sh:Senicapoc dbpedia-sr:Senicapoc https://global.dbpedia.org/id/4uP83
prov:wasDerivedFrom	wikipedia-en:Senicapoc?oldid=1044960013&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Senicapoc.png
foaf:isPrimaryTopicOf	wikipedia-en:Senicapoc
is dbo:wikiPageWikiLink of	dbr:KCNN4 dbr:List_of_drugs:_Se–Sh
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