Issue 8, 2011
From the journal:

Soft Matter

Bubble evolution in acoustic droplet vaporization at physiological temperature via ultra-high speed imaging†

Zheng Zheng Wong,a   Oliver D. Kripfgans,a   Adnan Qamar,a   J. Brian Fowlkesa  and  Joseph L. Bull*a  

* Corresponding authors

a The University of Michigan, Ann Arbor, MI, USA
E-mail: [email protected]

Abstract

Acoustic droplet vaporization in a rigid tube at body temperature was investigated experimentally using an ultra-high speed camera. This study was motivated by gas embolotherapy, a developmental cancer treatment in which gas microbubbles that are selectively formed by acoustically vaporizing liquid droplets in vivo are used to occlude tumor blood flow. The evolution of microbubbles formed by acoustic droplet vaporization was analyzed and a four-stage empirical curve was fit to the growth. Viscous resistance from the tube was shown to dampen oscillations of the microbubbles even though the bubble diameter was smaller than the tube diameter. The results suggest that, for some parameter values, vaporization may still be occurring when the bubble expansion starts and indicate the importance of this in modeling the growth of bubbles formed by acoustic droplet vaporization.

Graphical abstract: Bubble evolution in acoustic droplet vaporization at physiological temperature via ultra-high speed imaging

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Article information

DOI
https://doi.org/10.1039/C1SM00007A
Article type
Paper
Submitted
04 Jan 2011
Accepted
24 Jan 2011
First published
03 Mar 2011

Soft Matter, 2011,7, 4009-4016

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Bubble evolution in acoustic droplet vaporization at physiological temperature via ultra-high speed imaging

Z. Z. Wong, O. D. Kripfgans, A. Qamar, J. B. Fowlkes and J. L. Bull, Soft Matter, 2011, 7, 4009 DOI: 10.1039/C1SM00007A

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