Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device

Li Liu; Gang Jin

doi:10.1117/12.871978

16 February 2011 Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device

Li Liu, Gang Jin

Author Affiliations +

Proceedings Volume 7875, Sensors, Cameras, and Systems for Industrial, Scientific, and Consumer Applications XII; 78750U (2011) https://doi.org/10.1117/12.871978
Event: IS&T/SPIE Electronic Imaging, 2011, San Francisco Airport, California, United States

Abstract

The biosensors with properties of real-time, high throughput and label-free are more and more popular recently, in which the biosensor based on the total internal reflection imaging ellipsometry (TIRIE) is a novel imaging detector for protein interaction processes. In previous work, three techniques are introduced to improve the performance of the biosensor including polarization setting optimization, spectroscopic light source application and low noise CCD detector adoption. In this paper, the effect of the low noise CCD detector technology on the sensitivity and detection limit improvement is analyzed. An obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit is obtained by optimization.

Citation Download Citation

Li Liu and Gang Jin "Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device", Proc. SPIE 7875, Sensors, Cameras, and Systems for Industrial, Scientific, and Consumer Applications XII, 78750U (16 February 2011); https://doi.org/10.1117/12.871978

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