A Genomewide Functional Network for the Laboratory Mouse
Figure 3
Analysis of MAPK pathway predictions based on the integrated functional network.
Predictions were derived by iteratively sampling 10 proteins from the known MAPK pathway and finding the closest 40 neighbors based on network adjacency. The results shown are based on an aggregation of 300 such samplings. Bright blue denotes proteins annotated to the canonical MAPK pathway in KEGG. Many of the newly predicted components, although not annotated in KEGG, are supported in the literature (Table S2) and are colored in red. Predictions without literature support are colored in purple. Linkages predicted to be above 0.5 confidence level by our integrated network are shown.