Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks
Figure 7
Bistable networks without cooperativity.
Of the 45 two-gene networks lacking dimerization, 11 were identified as bistable either directly by advanced deficiency theory analysis or via network ancestry. All the dimer-free bistable networks shown here can be derived from the minimal bistable network bcdh through the addition of reactions from Table 1. Horizontal bars represent purely-repressive TF binding, and arrows indicate TF production from a bound gene (at a non-zero rate that may be either higher or lower than the basal rate). Degradation of the TF monomers is not shown.