General Relationship of Global Topology, Local Dynamics, and Directionality in Large-Scale Brain Networks
Fig 4
Relationships of node degree, amplitude and dPLI in human neuroanatomical networks.
The Stuart-Landau model was simulated on the human anatomical brain network before ((A), (C) and (E)) and after ((B), (D) and (F)) perturbation with preferential disruption of hub nodes. The general relationship of node degree, amplitude and dPLI is also demonstrated in this modeled human brain network. The strong negative correlations between node degree and dPLI in (A) and the strong positive correlation between node degree and amplitude in (C) disappear in the perturbed homogeneous network ((B) and (D)). Average dPLI for each node was calculated by averaging the dPLI values of each node with respect to all other nodes. The anatomical connectivity of different brain regions are presented in (E) and (F) ring plots together with average dPLI value for each region. The nodes are aligned in groups: frontal lobe, central regions (including motor and somatosensory cortex), parietal lobe, occipital lobe, temporal lobe, limbic region, and Insula (Ins). Red arrow in (E) points to left and right precuneus. Color of each node shows the average dPLI values with respect to other nodes, from red (dPLI = 1) to blue (dPLI = -1). Average dPLI for each group is also shown in color. The inset within the ringplot shows connections between nodes, highlighted by darker color if the node has a higher degree of connections. Only the links from hub nodes (node with degree value within top 30%) are colored. In the simulation, the time delay between each node was given proportional to the delay, with propagation speed of 6m/s. The coupling strength S was given as 3. The full names for the cortical regions of the human brain network are available in Gong et al. [47].