High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model
Fig 2
The DMF model reproduces the statistically significant differences in the high-order interactions of redundancy.
A: First, the within age-group average SC matrix was calculated. B: Next, the optimal G value for each group was obtained. C: We simulated brain activity within each group using the average SC and the corresponding optimal Gi, computed the O-information as a function of the interaction order, and separated sets of elements into the dominantly redundant (positive O-information values) and synergistic (negative O-information values). Here, the total redundancy (R) and synergy (S) was obtained as the average O-information over the redundant and synergistic sets, respectively. The p-values of the Wilcoxon rank-sum test are also depicted as a function of the interaction order, after comparing the values in I4 versus the ones obtained from the combination of (I1, I2, and I3). When the value of redundancy (or synergy) survived the false discovery rate (FDR) correction, the diamonds (or circles) were filled.