MiR-132 Suppresses the Migration and Invasion of Lung Cancer Cells via Targeting the EMT Regulator ZEB2
Figure 1
MiR-132 is frequently down-regulated in highly metastatic lung cancer cells and tissue specimens.
(A) The relative mRNA levels of miR-132 were detected by qRT-PCR and normalized against an endogenous control (U6 RNA) in several lung cancer cell lines with distinct metastatic ability. Data are reported as mean ±SD for three independent experiments (**P<0.01, Student’s t- test). (B) qRT-PCR analysis of miR-132 expression in 45 pairs of primary NSCLC tissues and their corresponding lymph node metastases. MiR-132 expression in those two types of tissues was compared by way of Wilcoxon signed-rank test (***P<0.001, Student’s t- test).