MiR-132 Suppresses the Migration and Invasion of Lung Cancer Cells via Targeting the EMT Regulator ZEB2
Figure 2
MiR-132 is able to inhibit the migration and invasion of NSCLC cells in vitro.
(A) The wound healing or was used to detected the migration ability of L9981 and A549 cells, respectively. (B, C) Boyden chamber assay was employed to examine the invasion ability of 95D, L9981, and A549 cells, respectively. The results were from three independent experiments (*P<0.05, **P<0.01, Student’s t- test). The migratory cell number in each group was normalized to the control. Cells were transfected with pcDNA3.1 (NC) or pcDNA3.1-miR-132 (miR-132) constructs, and miR-132 inhibitor (anti-miR-132) or inhibitor control (anti-miR-NC). The migratory A549 cells in lower chambers from one experiment were shown in B.