The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Short Report
Exogenous Recombinant Human IL-12 Augments MHC Class I Antigen Expression on Human Cancer Cells in vitro
Shuji Suzuki, Yasuiki Umezu, Yasuo Saijo, George Satoh, Yoshinao Abe, Ken Satoh, Toshihiro Nukiwa
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Keywords: rhIL-12, MHC class I antigen, cancer cells
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1998 Volume 185 Issue 3 Pages 223-226

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Abstract
We investigated whether expressions of MHC class I and class II antigens relevant to tumor antigen presentation were changed on human tumor cells cultured with or without recombinant human IL-12(rhIL-12). We showed that the expression of MHC class I antigen on UTC-8, 28-1Cl and SBC-3 cells was augmented when these cancer cells were cultured with rhIL-12. The expression of class II antigen was slightly raised on UTC-8 and 28-1Cl cells by rhIL-12, but not enhanced on SBC-3 cells. These results suggest that rhIL-12 may provide possible enhancement of immunologic tumor recognition, and cytotoxic activity of lymphocytes against tumors through the enhanced expression of MHC class I antigen.
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© 1998 Tohoku University Medical Press
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