BAIAP2

Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene.

BAIAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WDZ, 1Y2O, 2YKT, 3RNJ, 4JS0
Identifiers
Aliases	BAIAP2, BAP2, FLAF3, IRSP53, BAI1 associated protein 2, BAR/IMD domain containing adaptor protein 2, WAML
External IDs	OMIM: 605475; MGI: 2137336; HomoloGene: 9697; GeneCards: BAIAP2; OMA:BAIAP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 81,035,122 bp End 81,117,432 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 119,833,589 bp End 119,897,608 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole middle frontal gyrus right frontal lobe skin of abdomen anterior cingulate cortex skin of leg Brodmann area 9 caudate nucleus nucleus accumbens Top expressed in superior frontal gyrus olfactory tubercle dentate gyrus of hippocampal formation granule cell primary visual cortex piriform cortex corneal stroma nucleus accumbens perirhinal cortex entorhinal cortex primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein C-terminus binding protein binding identical protein binding cytoskeletal anchor activity proline-rich region binding cadherin binding involved in cell-cell adhesion transcription coregulator binding scaffold protein binding Cellular component cytosol cell projection postsynaptic density membrane filopodium ruffle dendritic spine secretory granule soma actin cytoskeleton neuron projection extracellular exosome cytoskeleton cytoplasm rough endoplasmic reticulum Golgi apparatus microtubule plasma membrane dendritic shaft neuron projection terminus excitatory synapse synaptic membrane postsynapse neuron projection branch point dendritic spine cytoplasm presynapse nucleoplasm Schaffer collateral - CA1 synapse glutamatergic synapse postsynaptic density, intracellular component presynaptic cytosol postsynaptic cytosol Biological process insulin receptor signaling pathway positive regulation of actin filament polymerization regulation of actin cytoskeleton organization response to bacterium axonogenesis Fc-gamma receptor signaling pathway involved in phagocytosis dendrite development actin filament bundle assembly regulation of synaptic plasticity vascular endothelial growth factor receptor signaling pathway actin crosslink formation regulation of cell shape plasma membrane organization positive regulation of actin cytoskeleton reorganization positive regulation of dendritic spine morphogenesis cell-cell adhesion brain development positive regulation of neuron projection development neuron differentiation protein localization to synapse cellular response to epidermal growth factor stimulus cellular response to L-glutamate positive regulation of excitatory postsynaptic potential modulation of chemical synaptic transmission modification of synaptic structure, modulating synaptic transmission regulation of modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10458 108100 Ensembl ENSG00000175866 ENSMUSG00000025372 UniProt Q9UQB8 Q8BKX1 RefSeq (mRNA) NM_001144888 NM_006340 NM_017450 NM_017451 NM_001037754 NM_001037755 NM_130862 RefSeq (protein) NP_001138360 NP_006331 NP_059344 NP_059345 NP_001032843 NP_001032844 NP_570932 Location (UCSC) Chr 17: 81.04 – 81.12 Mb Chr 11: 119.83 – 119.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function.

Interactions

BAIAP2 has been shown to interact with:

• ATN1,
• CDC42,
• EPS8,
• RAC1,
• SHANK1,
• WASF1, and
• WASF2.

External links

• Human BAIAP2 genome location and BAIAP2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (1999). "Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate". Hum. Mol. Genet. 8 (6): 947–57. doi:10.1093/hmg/8.6.947. PMID 10332026.
• Abbott MA, Wells DG, Fallon JR (1999). "The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses". J. Neurosci. 19 (17): 7300–8. doi:10.1523/JNEUROSCI.19-17-07300.1999. PMC 6782521. PMID 10460236.
• Fujiwara T, Mammoto A, Kim Y, Takai Y (2000). "Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2". Biochem. Biophys. Res. Commun. 271 (3): 626–9. doi:10.1006/bbrc.2000.2671. PMID 10814512.
• Miki H, Yamaguchi H, Suetsugu S, Takenawa T (2001). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813): 732–5. Bibcode:2000Natur.408..732M. doi:10.1038/35047107. PMID 11130076. S2CID 4426046.
• Govind S, Kozma R, Monfries C, et al. (2001). "Cdc42hs Facilitates Cytoskeletal Reorganization and Neurite Outgrowth by Localizing the 58-Kd Insulin Receptor Substrate to Filamentous Actin". J. Cell Biol. 152 (3): 579–94. doi:10.1083/jcb.152.3.579. PMC 2195994. PMID 11157984.
• Krugmann S, Jordens I, Gevaert K, et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. S2CID 11290377.
• Miki H, Takenawa T (2002). "WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac". Biochem. Biophys. Res. Commun. 293 (1): 93–9. doi:10.1016/S0006-291X(02)00218-8. PMID 12054568.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Soltau M, Richter D, Kreienkamp HJ (2003). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591. S2CID 572407.
• Sekerková G, Loomis PA, Changyaleket B, et al. (2003). "Novel Espin Actin-bundling Proteins Are Localized to Purkinje Cell Dendritic Spines and Bind the SH3 Adapter Protein Insulin Receptor Substrate p53". J. Neurosci. 23 (4): 1310–9. doi:10.1523/JNEUROSCI.23-04-01310.2003. PMC 2854510. PMID 12598619.
• Miyahara A, Okamura-Oho Y, Miyashita T, et al. (2003). "Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein". J. Hum. Genet. 48 (8): 410–4. doi:10.1007/s10038-003-0047-x. PMID 12884081.
• Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi:10.1074/jbc.M309408200. PMID 14752106.
• Funato Y, Terabayashi T, Suenaga N, et al. (2004). "IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness". Cancer Res. 64 (15): 5237–44. doi:10.1158/0008-5472.CAN-04-0327. PMID 15289329. S2CID 9844872.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.