Elongation factor for RNA polymerase II 2

Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene.

ELL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5N
Identifiers
Aliases	ELL2, elongation factor for RNA polymerase II 2, MRCCAT1
External IDs	OMIM: 601874; MGI: 2183438; HomoloGene: 8094; GeneCards: ELL2; OMA:ELL2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q15 Start 95,885,098 bp End 95,961,851 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 C1 Start 75,854,876 bp End 75,920,483 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of paranasal sinus cartilage tissue Achilles tendon islet of Langerhans pancreatic epithelial cell gums oral cavity gingival epithelium lower lobe of lung Top expressed in seminal vesicula lacrimal gland parotid gland submandibular gland molar blood epithelium of lens epithelium of stomach human fetus body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus transcription elongation factor complex nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription elongation from RNA polymerase II promoter snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22936 192657 Ensembl ENSG00000118985 ENSMUSG00000001542 UniProt O00472 Q3UKU1 RefSeq (mRNA) NM_012081 NM_138953 RefSeq (protein) NP_036213 NP_620403 Location (UCSC) Chr 5: 95.89 – 95.96 Mb Chr 13: 75.85 – 75.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The encoded protein is a component of the superelongation complex (SEC) and drives immunoglobulin synthesis in plasma cells. Sequence variation in ELL2 has been associated with multiple myeloma and altered immunoglobulin levels.

Further reading

• Martincic K, Alkan SA, Cheatle A, Borghesi L, Milcarek C (October 2009). "Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing". Nat. Immunol. 10 (10): 1102–9. doi:10.1038/ni.1786. PMC 2771556. PMID 19749764.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Liu M, Hsu J, Chan C, Li Z, Zhou Q (May 2012). "The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription". Mol. Cell. 46 (3): 325–34. doi:10.1016/j.molcel.2012.03.007. PMC 3360964. PMID 22483617.
• Mann MC, Strobel S, Fleckenstein B, Kress AK (September 2014). "The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax". Virology. 464–465: 98–110. doi:10.1016/j.virol.2014.06.028. PMID 25058508.
• Park KS, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C (November 2014). "Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response". J. Immunol. 193 (9): 4663–74. doi:10.4049/jimmunol.1401608. PMC 4201982. PMID 25238757.
• Swaminathan B, Thorleifsson G, Jöud M, Ali M, Johnsson E, Ajore R, Sulem P, Halvarsson BM, Eyjolfsson G, Haraldsdottir V, Hultman C, Ingelsson E, Kristinsson SY, Kähler AK, Lenhoff S, Masson G, Mellqvist UH, Månsson R, Nelander S, Olafsson I, Sigurðardottir O, Steingrimsdóttir H, Vangsted A, Vogel U, Waage A, Nahi H, Gudbjartsson DF, Rafnar T, Turesson I, Gullberg U, Stefánsson K, Hansson M, Thorsteinsdóttir U, Nilsson B (May 2015). "Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma". Nat Commun. 6: 7213. Bibcode:2015NatCo...6.7213S. doi:10.1038/ncomms8213. PMC 4455110. PMID 26007630.
• Huang Q, Zhang XW, Ma YS, Lu GX, Xie RT, Yang HQ, Lv ZW, Zhong XM, Liu T, Huang SX, Fu D, Xie C (July 2017). "Up-regulated microRNA-299 corrected with poor prognosis of glioblastoma multiforme patients by targeting ELL2". Jpn. J. Clin. Oncol. 47 (7): 590–596. doi:10.1093/jjco/hyw188. PMID 28531325.
• Alexander LM, Watters J, Reusch JA, Maurin M, Nepon-Sixt BS, Vrzalikova K, Alexandrow MG, Murray PG, Wright KL (November 2017). "Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival". Mol. Immunol. 91: 8–16. doi:10.1016/j.molimm.2017.08.016. PMC 5653440. PMID 28858629.
• Pascal LE, Masoodi KZ, Liu J, Qiu X, Song Q, Wang Y, Zang Y, Yang T, Wang Y, Rigatti LH, Chandran U, Colli LM, Vencio RZ, Lu Y, Zhang J, Wang Z (November 2017). "Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia". J. Endocrinol. 235 (2): 123–136. doi:10.1530/JOE-17-0112. PMC 5679084. PMID 28870994.