Meisel or Meisels is a surname. Notable people with the surname include:
- Dow Ber Meisels (1798–1870), Polish Orthodox rabbi
- Edmund Meisel, German composer
- Elazar Meisels, an American Orthodox rabbi
- Hilde Meisel, (1914–1945), German Resistance fighter and writer
- John Meisel, (born 1923), Canadian political scientist, professor, and scholar
- Mordecai Meisel, (1528—1601), philanthropist and communal leader in Prague
- Samuel J. Meisels (born 1945), American expert on early childhood assessment and child development
- Steven Meisel (fashion photographer) Vogue
- Tamar Meisels, Israeli political theorist
- Wilhelm Meisel, (1891–1974), German admiral during World War II