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Alzheimer's disease

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Alzheimer's disease
SpecialtyNeurology Edit this on Wikidata
Frequency5.05% (Europe)

Alzheimer's disease (AD), also called Alzheimer disease or simply Alzheimer's, is the most common form of dementia. This incurable, degenerative and terminal disease was first described by German psychiatrist Alöis Alzheimer in 1901. Generally it is diagnosed in people over 65 years of age,[1] although the less-prevalent early-onset Alzheimer's can occur much earlier. An estimated 26.6 million people worldwide were afflicted by Alzheimer's in 2006; this number may quadruple by 2050.[2]

Although each sufferer experiences Alzheimer's in unique ways, there are many common symptoms.[3] The earliest observable symptoms are often mistakenly thought to be 'age-related' concerns, or manifestations of stress.[4] The most commonly recognised early symptom is memory loss, such as difficulty in remembering recently learned facts. When a doctor or physician has been notified, and AD is suspected, the diagnosis is usually confirmed with behavioural assessments and cognitive tests, often followed by a brain scan if available.[5] As the disease advances, symptoms include confusion, irritability and aggression, mood swings, language breakdown, long-term memory loss, and the general withdrawal of the sufferer as his senses decline.[4][6] Gradually, minor and major bodily functions are lost, ultimately leading to death.[7] Individual prognosis is difficult to assess, as the duration of the disease varies. AD develops for an indeterminate period of time before becoming fully apparent, and it can progress undiagnosed for years. The mean life expectancy following diagnosis is approximately seven years.[8] Fewer than three percent of individuals live more than fourteen years after diagnosis.[9]

The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain.[10] Currently used treatments offer a small symptomatic benefit; no treatments to delay or halt the progression of the disease are as yet available. As of 2008, more than 500 clinical trials were investigating possible treatments for AD, but it is unknown if any of them will prove successful.[11] Many measures have been suggested for the prevention of Alzheimer's disease, but their value is unproven in slowing the course and reducing the severity of the disease. Mental stimulation, exercise and a balanced diet are often recommended, as both a possible prevention and a sensible way of managing the disease.[12]

Because AD cannot be cured and is degenerative, management of patients is essential. The role of the main caregiver is often taken by the spouse or a close relative.[13] Alzheimer's disease is known for placing a great burden on caregivers; the pressures can be wide-ranging, involving social, psychological, physical and economic elements of the caregiver's life.[14][15][16] In developed countries, AD is one of the most economically costly diseases to society.[17][18]

Characteristics

The disease course is divided into four stages, with a progressive pattern of cognitive and functional impairment.

Predementia

The first symptoms are often mistaken as related to ageing or stress.[4] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfils the clinical criteria for diagnosis of AD.[19] These early symptoms can have an effect on the most complex daily living activities.[20] The most noticeable deficit is memory loss, which shows as a difficulty to remember recently learned facts and an inability to acquire new information.[21][22] Subtle problems with the executive functions of attentiveness, planning, flexibility, and abstract thinking or with impairments in semantic memory (memory of meanings, and concept relationships) can also be symptomatic of the early stages of AD.[23][24] Apathy can be observed at this stage, and remains the most persistent neuropsychiatric symptom throughout the course of the disease.[25][26][27] The preclinical stage of the disease has also been termed mild cognitive impairment,[28] but there is still debate on whether this term corresponds to a different diagnostic entity by itself or just a first step of the disease.[29]

Early dementia

In people with AD, the increasing impairment of learning and memory will lead to a definitive diagnosis. In a small proportion of them, difficulties with language, executive functions, recognition of perceptions (agnosia) or execution of movements (apraxia) will be more prominent than memory problems.[30] AD does not affect all memory capacities equally. Older memories of the person's life (episodic memory), facts learned (semantic memory), and implicit memory (the memory of the body on how to do things, such as using a fork to eat) are affected to a much lesser degree than the capacities needed to learn new facts or make new memories.[31][32] Language problems are mainly characterised by a shrinking vocabulary and decreased word fluency, which lead to a general impoverishment of oral and written language. The person with Alzheimer is usually capable of adequately communicating basic ideas.[33][34][35] While performing fine motor tasks such as writing, drawing or dressing, certain movement coordination and planification difficulties (apraxia) may be present, which may appear as clumsiness.[36] As the disease progresses, they can still perform tasks independently, but may need assistance or supervision with the most cognitively demanding activities.[30]

Moderate dementia

People with AD can usually care for themselves during the early stages of the disease, but progressive deterioration hinders independence.[30] Speech difficulties become evident due to an inability to recall vocabulary which leads to frequent incorrect word substitutions (paraphasias). Reading and writing skills are also progressively lost.[33][37] Complex motor sequences become less coordinated as time passes, reducing the ability to perform most normal daily living activities.[38] During this phase, memory problems worsen, and the person may not recognise close relatives.[39] Long-term memory, which was previously left intact, becomes impaired.[40] At this stage, behaviour changes are more prevalent. Common neuropsychiatric manifestations are wandering, sundowning, irritability and labile affect, leading to crying, outbursts of unpremeditated aggression or resistiveness when cared. Approximately 30% of the patients also develop illusionary misidentifications and other delusional symptoms.[41][25] Urinary incontinence can develop.[42] These symptoms create stress for relatives and caretakers, which can be reduced by moving the person from home care to other long-term care facilities.[30][43]

Advanced dementia

During this last stage of AD, the patient is completely dependent upon caregivers. Language is reduced to simple phrases or even single words, eventually leading to complete loss of speech.[33] Despite the loss of verbal language abilities, they can receive and return emotional signals.[44] Although aggressiveness can still be present, extreme apathy and exhaustion are much more common results.[30] Patients will ultimately not be able to perform even the most simple tasks without assistance. Muscle mass and mobility will deteriorate to the point where they are bedridden,[45] and they will also lose the ability to feed themselves.[46] Death occurs from some external factor such as pressure ulcers or pneumonia, and not from the disease itself.[47][48]

Pathophysiology

Main article: Biochemistry of Alzheimer's disease
Histopathologic image of senile plaques seen in the cerebral cortex of a person with Alzheimer's disease of presenile onset. Silver impregnation.

Neuropathology

Alzheimer's disease is characterised by loss of neurons and synapses in the cerebral cortex and certain subcortical regions. This loss results in gross atrophy of the affected regions, including degeneration in the temporal lobe and parietal lobe, and parts of the frontal cortex and cingulate gyrus.[49]

Both amyloid plaques and neurofibrillary tangles are clearly visible by microscopy in brains of those afflicted by AD.[10] Plaques are dense, mostly insoluble deposits of amyloid-beta protein and cellular material outside and around neurons. They continue to grow into insoluble twisted fibres within the nerve cell, often called tangles. Although many older individuals develop some plaques and tangles as a consequence of ageing, the brains of AD patients have a greater number of them in specific brain regions such as the temporal lobe.[50]

Biochemistry

Enzymes act on the APP (amyloid precursor protein) and cut it into fragments. The beta-amyloid fragment is crucial in the formation of senile plaques in AD.

Alzheimer's disease has been identified as a protein misfolding disease (proteopathy), due to the accumulation of abnormally folded A-beta and tau proteins in the brain.[51] Plaques are made up of small peptides, 39–43 amino acids in length, called beta-amyloid (also written as A-beta or Aβ). Beta-amyloid is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates through the neuron's membrane. APP is critical to neuron growth, survival and post-injury repair.[52][53] In Alzheimer's disease, an unknown process causes APP to be divided into smaller fragments by enzymes through proteolysis.[54] One of these fragments is fibrils of beta-amyloid, which form clumps that deposit outside neurons in dense formations known as senile plaques.[10][55]

In Alzheimer's disease, changes in tau protein lead to the disintegration of microtubules in brain cells.

AD is also considered a tauopathy due to abnormal aggregation of the tau protein. Healthy neurons have a cytoskeleton, an internal support structure partly made up of structures called microtubules. These microtubules act like tracks, guiding nutrients and molecules from the body of the cell to the ends of the axon and back. A protein called tau stabilises the microtubules when phosphorylated, and is therefore called a microtubule-associated protein. In AD, tau undergoes chemical changes, becoming hyperphosphorylated; it then begins to pair with other threads, creating neurofibrillary tangles and disintegrating the neuron's transport system.[56]

Disease mechanism

Exactly how production and aggregation of the beta amyloid peptide plays a key role in AD has not been elucidated.[57] The traditional formulation of the amyloid hypothesis points to the accumulation of beta amyloid peptides as the central event triggering neuron degeneration. Accumulation of aggregated amyloid fibrils, which are believed to be the toxic form of the protein responsible for disrupting the cell's calcium ion homeostasis, induces programmed cell death (apoptosis).[58] It is also known that Aβ selectively builds up in the mitochondria in the cells of Alzheimer's-affected brains, and it also inhibits certain enzyme functions and the utilisation of glucose by neurons.[59]

Various inflammatory processes and cytokines may also have a role in the pathology of Alzheimer's disease. Inflammation is a general marker of tissue damage in any disease, and may be either secondary to tissue damage in AD or a marker of an immunological response.[60]

Genetics

While the rare, early-onset form of Alzheimer's disease is mainly explained by mutations in three genes, the most common form has yet to be explained by a purely genetic model. The APOE gene is the strongest genetic risk factor for Alzheimer's discovered so far, but its presence is far from explaining all occurrences of the disease.[61]

Less than 10% of AD cases occurring before 60 years of age are due to autosomal dominant (familial) mutations, which represent less than 0.01% of all cases.[61][62][63] These mutations have been discovered in three different genes: amyloid precursor protein (APP) and presenilins 1 and 2.[61] Most mutations in the APP and presenilin genes increase the production of a small protein called Abeta42, which is the main component of senile plaques.[64]

Most cases of Alzheimer's disease do not exhibit familial inheritance but genes may act as risk factors. The best known genetic risk factor is the inheritance of the ε4 allele of the apolipoprotein E (APOE). This gene is regarded as a risk factor for development of up to 50% of late-onset sporadic Alzheimer's.[65] Genetic experts agree that other genes act as risk factors or have protective effects that influence the development of late onset Alzheimer's disease.[61] Over 400 genes have been tested for association with late-onset sporadic AD.[66] An example is a gene variation of reelin which may contribute to Alzheimer's risk in women.[67]

Causes

File:TAU HIGH.JPG
Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein

Three major competing hypotheses exist to explain the cause of the disease. The oldest, on which most currently available drug therapies are based, is the cholinergic hypothesis and suggests that AD is due to reduced synthesis of the neurotransmitter acetylcholine. The cholinergic hypothesis has not maintained widespread support due to the reduced efficacy of medications that treat acetylcholine deficiency, although cholinergic effects have been proposed to initiate large-scale aggregation,[68] leading to generalised neuroinflammation.[49]

The amyloid hypothesis was proposed in 1991;[69] here amyloid beta (Aβ) deposits are postulated to be the causative factor in the disease.[70] It is a compelling theory because the gene for the amyloid beta precursor (APP) is located on chromosome 21, and people with trisomy 21 (Down Syndrome) who thus have an extra gene copy almost universally exhibit AD by 40 years of age.[71][72] Also APOE4, the major genetic risk factor for AD, leads to excess amyloid buildup in the brain before AD symptoms arise. Thus, Aβ deposition precedes clinical AD.[73] Further evidence comes from the finding that transgenic mice, which solely express a mutant human APP gene, develop fibrillar amyloid plaques.[74] An experimental vaccine was found to clear the amyloid plaques, but it did not have any significant effect on dementia.[75]

Deposition of amyloid plaques does not correlate well with neuron loss.[76] This observation supports the tau hypothesis, the idea that tau protein abnormalities initiate the disease cascade.[70] In this model, hyperphosphorylated tau begins to pair with other threads of tau. Eventually, they form neurofibrillary tangles inside nerve cell bodies.[77] When this occurs, the microtubules disintegrate, collapsing the neuron's transport system. This may result first in malfunctions in biochemical communication between neurons and later in the death of the cells.[78]

Diagnosis

PET scan of the brain of a person with AD showing a loss of function in the temporal lobe

Alzheimer's disease is usually diagnosed clinically from the patient history, collateral history from relatives, and clinical observations, based on the presence of characteristic neurological and neuropsychological features and the absence of alternative conditions.[79][80] Advanced medical imaging with computed tomography (CT) or magnetic resonance imaging (MRI), and with single photon emission computed tomography (SPECT) or positron emission tomography (PET) can be used to help exclude other cerebral pathology or subtype of dementia .[81] Assessment of intellectual functioning including memory testing can further characterise the state of the disease.[4] Medical organisations have created diagnostic criteria to ease and standardise the diagnostic process for practicing physicians. Sometimes the diagnosis can be confirmed or made at post-mortem when brain material is available and can be examined histologically.[82]

Diagnostic criteria

The National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (now known as the Alzheimer's Association) established the most commonly used diagnostic criteria for Alzheimer's disease.[83] These criteria require that the presence of cognitive impairment, and a suspected dementia syndrome, be confirmed by neuropsychological testing for a clinical diagnosis of possible or probable AD. A histopathologic confirmation including a microscopic examination of brain tissue is required for a definitive diagnosis. Good statistical reliability and validity have been shown between the diagnostic criteria and definitive histopathological confirmation.[84] Eight cognitive domains are most commonly impaired in AD—memory, language, perceptual skills, attention, constructive abilities, orientation, problem solving and functional abilities. These domains are equivalent to the NINCDS-ADRDA Alzheimer's Criteria as listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) published by the American Psychiatric Association.[85][86]

Diagnostic tools

Neuropsychological screening tests can help in the diagnosis of AD. In them patients have to copy drawings similar to the one shown in the picture, remember words, read or sum.

Neuropsychological screening tests, such as the mini-mental state examination (MMSE), are widely used to evaluate the cognitive impairments needed for diagnosis. More comprehensive tests arrays are necessary for high reliability of results, particularly in the earliest stages of the disease.[87][88] Neurological examination in early AD will usually provide normal results, except for obvious cognitive impairment, which may not differ from standard dementia. Further neurological examinations are crucial in the differential diagnosis of AD and other diseases.[4] Interviews with family members are also utilised in the assessment of the disease. Caregivers can supply important information on the daily living abilities, as well as on the decrease, over time, of the person's mental function.[89] A caregiver's viewpoint is particularly important, since a person with AD is commonly unaware of his own deficits.[90] Many times, families also have difficulties in the detection of initial dementia symptoms and may not communicate accurate information to a physician.[91] Supplemental testing provides extra information on some features of the disease or is used to rule out other diagnoses. Blood tests can identify other causes for dementia than AD[4]—causes which may, in rare cases, be reversible.[92] Psychological tests for depression are employed, since depression can either be concurrent with AD or be the cause of cognitive impairment.[93][94]

When available as a diagnostic tool, SPECT and PET neuroimaging are used to confirm a diagnosis of Alzheimer's in conjunction with evaluations involving mental status examination.[95] The ability of SPECT to differentiate Alzheimer's disease from other possible causes in somebody already known to be suffering from dementia, appears to be superior to attempts to diagnosis by mental testing and history.[96] A new technique known as PiB PET has been developed for directly and clearly imaging beta-amyloid deposits in vivo using a tracer that binds selectively to the Abeta deposits.[97] Another recent objective marker of the disease is the analysis of cerebrospinal fluid for amyloid beta or tau proteins.[98] Both advances have led to the proposal of new diagnostic criteria.[83][4]

Prevention

Intellectual activities such as playing chess or regular social interaction have been linked to a reduced risk of AD in epidemiological studies, although no causal relationship has been found.

Global studies of measures to prevent or delay the onset of AD have had contradictory results, have not proven causal relationships between risk factors and the disease or have been attributed to secondary effects. There appears to be no definitive measures to prevent the onset of AD.[99] Different epidemiological studies have proposed relationships between certain modifiable factors, such as diet, cardiovascular risk, pharmaceutical products, or intellectual activities among others, and a population's likelihood of developing AD. Only further research, including clinical trials, will reveal whether, in fact, these factors can help to prevent AD.[100]

The components of a Mediterranean diet, which include fruit and vegetables, bread, wheat and other cereals, olive oil, fish, and red wine, may all individually or together reduce the risk and course of Alzheimer's disease.[101] Different vitamins such as B12, B3, C or folic acid have appeared to be related to a reduced risk of AD[102] but other studies indicate that they do not have any significant effect on the onset or course of the disease and may have important secondary effects.[103] Curcumin in curry has shown some effectiveness in preventing brain damage in mouse models.[104]

Although cardiovascular risk factors, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with a higher risk of onset and course of AD,[105][106] statins, which are cholesterol lowering drugs, have not been effective in preventing or improving the course of the disease.[107][108] However long-term usage of non-steroidal anti-inflammatory drug (NSAIDs), is associated with a reduced likelihood of developing AD in some individuals.[109] Other pharmaceutical therapies such as female hormone replacement therapy are no longer thought to prevent dementia,[110][111] and a 2007 systematic review concluded that there was inconsistent and unconvincing evidence that ginkgo has any positive effect on cognitive impairment.[112]

Intellectual activities such as playing chess, completing crossword puzzles or regular social interaction may also delay the onset or reduce the severity of Alzheimer's disease.[113][114] Bilingualism is also related to a later onset of Alzheimer's.[115]

Some studies have shown an increased risk of developing AD with occupational exposure to magnetic fields,[116][117] intake of metals, particularly aluminium,[118][119] or exposure to solvents.[120] The quality of some of these studies has been criticised,[121] and other studies have concluded that there is no relationship between these environmental factors and the development of AD.[122][123] [124][125]

Management

There is no cure for Alzheimer's disease; available treatments offer relatively small symptomatic benefit but remain palliative in nature. Current treatments can be divided into pharmaceutical, psychosocial and caregiving.

Pharmaceutical

Three-dimensional molecular model of donepezil, an acetylcholinesterase inhibitor used in the treatment of AD symptoms
Molecular structure of memantine, a medication approved for advanced AD symptoms

Four medications are currently approved by regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) to treat the cognitive manifestations of AD: three are acetylcholinesterase inhibitors and the other is memantine, an NMDA receptor antagonist. No drug has an indication for delaying or halting the progression of the disease.

Reduction in the activity of the cholinergic neurons is a well-known feature of Alzheimer's disease.[126] Acetylcholinesterase inhibitors are employed to reduce the rate at which acetylcholine (ACh) is broken down, thereby increasing the concentration of ACh in the brain and combating the loss of ACh caused by the death of cholinergic neurons.[127] As of 2008, the cholinesterase inhibitors approved for the management of AD symptoms are donepezil (brand name Aricept),[128] galantamine (Razadyne),[129] and rivastigmine (branded as Exelon[130] and Exelon Patch[131]). There is evidence for the efficacy of these medications in mild to moderate Alzheimer’s disease,[132] and some evidence for their use in the advanced stage. Only donepezil is approved for treatment of advanced AD dementia.[133] The use of these drugs in mild cognitive impairment has not shown any effect in a delay of the onset of AD.[134] The most common side effects are nausea and vomiting, both of which are linked to cholinergic excess. These side effects arise in approximately ten to twenty percent of users and are mild to moderate in severity. Less common secondary effects include muscle cramps, decreased heart rate (bradycardia), decreased appetite and weight, and increased gastric acid production.[135] Glutamate is a useful excitatory neurotransmitter of the nervous system, although excessive amounts in the brain can lead to cell death through a process called excitotoxicity which consists of the overstimulation of glutamate receptors. Excitotoxicity occurs not only in Alzheimer's disease, but also in other neurological diseases such as Parkinson's disease and multiple sclerosis.[136] Memantine (brand names Akatinol, Axura, Ebixa/Abixa, Memox and Namenda),[137] is a noncompetitive NMDA receptor antagonist first used as an anti-influenza agent. It acts on the glutamatergic system by blocking NMDA receptors and inhibiting their overstimulation by glutamate.[136] Memantine has been shown to be moderately efficacious in the treatment of moderate to severe Alzheimer’s disease. Its effects in the initial stages of AD are unknown.[138] Reported adverse events with memantine are infrequent and mild, including hallucinations, confusion, dizziness, headache and fatigue.[139] The combination of memantine and donepezil has been shown to be "of statistically significant but clinically marginal effectiveness".[140]

Antipsychotic drugs are modestly useful in reducing aggression and psychosis in Alzheimer's patients with behavioural problems, but are associated with serious adverse effects, such as cerebrovascular events, movement difficulties or cognitive decline, that do not permit their routine use.[141]

Psychosocial intervention

A specifically designed room for sensory integration therapy, also called snoezelen; an emotion-oriented psychosocial intervention for people with dementia

Psychosocial interventions are used as an adjunct to pharmaceutical treatment and can be classified within behaviour-, emotion-, cognition- or stimulation-oriented approaches. Research on efficacy is unavailable and rarely specific to AD, focusing instead on dementia in general.[142]

Behavioural interventions attempt to identify and reduce the antecedents and consequences of problem behaviours. This approach has not shown success in improving overall functioning,[143] but can help to reduce some specific problem behaviours, such as incontinence.[144] There is a lack of high quality data on the effectiveness of these techniques in other behaviour problems such as wandering.[145][146]

Emotion-oriented interventions include reminiscence therapy, validation therapy, supportive psychotherapy, sensory integration, also called snoezelen, and simulated presence therapy. Supportive psychotherapy has received little or no formal scientific study, but some clinicians find it useful in helping mildly impaired patients adjust to their illness.[142] Reminiscence therapy (RT) involves the discussion of past experiences individually or in group, many times with the aid of photographs, household items, music and sound recordings, or other familiar items from the past. Although there are few quality studies on the effectiveness of RT, it may be beneficial for cognition and mood.[147] Simulated presence therapy (SPT) is based on attachment theories and involves playing a recording with voices of the closest relatives of the person with Alzheimer's disease. There is preliminary evidence indicating that SPT may reduce anxiety and challenging behaviours.[148][149] Finally, validation therapy is based on acceptance of the reality and personal truth of another's experience, while sensory integration is based on exercises aimed to stimulate senses. There is little evidence to support the usefulness of these therapies.[150][151]

The aim of cognition-oriented treatments, which include reality orientation and cognitive retraining, is the reduction of cognitive deficits. Reality orientation consists in the presentation of information about time, place or person in order to ease the understanding of the person about its surroundings and his place in them. On the other hand cognitive retraining tries to improve impaired capacities by exercitation of mental abilities. Both have shown some efficacy improving cognitive capacities,[152][153] although in some studies these effects were transient and negative effects, such as frustration, have also been reported.[142]

Stimulation-oriented treatments include art, music and pet therapies, exercise, and any other kind of recreational activities. Stimulation has modest support for improving behaviour, mood, and, to a lesser extent, function. Nevertheless, as important as these effects are, the main support for the use of stimulation therapies is the improvement in the person's daily life routines.[142]

Caregiving

Further information: [[:Caregiving and dementia]]

Since Alzheimer's has no cure and it gradually renders people incapable of tending for their own needs, caregiving essentially is the treatment and must be carefully managed over the course of the disease.

During the early and moderate stages, modifications to the living environment and lifestyle can increase patient safety and reduce caretaker burden.[154][155] Examples of such modifications are the adherence to simplified routines, the placing of safety locks, the labelling of household items to cue the person with the disease or the use of modified daily life objects.[156][157][142] The patient may also become incapable of feeding themselves, so they require food in smaller pieces or pureed.[158] When swallowing difficulties arise, the use of feeding tubes may be required. In such cases, the medical efficacy and ethics of continuing feeding is an important consideration of the caregivers and family members.[159][160] The use of physical restraints is rarely indicated in any stage of the disease, although there are situations when they are necessary to prevent harm to the person with AD or their caregivers.[142]

As the disease progresses, different medical issues can appear, such as oral and dental disease, pressure ulcers, malnutrition, hygiene problems, or respiratory, skin, or eye infections. Careful management can prevent them, while professional treatment is needed when they do arise.[161][48] During the final stages of the disease, treatment is centred on relieving discomfort until death.[162]

Prognosis

The early stages of Alzheimer's disease are difficult to diagnose. A definitive diagnosis is usually made once cognitive impairment compromises daily living activities, although the person may still be living independently. He will progress from mild cognitive problems, such as memory loss through increasing stages of cognitive and non-cognitive disturbances, eliminating any possibility of independent living.[30]

Life expectancy of the population with the disease is reduced.[8][163][164] The mean life expectancy following diagnosis is approximately seven years.[8] Fewer than 3% of patients live more than fourteen years.[9] Disease features significantly associated with reduced survival are an increased severity of cognitive impairment, decreased functional level, history of falls, and disturbances in the neurological examination. Other coincident diseases such as heart problems, diabetes or history of alcohol abuse are also related with shortened survival.[165][163][166] While the earlier the age at onset the higher the total survival years, life expectancy is particularly reduced when compared to the healthy population among those who are younger.[164] Men have a less favourable survival prognosis than women.[9][167]

The disease is the underlying cause of death in 70% of all cases.[8] Pneumonia and dehydration are the most frequent immediate causes of death, while cancer is a less frequent cause of death than in the general population.[8][167]

Epidemiology

AD incidence rates
after 65 years of age[168]
Age Incidence
(new affected)
per thousand
person-years
65–69 2
70–74 6
75–79 9
80–84 23
85–89 40
Older than 90 69

Two main measures are used in epidemiological studies: incidence and prevalence. Incidence is the number of new cases per unit of person-time at risk (usually number of new cases per thousand person-years); while prevalence is the total number of cases of the disease in the population at a given time.

Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10–15 per thousand person-years for all dementias and 5–8 for AD,[169][168] which means that half of new dementia cases each year are AD. Advancing age is a primary risk factor for the disease and incidence rates are not equal for all ages: every five years after the age of 65, the risk of acquiring the disease approximately doubles, increasing from 2 to as much as 69 per thousand person years.[169][168] There are also sex differences in the incidence rates, women having a higher risk of developing AD particularly in the population older than 85.[170][169]

Prevalence of AD in populations is dependent upon different factors including incidence and survival. Since the incidence of AD increases with age, it is particularly important to include the mean age of the population of interest. In the United States, Alzheimer prevalence was estimated to be 1.6% in the year 2000. In the 65–74 age group, approximately 5% of the U.S. population has AD, with the rate increasing to nearly 20% in the 75–84 group and to 50% in the greater than 84 group.[171] Prevalence rates in less developed countries, such as India [172] or Taiwan,[173] are usually lower. In 2005, the World Health Organization estimated that approximately 24.5 million people worldwide have a form of dementia, and that this would increase to 30 million in 2015 and reach 45 million by 2030.[174] Other studies have reached similar conclusions.[175] In 2006, another study estimated that 26.6 million individuals in the world were afflicted by AD, and also predicted that it would multiply by four by the year 2050.[2]

History

Auguste D, first described patient with AD by Alöis Alzheimer in 1901

The ancient Greek and Roman philosophers and physicians associated old-age with increasing dementia.[176] It was not until 1901 that German psychiatrist Alöis Alzheimer identified the first case of what became known as Alzheimer's disease in a fifty-year-old woman he called Auguste D. Alöis Alzheimer followed her until she died in 1906, when he first reported the case publicly.[177] During the next five years, eleven similar cases were reported in the medical literature, some of them already using the term Alzheimer's disease.[176] The disease was first described as a distinctive disease by Emil Kraepelin, who included Alzheimer’s disease, also named presenile dementia by Kraepelin, as a subtype of senile dementia in the eighth edition of his Textbook of Psychiatry, published in 1910.[178]

For most of the twentieth century, the diagnosis of Alzheimer's disease was reserved for individuals between the ages of 45 and 65 who developed symptoms of dementia. The terminology changed after 1977 when a conference on AD concluded that the clinical and pathological manifestations of presenile and senile dementia were almost identical, although the authors also added that this did not rule out the possibility of different aetiologies.[179] This eventually led to the diagnosis of Alzheimer's disease independently of age.[180] The term senile dementia of the Alzheimer type (SDAT) was used for a time to describe the condition in those over 65, with classical Alzheimer's disease being used for those younger. Eventually, the term Alzheimer's disease was formally adopted in medical nomenclature to describe individuals of all ages with a characteristic common symptom pattern, disease course, and neuropathology.[181]

Society and culture

Social costs

Dementia, and specifically Alzheimer's disease, may be among the most costly diseases for society in the developed countries,[17][18] while their cost in developing countries such as Argentina,[182] or Korea,[183] is also high and rising. These costs will probably increase with the ageing of society, becoming an important social problem. AD associated costs include direct medical costs such as nursing home care, direct nonmedical costs such as in-home day care, and indirect costs such as lost patient and caregiver productivity.[18] Numbers vary between studies but dementia costs worldwide have been calculated around $160 billion,[184] while costs of Alzheimer in the United States may be $100 billion each year.[18]

The greatest origin of costs for society is the long-term care by health care professionals and particularly institutionalisation, which corresponds to 2/3 of the total costs for society.[17] The cost of living at home is also very high,[17] specially when informal costs for the family, such as caregiving time and caregiver's lost earnings, are taken into account.[185]

Costs increase with dementia severity and the presence of behavioural disturbances,[186] and are related to the increased caregiving time required for the provision of physical care.[185] Therefore any treatment that slows cognitive decline, delays institutionalisation or reduces caregivers hours will have economic benefits. Economic evaluations of current treatments have shown positive results.[18]

Caregiving burden

Further information: [[:Caregiving and dementia]]

The role of the main caregiver is often taken by the spouse or a close relative.[187] Alzheimer's disease is known for placing a great burden on caregivers which includes social, psychological, physical or economic aspects.[14][15][16] Home care is usually preferred by patients and families.[188] This option also delays or eliminates the need for more professional and costly levels of care.[189][188] Nevertheless two-thirds of nursing home residents have dementias.[142]

Dementia caregivers are subject to high rates of physical and mental disorders.[190] Factors associated with greater psychosocial problems of the primary caregivers include having an affected person at home, the carer being a spouse, demanding behaviours of the cared person such as depression, behavioural disturbances, hallucinations, sleep problems or walking disruptions and social isolation.[191][192] Regarding economic problems, family caregivers often give up time from work to spend 47 hours per week on average with the person with AD, while the costs of caring for them are high. Direct and indirect costs of caring for an Alzheimer's patient average between $18,000 and $77,500 per year in the United States, depending on the study.[193][185]

Cognitive behavioural therapy and the teaching of coping strategies either individually or in group have demonstrated their efficacy in improving caregivers psychological health.[14][194] Caregiving can also have positive benefits such as lessened postloss depression and grief in some cases.[16][195]

Notable cases

Further information: [[:Alzheimer's in the media]]
Charlton Heston and Ronald Reagan at a meeting in the White House. Both of them would later develop Alzheimer's disease.

As Alzheimer's disease is highly prevalent, many notable people have developed it. Well-known examples are former United States President Ronald Reagan and Irish writer Iris Murdoch, both of whom were the subjects of scientific articles examining how their cognitive capacities deteriorated with the disease.[196][197] Other notable cases include the retired footballer Ferenc Puskas,[198] the former British Prime Minister Harold Wilson,[199] the actress Rita Hayworth,[200] the actor Charlton Heston,[201] and the novelist Terry Pratchett.[202]

AD has also been portrayed in films such as: Iris (2001),[203] based on John Bayley's memoir of his wife Iris Murdoch;[204] The Notebook (2004),[205] based on Nicholas Sparks' 1996 novel of the same name;[206] Thanmathra (2005);[207] Memories of Tomorrow (Ashita no Kioku) (2006),[208] based on Hiroshi Ogiwara's novel of the same name;[209] and Away from Her (2006), based on Alice Munro's short story "The Bear Came over the Mountain".[210] Documentaries on Alzheimer's disease include Malcolm and Barbara: A Love Story (1999) and Malcolm and Barbara: Love’s Farewell (2007), both featuring Malcolm Pointon.[211]

Research directions

Main article: Alzheimer's disease clinical research

As of 2008, the safety and efficacy of more than 400 pharmaceutical treatments are being investigated in clinical trials worldwide, and approximately one-fourth of these compounds are in Phase III trials, which is the last step prior to review by regulatory agencies.[212]

One area of clinical research is focused on treating the underlying disease pathology. Reduction of amyloid beta levels is a common target of compounds under investigation. Immunotherapy or vaccination for the amyloid protein is one treatment modality under study. Unlike preventative vaccination, the putative therapy would be used to treat people already diagnosed. It is based upon the concept of training the immune system to recognise, attack, and reverse deposition of amyloid, thereby altering the course of the disease.[213] An example of such a vaccine under investigation was ACC-001,[214][215] although the trials were suspended in 2008.[216] Similar agents are bapineuzumab, an antibody designed as identical to the naturally-induced anti-amyloid antibody,[217] and MPC-7869, a selective amyloid beta-42 lowering agent.[218] Other approaches are neuroprotective agents, such as AL-108,[219] and metal-protein interaction attenuation agents, such as PBT2.[220] A TNFα receptor fusion protein, etanercept has showed encouraging results.[221]

In 2008, two separate clinical trials showed positive results in modifying the course of disease in mild to moderate AD with methylthioninium chloride (trade name rember), a drug that inhibits tau aggregation,[222][223] and dimebon, an antihistamine.[224]

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  102. ^ Vitamins prevent:
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Further reading

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