阿尔茲海默病

阿尔茲海默病（拉丁语：morbus Alzheimer；德语：Alzheimer-Krankheit；英语：Alzheimer's disease），俗称“老年痴懛”，貤有叫伊認知障礙症个，是一種发病进程缓慢、随著辰光推延不断恶化个持续性神经功能障碍。

历史

德国精神病学家爱罗斯·阿尔兹海默来拉1907年顶早报告隻毛病，由此命名。

病因

病因至今不明。比较行个假说有得“β类淀粉样蛋白堆积”、“τ蛋白异常导致神经纤维纠结”咾啥，但是多年来基于箇方面个新药开发几乎全军覆没。Joel T. Dudley团队基于944隻大脑样本分析显示，患者搭健康人个基因表达明显两样，外加搭疱疹病毒感染搭界。^[1]Liang Oscar Qiang则发现，τ蛋白好保持微管动态生长，而不像老早认为个保持微管稳定。^[2]

文献

↑ Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
↑ Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

[1] Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

[2] Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

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