3-Methyl-GABA

3-Methyl-GABA
Names
	IUPAC name 4-Amino-3-methylbutanoic acid
	Other names HMS3266K11; HMS3411G19;
Identifiers
CAS Number	71135-23-4;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:93881;
ChEMBL	ChEMBL275655;
ChemSpider	2778160;
PubChem CID	3539719;
	InChI InChI=1S/C5H11NO2/c1-4(3-6)2-5(7)8/h4H,2-3,6H2,1H3,(H,7,8) Key: CZGLBWZXGIAIBU-UHFFFAOYSA-N;
	SMILES CC(CC(=O)O)CN;
Properties
Chemical formula	C5H11NO2
Molar mass	117.148 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.^[1]

References

^ Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.

[1] Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.

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