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CPA5

From Wikipedia, the free encyclopedia

CPA5
Identifiers
AliasesCPA5, carboxypeptidase A5
External IDsOMIM: 609561; MGI: 1921899; HomoloGene: 62246; GeneCards: CPA5; OMA:CPA5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127441
NM_001127442
NM_080385
NM_001318223

NM_144537

RefSeq (protein)

NP_001120913
NP_001120914
NP_001305152
NP_525124

NP_653120

Location (UCSC)Chr 7: 130.34 – 130.37 MbChr 6: 30.61 – 30.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.[5][6]

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158525Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029788Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi:10.1074/jbc.M112254200. PMID 11836249.
  6. ^ a b "Entrez Gene: CPA5 carboxypeptidase A5".
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Further reading

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